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| 1 | Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease显示文摘Studies have shown that mesenchymal stem cell-derived exosomes can enhance neural plasticity and improve cognitive impairment.The purpose of this study was to investigate the effects of mesenchymal stem cell-derived exosomes on neurogenesis and cognitive capacity in a mouse model of Alzheimer’s disease.Alzheimer’s disease mouse models were established by injection of beta amyloid 1?42 aggregates into dentate gyrus bilaterally.Morris water maze and novel object recognition tests were performed to evaluate mouse cognitive deficits at 14 and 28 days after administration.Afterwards,neurogenesis in the subventricular zone was determined by immunofluorescence using doublecortin and PSA-NCAM antibodies.Results showed that mesenchymal stem cells-derived exosomes stimulated neurogenesis in the subventricular zone and alleviated beta amyloid 1?42-induced cognitive impairment,and these effects are similar to those shown in the mesenchymal stem cells.These findings provide evidence to validate the possibility of developing cell-free therapeutic strategies for Alzheimer’s disease.All procedures and experiments were approved by Institutional Animal Care and Use Committee(CICUAL)(approval No.CICUAL 2016-011)on April 25,2016. | Edwin E. Reza-Zaldivar Mercedes A. Hernández-Sapiéns Yanet K. Gutiérrez-Mercado Sergio Sandoval-ávila Ulises Gomez-Pinedo Ana L. Márquez-Aguirre Estefanía Vázquez-Méndez Eduardo Padilla-Camberos Alejandro A. Canales-Aguirre | 2019 | Neural Regeneration Research2019，14，9： | 19 |
| 2 | A Multiscalar Drought Index Sensitive to Global Warming: The Standardized Precipitation Evapotranspiration Index显示文摘 | Vicente-Serrano Sergio M Beguería Santiago López-Moreno Juan I | 2010 | Journal of Climate2010，，7： | 8 |
| 3 | A Multiscalar Drought Index Sensitive to Global Warming: The Standardized Precipitation Evapotranspiration Index显示文摘 | Vicente-Serrano Sergio M Beguería Santiago López-Moreno Juan I | 2010 | Journal of Climate2010，，7： | 4 |
| 4 | Seasonal population changes in the restriction fragment length polymorphism(RFLP)patterns from PCR-amplified16SrRNA genes of predominant ribotypes in microbial mat samples from the Ebro Delta(Spain)显示文摘 | Sergio R M Mariaramos M A Sebasrian M A | 2003 | Current Microbiology2003，46，： | 1 |
| 5 | A multicentre randomized trial of combined individual and telephone counselling for smoking cessation显示文摘 | Josep M. Ramon Isabel Nerin Araceli Comino Cristina Pinet Francesc Abella José M a Carreras Marta Banque Antoni Baena Sergio Morchon Adriana Jimenez-Muro Adriana Marqueta Assumpcio Vilarasau Raquel Bullon Cristina Masuet-Aumatell | 2013 | Preventive Medicine2013，，： | 1 |
| 6 | Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice显示文摘 | Ronaldo A Ribeiro Mariana L Vale Sara M Thomazzi Adriana B.P Paschoalato Steve Poole Sergio H Ferreira Fernando Q Cunha | 2000 | European Journal of Pharmacology2000，，1： | 1 |
| 7 | A model-based direct power control for three-phase power converters显示文摘 | SERGIO V Juan A S Juan M C | | 0，，04： | 1 |
| 8 | Stator wingding fault diagnosis in three-phase synchronous and asynchronous motors by the extended Park' s vector approach 显示文摘 | Sergio M A Cruz A J Marques Cardoso | 2001 | IEEE Transaction on Industry Applications2001，37，5： | 1 |
