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| 1 | Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests显示文摘AIM: To assess whether non invasive blood flow measurement by arterial spin labeling in several brain regions detects minimal hepatic encephalopathy. METHODS: Blood flow(BF) was analyzed by arterial spin labeling(ASL) in different brain areas of 14 controls, 24 cirrhotic patients without and 16 cirrhotic patients with minimal hepatic encephalopathy(MHE). Images were collected using a 3 Tesla MR scanner(Achieva 3T-TX, Philips, Netherlands). Pulsed ASL was performed. Patients showing MHE were detected using the battery Psychometric Hepatic Encephalopathy Score(PHES) consisting of five tests. Different cognitive and motor functions were also assessed: alterations in selective attention were evaluated using the Stroop test. Patients and controls also performed visuo-motor and bimanual coordination tests. Several biochemical parameters were measured: serum pro-inflammatory interleukins(IL-6 and IL-18), 3-nitrotyrosine, cGMP and nitrates+nitrites in plasma, and blood ammonia. Bivariate correlations were evaluated.RESULTS: In patients with MHE, BF was increased in cerebellar hemisphere(P = 0.03) and vermis(P = 0.012) and reduced in occipital lobe(P = 0.017). BF in cerebellar hemisphere was also increased in patients without MHE(P = 0.02). Bimanual coordination was impaired in patients without MHE(P = 0.05) and much more in patients with MHE(P < 0.0001). Visuo-motor coordination was impaired only in patients with MHE(P < 0.0001). Attention was slightly affected in patients without MHE and more strongly in patients with MHE(P< 0.0001). BF in cerebellar hemisphere and vermis correlated with performance in most tests of PHES [(number connection tests A(NCT-A), B(NCT-B)and line tracing test] and in the congruent task of Stroop test. BF in frontal lobe correlated with NCT-A. Performance in bimanual and visuomotor coordination tests correlated only with BF in cerebellar hemisphere. BF in occipital lobe correlates with performance in the PHES battery and with CFF. BF in cerebellar hemisphere correlates with plasma cGMP and nitric oxide(NO) metabolites. BF in vermis cerebellar also correlates with NO metabolites and with 3-nitrotyrosine. IL-18 in plasma correlates with BF in thalamus and occipital lobe.CONCLUSION: Non invasive BF determination in cerebellum using ASL may detect MHE earlier than the PHES. Altered NO-cGMP pathway seems to be associated to altered BF in cerebellum. | Vicente Felipo Amparo Urios Carla Giménez-Garzó Omar Cauli Maria-Jesús Andrés-Costa Olga González Miguel A Serra Javier Sánchez-González Roberto Aliaga Remedios Giner-Durán Vicente Belloch Carmina Montoliu | 2014 | World Journal of Gastroenterology2014，20，33： | 12 |
| 2 | Biometric and ICL-related risk factors associated to sub-optimal vaults in eyes implanted with implantable collamer lenses显示文摘Background:To identify biometric and implantable collamer lens(ICL)-related risk factors associated with suboptimal postoperative vault in eyes implanted with phakic ICL.Methods:This study reports a retrospective case series of the first operated eye in 360 patients implanted with myopic spherical or toric ICL.Preoperatively,white-to-white(WTW),central keratometry(Kc)and central corneal thickness(CCT)were measured using the Pentacam.Anterior-segment optical coherence tomography(AS-OCT,Visante)was applied preoperatively for measuring the horizontal anterior-chamber angle-to-angle distance(ATA),internal anterior chamber depth(ACD),crystalline lens rise(CLR),anterior-chamber angle(ACA)and postoperatively the vault.Eyes were divided into three vault groups:low(LVG:≤250μm),optimal(OVG:>250 and<1000μm)and high(HVG:≥1000μm).Multinomial logistic regression(MLR)was used to find the sub-optimal vault predictors.Results:MLR showed that CLR,ICL size minus the ATA(ICL size-ATA),age,ICL spherical equivalent(ICLSE)and ICL size as contributing factors for sub-optimal vaults(pseudo-R2=0.40).Increased CLR(OR:1.01,CI:1.00-1.01)and less myopic ICLSE(OR:1.22,CI:1.07-1.40)were risk factors for low vaults.Larger ICL size-ATA(OR:41.29,CI:10.57-161.22)and the 