|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Autologous CD34^+ and CD133^+ stem cells transplantation in patients with end stage liver disease显示文摘AIM:To assess the utility of an autologous CD34 + and CD133 + stem cells infusion as a possible therapeutic modality in patients with end-stage liver diseases.METHODS:One hundred and forty patients with endstage liver diseases were randomized into two groups.Group 1,comprising 90 patients,received granulocyte colony stimulating factor for five days followed by autologous CD34 + and CD133 + stem cell infusion in the portal vein.Group 2,comprising 50 patients,received regular liver treatment only and served as a control group.RESULTS:Near normalization of liver enzymes and improvement in synthetic function were observed in 54.5% of the group 1 patients;13.6% of the patients showed stable states in the infused group.None of the patients in the control group showed improvement.No adverse effects were noted.CONCLUSION:Our data showed that a CD34 + and CD133 + stem cells infusion can be used as supportive treatment for end-stage liver disease with satisfactory tolerability. | Hosny Salama Abdel-Rahman N Zekri Abeer A Bahnassy Eman Medhat Hanan A Halim Ola S Ahmed Ghada Mohamed Sheren A Al Alim Ghada M Sherif | 2010 | World Journal of Gastroenterology2010，16，42： | 16 |
| 2 | Ghrelin attenuates gastrointestinal epithelial damage induced by doxorubicin显示文摘AIM:To examine the influence of ghrelin on the regenerative potential of gastrointestinal(GI)epithelium.METHODS:Damage to GI epithelium was induced in mice by two intravenous injections of doxorubicin(10 and 6 mg/kg).Some of the doxorubicin-treated mice received a continuous subcutaneous infusion of ghrelin(1.25μg/h)for 10 d via implanted mini-osmotic pumps.To label dividing stem cells in the S-phase of the cell cycle,all mice received a single intraperitoneal injection of 5'-bromo-2'-deoxyuridine(BrdU)one hour before sacrifice.The stomach along with the duodenum were then removed and processed for histological examination and immunohistochemistry using anti-BrdU antibody.RESULTS:The results showed dramatic damage to the GI epithelium 3 d after administration of chemotherapy which began to recover by day 10.In ghrelintreated mice,attenuation of GI mucosal damage was evident in the tissues examined postchemotherapy.Immunohistochemical analysis showed an increase in the number of BrdUlabeled cells and an alteration in their distribution along the epithelial lining in response to damage by doxorubicin.In mice treated with both doxorubicin and ghrelin,the number of BrdUlabeled cells was reduced when compared with mice treated with doxorubicin alone.CONCLUSION:The present study suggests that ghrelin enhances the regenerative potential of the GI epithelium in doxorubicintreated mice,at least in part,by modulating cell proliferation. | Mohamed A Fahim Hazem Kataya Rkia El-Kharrag Dena AM Amer Basel al-Ramadi Sherif M Karam | 2011 | World Journal of Gastroenterology2011，17，33： | 3 |
| 3 | Profiling cellular bioenergetics, glutathione levels, and caspase activities in stomach biopsies of patients with upper gastrointestinal symptoms显示文摘AIM: To measure biochemical parameters in stomach biopsies and test their suitability as diagnostic biomarkers for gastritis and precancerous lesions.METHODS: Biopsies were obtained from the stomachs of two groups of patients(n = 40) undergoing fiberoptic endoscopy due to upper gastrointestinal symptoms. In the first group(n = 17), only the corpus region was examined. Biopsies were processed for microscopic examination and measurement of mitochondrial O2 consumption(cellular respiration), cellular adenosine triphosphate(ATP), glutathione(GSH), and caspase activity. In the second group of patients(n = 23), both corpus and antral regions were studied. Some biopsies were processed for microscopic examination, while the others were used for measurements of cellular respiration and GSH level.RESULTS: Microscopic examinations of gastric corpus biopsies from 17 patients revealed normal mucosae in 8 patients, superficial gastritis in 7 patients, and chronic atrophic gastritis in 1 patient. In patients with normal histology, the rate(mean ± SD) of cellular respiration was 0.17 ± 0.02 μmol/L O2 min-1 mg-1, ATP content was 487 ± 493 pmol/mg, and GSH was 469 ± 98 pmol/mg. Caspase activity was detected in 3 out of 8 specimens. The values of ATP and caspase activity were highly variable. The presence of superficial gastritis had insignificant effects on the measured biomarkers. In the patient with atrophic gastritis, cellular respiration was high andATP was relatively low, suggesting uncoupling oxidative phosphorylation. In the second cohort of patients, the examined biopsies showed either normal or superficial gastritis. The rate of cellular respiration(O2. μmol/L min-1 mg-1) was slightly higher in the corpus than the antrum(0.18 ± 0.05 vs 0.15 ± 0.04, P = 0.019). The value of GSH was about the same in both tissues(310 ± 135 vs 322 ± 155, P = 0.692).CONCLUSION: The corpus mucosa was metabolically more active than the antrum tissue. The data in this study will help in understanding the pathophysiology of gastric mucosa. | Ali S Alfazari Bayan Al-Dabbagh Wafa Al-Dhaheri Mazen S Taha Ahmad A Chebli Eva M Fontagnier Zaher Koutoubi Jose Kochiyi Sherif M Karam Abdul-Kader Souid | 2015 | World Journal of Gastroenterology2015，21，2： | 2 |