| 9 | Visual Space Perception and Visually Directed Action显示文摘 | Jack M Loomis Naofumi Fujita Josi A Da Silva Sergio S Fukusima | 1992 | Journal of Experimental Psychology:Human Perception and Performance (S0096-1523)1992，18，4： | 1 |
| 10 | 临床怀疑深静脉血栓形成病人的压迫超声诊断:前瞻性队列研究显示文摘目的:评价临床上怀疑为深静脉血栓形成但压迫超声显像所见正常病人不给予肝素治疗的安全性。设计:根据一种简化的程序来做压迫超声显像,超声显像的部位限于3处,即腹股沟部的股总静脉、腘静脉及胭静脉远端小腿静脉的分叉部位。初诊时超声显像为正常的病人1周后再重复检查1次。评价结果的标准:对于临床上怀疑为深静脉血栓形成的病人,凡是间隔1周两次超声显像均正常者则不予以肝素治疗,随访6个月,统计在这段时间内静脉血栓栓塞合并症的发生率。参加单位:四所大学附属医院的研究中心。结果:本研究共包括1702名病人,第一次检查发现400名血栓形成者,第二次检查又发现12名,因此用超声诊断方法在该1702名临床上怀疑为深静脉血栓形成的病人中确诊了412例,占24%。全组病人均获得随访,在两次 B 超检查之间,有1例发生了静脉血栓性栓塞的合并症,在6个月随访期间又有8例,所以累计发生率为0.7%(95%可信限为0.3%~1.2%),登门随访及补做检查的次数为平均每例0.8次。结论:对于临床上怀疑为深静脉血栓形成的病人,若连续两次压迫超声检查均为正常者,不给予肝素治疗是安全的。 | Alberto Cogo Anthonie W A Lensing Maria M W Koopman Franco Piovella Sergio Siragusa Philip S Wells Sabina Villalta Harry R Bller Alexander G G Turpie Paolo Prandoni 冷希圣 | 1998 | 英国医学杂志中文版1998，0，1： | 1 |
| 11 | Phenotyping vigour control capacity of new peach rootstocks by xylem vessel analysis 显示文摘 | SERGIO T ALI A THEODORE M D | 2011 | Scientia Horticulturae2011，127，3： | 1 |
| 12 | An architectural role for a nuclear non-coding RNA:NEAT1 RNA is essential for the structure of paraspeckles显示文摘 | Christine M John N Sergio A | 2009 | Cell2009，33，6： | 1 |
| 13 | Performance of Drought Indices for Ecological, Agricultural, and Hydrological Applications显示文摘 | Vicente-Serrano Sergio M Beguería Santiago Lorenzo-Lacruz Jorge Camarero Jesús Julio López-Moreno Juan I Azorin-Molina Cesar Revuelto Jesús Morán-Tejeda Enrique Sanchez-Lorenzo Arturo | 2012 | EN2012，，10： | 1 |
| 14 | Evidence of increasing drought severity caused by temperature rise in southern Europe显示文摘 | Sergio M Vicente-Serrano Juan-I Lopez-Moreno Santiago Beguería Jorge Lorenzo-Lacruz Arturo Sanchez-Lorenzo José M García-Ruiz Cesar Azorin-Molina Enrique Morán-Tejeda Jesús Revuelto Ricardo Trigo Fatima Coelho Francisco Espejo | 2014 | Environmental Research Letters2014，，4： | 1 |
| 15 | Transforming growth factor-β1 gene polymorphisms are associated with disease progression in idiopathic pulmonary fibrosis显示文摘 | ANTONI X AHJANDRA M A SERGIO L | 2003 | Am J Respair Crit Med2003，168，9： | 1 |
| 16 | Wind erosion quantity and quality of an Entic Haplustoll of the semi-arid pampas of Argentina显示文摘 | BUSCHIAZZO Daniel E ZOBECK Ted M ABASCAL Sergio A | 2007 | Journal of Arid Environments2007，，： | 1 |
| 17 | Oxidative stress expression status associated to Helicobacter pylori virulence in gastric diseases显示文摘 | Amanda C A Fernanda M Sergio M | 2007 | Clinical Biochemistry2007，40，： | 1 |
| 18 | Structure and population dynamics of Pinus lagunae M F Passini显示文摘 | Sarad Carmen M Sergio A C | 2000 | Forest Ecology and Management2000，13，： | 1 |
| 19 | A Multiscalar Drought Index Sensitive to Global Warming: The Standardized Precipitation Evapotranspiration Index显示文摘 | Vicente-Serrano Sergio M Beguería Santiago López-Moreno Juan I | 2010 | Journal of Climate2010，，7： | 1 |
| 20 | Use of factorial design for optimizationof microwave-assisted digestion of lubricating oil显示文摘 | LETICIA M COSTA SERGIO L C FERREIRA ANARITA A Nogueira | 2005 | BrazChem Soc2005，16，6： | 1 |
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