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| 1 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 2 | RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation显示文摘PTEN 肿瘤 suppressor 是在调整 phosphatidylinositol-3-kinase (PI3K ) 有一个中央角色的类脂化合物磷酸酶信号 transduction 串联。不过, PTEN 活动被在房间调整的机制需要进一步的说明。尽管以前的研究证明了 PTEN 的 ubiquitination 能调制它的稳定性和 subcellular 本地化,在 PTEN 功能的最批评的方面的 ubiquitination 的角色,它的磷酸酶活动,充分没被探讨。这里,我们识别 PTEN 的新奇 E3 ubiquitin ligase,沤手指蛋白质(RFP ) ,那能支持 PTEN 的不正常的 polyubiquitinations。这些 ubiquitinations 不导致 PTEN 不稳定性或本地化,但是相当显著地禁止 PTEN 磷酸酶活动因此调制它的能力调整 PI3K 信号 transduction 串联。确实, RFP overexpression 在 AKT 激活上减轻调停 PTEN 的禁止的效果;相反,调停 RNAi 内长的 RFP 击倒提高 PTEN 的能力压制 AKT 激活。而且, PTEN 的调停 RFP 的 ubiquitination 禁止小道表示的 PTEN 依赖的激活并且也压制它的能力导致 apoptosis。我们的调查结果在控制 PTEN 表明调停 RFP 的 ubiquitination 的一个关键角色活动。 | James T Lee Jing Shan Jiayun Zhong Muyang Li Brenda Zhou Amanda Zhou Ramon Parsons Wei Gu | 2013 | Cell Research2013，23，4： | 5 |
| 3 | Chemical and pharmacological evaluation of Hypericum perforation extracts显示文摘KEY WORDS Hypericum perforation; High pressure liquid chromatography; serotonin uptake inhibitors; tree radicals; antioxidants; hyperforin; hypericin; quercetin; rutinABSTRACTAIM: To determine the concentrations of chemical characteristic to extracts of leaves and flowers of Hypericum perforatnm (St John’s wort) in a number of selected samples and, following chemical characterization, to investigate the effects of these extracts on several pharmacological properties including effects of the extracts on inhibition of 5-hydroxytryptamine (5-HT) uptake and on an-tioxidant properties. METHODS: The samples were analyzed for the presence of characteristic chemicals by high performance liquid chromatography (HPLC) directly coupled to ultraviolet wavelength absorbance and positive or negative mode electrospray mass spectrometric detection. The effects of extracts on 5-HT uptake were determined by quantifying 3H-5-HT incorporation into rat hip-pocampal prisms. Estimates of effects of extracts on free radical | B Duff SLOLEY Liana J URICHUK LING Lei GU Lie-Dong Ronald T COUTTS Peter K T PANG Jacqueline J SHAN | 2000 | Acta Pharmacologica Sinica2000，21，12： | 2 |
| 4 | Hsp10 and Hsp60 suppress ubiquitination of insulin-like growth factor-1 receptor and augment insulin-like growth factor-1 receptor signaling in cardiac muscle:implications on decreased myocardial protection in diabetic cardiomyopathy显示文摘 | Shan Y X Yang T L Mestril R | 2003 | J Biol Chem2003，278，45： | 1 |
| 5 | Enhancement of doxorubicin and vinblasrine sensitivity in anthracycline resistant p388 cells 显示文摘 | Ramu A Shan T Glanbiger D | 1983 | Cancer Treat Rep1983，67，： | 1 |
| 6 | Molecular detection andsequence analysis of feline Torque teno virus(TTV)in China显示文摘 | ZHU C X SHAN T L CUI L | 2011 | Virus Res2011，156，12： | 1 |
| 7 | Nutritional status deteriorates as the severity of diabetic foot ulcers increases and independently associates with prognosis 显示文摘 | Shan Z Zheng T Fang P | 2013 | Exp Ther Med2013，5，1： | 1 |
| 8 | HSP10 and HSP60 modulate Bcl- 2 family and mitochondria apoptisis signaling induced by doxorubicin in cardiac muscle cells 显示文摘 | SHAN Y X LIU T J SU H F | 2003 | J Mol Cell Cardiol2003，35，9： | 1 |
| 9 | Evaluation of plant availability of rare earth elements in soils by chemical fractionation and multiple regression analysis 显示文摘 | Li F L Shan X Q Zhang T H | 1998 | Environmental Pollution1998，102，： | 1 |
| 10 | Slewing and vibration con-trol of a single-link flexible manipulator by positive posi- tion feedback (PPF) 显示文摘 | SHAN J LIU H T SUN D | 2005 | Mechatronics2005，15，4： | 1 |
| 11 | Insulin deficiency down regulated heat shock protein 60 and IGF 1 receptor signaling in diabetic myocardium 显示文摘 | Chen H S Shan Y X Yang T L | 2005 | Diabetes2005，54，1： | 1 |
| 12 | Chitin-based tubes for tissue engineering in the nervous system显示文摘 | Freier T Montenegro R Shan Koh H | 2005 | Biomaterials2005，26，22： | 1 |
| 13 | 3D Modelling of Transport Phenomena and the Injection of the Solution Droplets in the Solution Precursor Plasma Spraying 显示文摘 | SHAN Yanguang Coyle T Mostaghimi J | 2007 | Journal of Thermal Spray Technology2007，16，56： | 1 |
| 14 | Real-time hand tracking using a mean shift embedded particle filter显示文摘 | Shan C F Tan T N Wei Y C | 2007 | Pattern Recognition2007，40，7： | 1 |
| 15 | The first detectionof human parechovirus infections in China显示文摘 | Shan T L Guo W Cui L | 2009 | Jour-nal of Clinical Virology2009，45，4： | 1 |
| 16 | Adaptive beamforming for coherent signals and interference显示文摘 | SHAN T J KALLATH T | 1985 | IEEE Tans on Assp1985，33，6： | 1 |
| 17 | Chinese medicinal herb,acanthopanax gracilistylus,extract induces cell cycle arrest of human cells in vitro显示文摘 | Shan BE Zeki K Sugiura T | 2000 | Jpn J Cancer Res2000，91，： | 1 |
| 18 | On spatial smoothing for di-rection-of-arrival estimation of coherent signals 显示文摘 | SHAN Tie-jun WAX M KAILATH T | 1985 | IEEE Trans on Acoustics Speech and Signal Processing1985，33，4： | 1 |
| 19 | A conjugate augmented approach to direction-of-arrival estimation显示文摘 | SHAN Zhilong YUM T S P | 2005 | IEEE Transactions on Signal Processing2005，53，11： | 1 |
| 20 | Numerical simulation of droplet breakup and collision in the solution precursor plasma spraying 显示文摘 | Shan Y Coyle T W Mostaqhimi J | 2007 | Journal of Thermal Spray Technology2007，16，5： | 1 |
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