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| 1 | Involvement of cholangiocyte proliferation in biliary fibrosis显示文摘Cholangiocytes are the epithelial cells that line the biliary tree.In the adult liver,they are a mitotically dormant cell population,unless ductular reaction is triggered by injury.The ability of cholangiocytes to proliferate is important in many different human pathological liver conditions that target this cell type,which are termed cholangiopathies(i.e.primary biliary cirrhosis,primary sclerosing cholangitis and biliary atresia).In our article,we provide background information on the morphological and functional heterogeneity of cholangiocytes,summarize what is currently known about their proliferative processes,and briefly describe the diseases that target these cells.In addition,we address recent findings that suggest cholangiocyte involvement in epithelial-to-mesenchymal transformation and liver fibrosis,and propose directions for future studies. | Sally Priester Candace Wise Shannon S Glaser | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，2： | 10 |
| 2 | Mechanisms of biliary carcinogenesis and growth显示文摘Cholangiocarcinoma is a rare cancer originating from the neoplastic transformation of the epithelial cells (i.e. cholangiocytes) that line the biliary tract. The prognosis for patients with cholangiocarcinoma is grim due to lack of viable treatment options. The increase in world-wide incidence and mortality from cholangiocarcinoma highlights the importance of understanding the intracellular mechanisms that trigger the neoplastic transformation of cholangiocytes and the growth of biliary cancers. The purpose of the following review is to address what has been learned over the past decade concerning the molecular basis of cholangiocarcinogenesis. The material presented is divided into two sections:(1) mechanisms regulating neoplastic transformation of cholangiocytes; and (2) factors regulating cholangiocarcinoma growth. An understanding of the growth regulatory mechanisms of cholangiocarcinoma will lead to the identification of therapeutic targets for this devastating cancer. | Candace Wise Metaneeya Pilanthananond Benjamin F Perry Gianfranco Alpini Michael McNeal Shannon S Glaser | 2008 | World Journal of Gastroenterology2008，14，19： | 5 |
| 3 | Acute liver failure due to natural killer-like T-cell leukemia/ lymphoma: A case report and review of the Literature显示文摘尖锐的肝失败(ALF ) 是为肝移植要求立即的评估的一种医药紧急情况。我们描述与腹水,黄疸,和脑病介绍了并且被发现由于象 T 房间白血病 / 淋巴瘤一样的生来的杀手(NK ) 有 ALF 的一个病人的一个不平常的盒子。关键免疫显型是 CD2+ , CD3+ , CD7+ , CD56+ 。这诊断,在外部血和腹水基于调查结果,与肝活体检视被证实,并且是到肝移植的禁止徵候。hematologic 恶意是暴发性的肝的失败的一个不平常的原因的文学表演的评论,和那个象 NK 一样 T 房间白血病 / 淋巴瘤是一最近相对表示特性地认出了是的实体 CD3+ 和 CD56+ 。这个盒子证明那肝活体检视在与淋巴瘤 / 白血病能引起尖锐的肝失败的象 NK 一样 T 房间诊断肝的尖锐的肝失败,和那渗入的不平常的原因是必要的。 | Evan S Dellon Shannon R Morris Wozhan Tang Cherie H Dunphy Mark W Russo | 2006 | World Journal of Gastroenterology2006，12，25： | 5 |
| 4 | Effect of pulse rate on collagen deposition in the tissue-engineered blood vessel显示文摘 | Amy S Shannon M Marsha M | 2004 | Tissue Eng2004，9，： | 1 |
| 5 | Statins andprostate cancer risk:a case-control study显示文摘 | Shannon J Tewoderos S Garzotto M | 2005 | Am J Epidemiol2005，162，4： | 1 |
| 6 | Palladium- catalyzed aerobic dehydrogen-ation of substituted cyclo- hexanones to phenols 显示文摘 | Yusuke Izawa Doris Pun Shannon S Stahl | 2011 | Science2011，333，8： | 1 |
| 7 | Folds and striae in laser in situkeratomileusis flaps显示文摘 | Carpel EF Carlson KH Shannon S | | 0，，06： | 1 |
| 8 | Rearing condition and plasma cortisol in rhesus monkey infants 显示文摘 | SHANNON C CHAMPOUX M SUOMI S J | 1998 | American Journal of Primatology1998，46，： | 1 |
| 9 | Indentification of mutator insertional mutants of starch branching enzyme 2a in corn显示文摘 | Yuan Yao Klucinec J D Shannon J C Thompson D B Guilitinan M J | 2001 | plant physiol2001，125，： | 1 |
| 10 | A simple method for evaluation of sprout characters in soybean 显示文摘 | Lee J D Shannon J G Jeong Y S | 2007 | guphytica2007，153，12： | 1 |
| 11 | Giant Aneurysms of Coronary Arteries and Saphenous Vein Grafts: Angiographic Findings and Histopathological Correlates显示文摘 | Topaz O Molly S R Shannon M B etal | 2005 | Cardiovascular Pathology2005，14，6： | 1 |
| 12 | Negative pressure therapy is effective to manage a variety of wounds in infants and children显示文摘 | Shannon S Bindi J Kathy M | 2007 | Wound Repair Rege2007，15，3： | 1 |
| 13 | 显示文摘 | Gibbons W Shannon P Sun S T Swetlin B | 1991 | Nature1991，351，： | 1 |
| 14 | Fathers and mothers at play with their 2 - and 3 - year- olds: contributions to language and cognitive development 显示文摘 | TAMIS- LEMONDA C S SHANNON J D CABRERA N J | 2004 | Child Dev2004，75，6： | 1 |
| 15 | Readiness for organizational change: A longitudinal study of work- place, psychological and behavioural correlates 显示文摘 | CUNNINGHAM C E WOODWARD C A SHANNON H S | 2002 | Journal of Oc- cupational and Organizational Psychology2002，75，4： | 1 |
| 16 | Malignant and benign bone tumors显示文摘 | SHANNON L MILLER M S HOFFER M D | 2001 | Radiol Clin North Am2001，39，4： | 1 |
| 17 | Detection of five legume vi-ruses in one sensitive multiplex polymerase chain reaction test显示文摘 | Bariana H S Shannon A L Chu PW G | 1994 | Phytopathology1994，84，10： | 1 |
| 18 | The type M histone deacetylaseSirtl is essential for maintenance of T cell tolerance in mice显示文摘 | Zhang J Lee SM Shannon S | 2009 | JClin Invest2009，119，： | 1 |
| 19 | 显示文摘 | Bryumor W Robert S Shannon B | 2001 | Am Lab2001，33，9： | 1 |
| 20 | Airway remodeling-associatedmediators in moderate to severe asthma: effect of steroids on TGF-beta,IL-11, IL-17, and type I and type III collagen expression 显示文摘 | Chakir J Shannon J Molet S | 2003 | J AllergyClin Immunol2003，111，6： | 1 |
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