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| 1 | The dependences of osteocyte network on bone compartment, age, and disease显示文摘Osteocytes, the most abundant bone cells, form an interconnected network in the lacunar-canalicular pore system(LCS) buried within the mineralized matrix, which allows osteocytes to obtain nutrients from the blood supply, sense external mechanical signals, and communicate among themselves and with other cells on bone surfaces. In this study, we examined key features of the LCS network including the topological parameter and the detailed structure of individual connections and their variations in cortical and cancellous compartments, at different ages, and in two disease conditions with altered mechanosensing(perlecan deficiency and diabetes).LCS network showed both topological stability, in terms of conservation of connectivity among osteocyte lacunae(similar to the ‘‘nodes' ' in a computer network), and considerable variability the pericellular annular fluid gap surrounding lacunae and canaliculi(similar to the ‘‘bandwidth'' of individual links in a computer network). Age, in the range of our study(15–32 weeks), affected only the pericellular fluid annulus in cortical bone but not in cancellous bone. Diabetes impacted the spacing of the lacunae, while the perlecan deficiency had a profound influence on the pericellular fluid annulus. The LCS network features play important roles in osteocyte signaling and regulation of bone growth and adaptation. | Xiaohan Lai Christopher Price Shannon Modla William R Thompson Jeffrey Caplan Catherine B Kirn-Safran Liyun Wang | 2015 | Bone Research2015，3，2： | 6 |
| 2 | Parietal lobe contributions to episodic memory retrieval显示文摘 | Wagner A D Shannon B J Kahn I | 2005 | Trends Cogn Sci2005，9，： | 1 |
| 3 | Novel use of waste keratin and cotton linter fibers for prototype tissue papers and their evaluation显示文摘 | SHI B SHANNON T G PELKY E | 2010 | Bio- Resources2010，5，3： | 1 |
| 4 | Effects of volume loading and pressor agents in idiopathic orthostatie tachyeardia 显示文摘 | Jacob G Shannon JR Black B | 1997 | Cir- culation1997，96，2： | 1 |
| 5 | In the series analytic: Biosynthesis and molecular regulation of amino acids in plants 显示文摘 | Singh B K Flores H E Shannon J C | 1992 | American Society of Plant Physiologists : Rockville MD1992，，： | 1 |
| 6 | Active Commuting in a University Setting: Assessing Commuting Habits and Potential for Modal Change显示文摘 | Shannon T Giles-Corti B Pikora T Bulsara M Shilton T Bull F | 2006 | Transport Policy2006，13，3： | 1 |
| 7 | Hyperactive Ras as a therapeutic target in neurofibromatosis type 1 显示文摘 | Weiss B Bollag G Shannon K | 1999 | Am J Med Genet1999，89，1： | 1 |
| 8 | Suture-button syndesmosis fixation:accelerated rehabilitation and improved outcomes显示文摘 | Thornes B Shannon F Guiney AM | 2005 | Clin Orthop Relat Res2005，，431： | 1 |
| 9 | Suture-button syndes- mosis fixation: accelerated rehabilitation and improved outco- mes显示文摘 | Thomes B Shannon F Guiney AM et ol | 2005 | Clin Orthop2005，，431： | 1 |
| 10 | Suture-button syndesmosis fixation:accelerated rehabilitation and improved outcomes 显示文摘 | Thornes B Shannon F Guiney AM | 2005 | Clin Orthop Relat Res2005，431，： | 1 |
| 11 | The GAPS in practice显示文摘 | Anne G Shannon B Margaret Y | 2003 | Arch Pediatr Adolesc Med2003，157，5： | 1 |
| 12 | Effects of volume loading and pressor agents in idiopathic orthostatic tachycardia显示文摘 | Jacob G Shannon JR Black B | | 0，，02： | 1 |
| 13 | Hyperactive Ras as a therapeutic target in neurofibromatosis type 1 显示文摘 | Weiss B Bollag G Shannon K | 1999 | Am J Med Genet1999，89，1： | 1 |
| 14 | Indentification of mutator insertional mutants of starch branching enzyme 2a in corn显示文摘 | Yuan Yao Klucinec J D Shannon J C Thompson D B Guilitinan M J | 2001 | plant physiol2001，125，： | 1 |
| 15 | Comparison and Analysis of Selected English Interpretations of the Tao Te Ching显示文摘 | Damian J B Shannon M F | 2000 | Asian Philosophy2000，，2： | 1 |
| 16 | Giant Aneurysms of Coronary Arteries and Saphenous Vein Grafts: Angiographic Findings and Histopathological Correlates显示文摘 | Topaz O Molly S R Shannon M B etal | 2005 | Cardiovascular Pathology2005，14，6： | 1 |
| 17 | Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients withmetastatic renal cell carcinoma 显示文摘 | RINI B I STEIN M SHANNON P | 2011 | Cancer2011，117，4： | 1 |
| 18 | 显示文摘 | Gibbons W Shannon P Sun S T Swetlin B | 1991 | Nature1991，351，： | 1 |
| 19 | Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol - and obesity - induced fatty liver diseases 显示文摘 | Mantena Sudheer K King Adrienne L Andringa Kelly K Ec- cleston Heather B Bailey Shannon M | 2008 | Free radical biology & medi- cine2008，44，7： | 1 |
| 20 | Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication显示文摘 | Renate K?nig Yingyao Zhou Daniel Elleder Tracy L. Diamond Ghislain M.C. Bonamy Jeffrey T. Irelan Chih-yuan Chiang Buu P. Tu Paul D. De Jesus Caroline E. Lilley Shannon Seidel Amanda M. Opaluch Jeremy S. Caldwell Matthew D. Weitzman Kelli L. Kuhen Sourav B | 2008 | Cell2008，，1： | 1 |
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