13.7mm ICL(OR:7.08,CI:3.16-15.89)were risk factors for high vaults,whereas less myopic ICLSE(OR:0.85,CI:0.76-0.95)and older age(OR:0.92,CI:0.88-0.98)were protective factors.Conclusion:High CLR and low ICLSE were the major risk factors in eyes presenting low vaults.In the opposite direction,ICL size-ATA was the major contributor for high vaults.This relationship was more critical in higher myopic ICLSE,younger eyes and when 13.7mm ICL were used.The findings show that factors influencing the vault have differentiated weight of influence depending on the type of vault(low,optimal or high). | Santiago Cerpa Manito Angel Sánchez Trancón Oscar Torrado Sierra António Manuel Baptista Pedro Miguel Serra | 2021 | Eye and Vision2021，8，1： | 5 |
| 3 | Predictors of morbidity and mortality after the first episode of upper gastrointestinal bleeding in liver cirrhosis显示文摘 | Juan A.del Olmo Andrés Pe?a Miguel A Serra Abdallah H Wassel Adolfo Benages José M Rodrigo | 2000 | Journal of Hepatology2000，，1： | 2 |
| 4 | Noncollision Solutions to Some Singular Minimization Problems with Keplerian-like Potentials 显示文摘 | Serra E Terracini S | 1994 | Nonlinear Analysis Theory Methods and Applications1994，22，1： | 1 |
| 5 | A global movement toward an ecosystem approach to management of marine resources显示文摘 | Sherman K Sissenwine M Christensen V Duda A Hempel G Ibe C Levin S Liuch-Belda D Matishov G McGlade J O'Toole M Switzinger S Serra R Skjoldat H-R Tang Q Thulin J Vandeweerd V Zwanenburg K | | 0，，： | 1 |
| 6 | Os- RMC, a negative regulator of salt stress response in rice, is regu- lated by two AP2/ERF transcription factors显示文摘 | SERRA T S FIGUEIREDO D D CORDEIRO A M | 2013 | Plant Molecular Biology2013，82，45： | 1 |
| 7 | On isoperimetric connectivity in vertex-transitive graphs 显示文摘 | Hamidoune Y O Llada A S Serra O | 2000 | SIAM Journal on Discrete Mathematics2000，13，1： | 1 |
| 8 | Cellular Automata: From a Theoretical Parallel Computational Model to its Application to Complex Systems显示文摘 | Bandini S Mauri G Serra R | 2001 | Parrallel Computing2001，27，： | 1 |
| 9 | Collisionless Periodic Solutions to Some Three-body Problems 显示文摘 | Serra E Terracini S | 1992 | Arch Rational Mech Anal1992，120，4： | 1 |
| 10 | Cellular automata:From a theoretical parallel computational model to its application to complex systems显示文摘 | S Bandini G Mauri R Serra | 2001 | Parallel Computing2001，27，： | 1 |
| 11 | Optically active ionones and derivatives: Preparation and olfactory properties 显示文摘 | Brenna E Fuganti C Serra S | 2002 | Eur J Org Chem2002，5，6： | 1 |
| 12 | Unusual locations of osteoar ticular tuberculosis显示文摘 | Garcia S Combalia A Serra A | 1997 | Arch Orthop Trauma Surg1997，116，32： | 1 |
| 13 | Comparison study of pivot methods for global optimization 显示文摘 | Serra P Stanton AF Kais S | 1997 | The Journal of Chemical Physics1997，106，17： | 1 |
| 14 | Prognostic value of P-glycoproteinin high-grade osteosarcoma显示文摘 | Serra M Picci P Ferrari S | 2007 | J ClinOncol2007，25，30： | 1 |
| 15 | U1- tralow-dissipation micro-oscillator for quantum optomechanics 显示文摘 | SERRA E BORRIELLI A CATALIOTH F S | 2012 | Physical Review A2012，86，05： | 1 |
| 16 | Effectiveness of Type I interferons in the treatment of multidrug resistant os- teosarcoma cells 显示文摘 | Manara MC Serra M Benini S | 2004 | Int J Oncol2004，24，2： | 1 |
| 17 | Gastric biop- sies:the gap between evidence-based medicine and daily practice in the management of gastric Helicobacter pylori infection显示文摘 | E1-Zimaity H Serra S Szentgyorgyi E | 2013 | Can J Gastroenterol2013，27，10： | 1 |
| 18 | Pulsed laser deposition of hydroxylapatite thin films on biomorphic silicon carbide ceramics显示文摘 | J P BORRAJO J SERRA S LISTE | 2005 | Applied Surface Science2005，248，： | 1 |
| 19 | A high-throughput proteomic approach provides distinct signatures for thyroid cancer behavior显示文摘 | Cheng S Serra S Mercado M | 2011 | Clio Cancer Res2011，17，8： | 1 |
| 20 | Copper-zinc superoxide dismutase activity in red blood cells in probable Alzheimer's patients and their firstdegee relatives显示文摘 | SERRA J A FAMULARI A L KOHAN S | 1994 | J Neurol Sci1994，122，2： | 1 |
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