| 4 | Visual and refractive outcomes of posterior chamber phakic IOL in stable keratoconus显示文摘We evaluated the visual and refractive outcomes after phakic visian toric implantable collamer lens(ICL) insertion in stable keratoconus(KC). This retrospective study investigated toric ICL implantation in 14 eyes of 8 patients with stable KC. After 6 mo, the mean uncorrected distance visual acuity improved significantly from 0.77 to 0.15 logMAR. The mean best corrected distance visual acuity(BCDVA) improved from 0.18±0.1 to 0.15±0.1 logMAR. Fifty percent of eyes maintained their preoperative BCDVA; 42.8% gained one line. There was no statistical difference in high order or coma aberration. The mean refractive manifest spherical equivalent(MSE), mean refractive manifest spherical error, mean manifest astigmatism decreased significantly postoperatively. At 6 mo postoperatively, our achieved mean spherical equivalent was approximately 74%. No intraoperative or postoperative complications occurred. Toric ICL implantation was effective, predictable and safe to correct refractive error and improve visual acuity in patients with stable KC. | Sherif H Emerah Moataz M Sabry Hisham A Saad Waleed A Ghobashy | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 2 |
| 5 | Review of application of mass spectrometry for analyses of anterior eye proteome显示文摘Proteins have important functional roles in the body, which can be altered in disease states. The eye is a complex organ rich in proteins; in particular, the anterior eye is very sophisticated in function and is most commonly involved in ophthalmic diseases. Proteomics, the large scale study of proteins, has greatly impacted our knowledge and understanding of gene function in the post-genomic period. The most significant breakthrough in proteomics has been mass spectrometric identification of proteins, which extends analysis far beyond the mere display of proteins that classical techniques provide. Mass spectrometry functions as a 'mass analyzer' which simplifies the identification and quantification of proteins extracted from biological tissue. Mass spectrometric analysis of the anterior eye proteome provides a differential display for protein comparison of normal and diseased tissue. In this article wepresent the key proteomic findings in the recent literature related to the cornea, aqueous humor, trabecular meshwork, iris, ciliary body and lens. Through this we identified unique proteins specific to diseases related to the anterior eye. | Sherif Elsobky Ashley M Crane Michael Margolis Teresia A Carreon Sanjoy K Bhattacharya | 2014 | World Journal of Biological Chemistry2014，5，2： | 2 |
| 6 | Experimental and theoretical performance of a demonstration solar chimney model -part Ⅰ : mathematical model development 显示文摘 | Pasurnarthi N Sherif S A | 1998 | International Journal of Energy Research1998，22，： | 1 |
| 7 | Earth pressures against rigid retaining walls显示文摘 | SHERIF M A ISHIBASHI I LEE C D | 1982 | Journal of the Geotechnical Engineering Division ASCE1982，108，5： | 1 |
| 8 | Some characteristics of multiple helium fragments produced in heavy ion collisions at Dubna energy显示文摘 | EL-NADI M SHERIF M M ABDEL-SALAM A | 1993 | Intern J Mod Phys1993，2，： | 1 |
| 9 | Interface properties due to microslip from vibration measurement显示文摘 | Sherif H A Omar T M A | 2001 | Journal of Tribology2001，123，1： | 1 |
| 10 | Monolithic nanostructured silicate family templated by lyotropic liquid-crystalline nonionic surfactant mesophases显示文摘 | Sherif A E Hanaoka T | 2003 | Adv Mater2003，15，： | 1 |
| 11 | Experimental and theoretical performance of a demonstration solar chimney model-part Ⅱ : experimental and theoretical results and economic analysis 显示文摘 | Pasumarthi N Sherif S A | 1998 | International Journal of Energy Research1998，22，： | 1 |
| 12 | Optimization by pattern search 显示文摘 | Sherif Y S Boice B A | 1994 | European Journal of Operational Research1994，78，3： | 1 |
| 13 | Theroeconomic Analysis of Absorption Systems for Cooling显示文摘 | SHUN-FU LEE S A SHERIF | 2000 | ASHRAE Transactions2000，107，1： | 1 |
| 14 | Hyperinsulinism and sex hormones in young adult African Americans显示文摘 | Falkner B Sherif K Summer A | 1999 | Metabolism1999，48，1： | 1 |
| 15 | Ruptured carotid artery aneurysms of the ophthalmic(C6) segment:clinical and angiographic long term follow- up of a multidisciplinary management strategy显示文摘 | Sherif C Gruber A Dorfer C | 2009 | J Neurol Neurosurg Psychiatry2009，80，： | 1 |
| 16 | Radical cystectomy with orthotopic neobladder for invasive bladder cancer: a critical anal- ysis of long-term oncological, functional, and quality of life re- sults显示文摘 | STENZL A SHERIF H KUCZYK M | 2010 | Int Braz J Urol2010，36，5： | 1 |
| 17 | Pathologic downstaging is a surrogate marker for efficacy and increased survival following neoadjuvant chemotherapy and radical cystectomy for muscle-invasive urothelial bladder cancer显示文摘 | Rosenblatt R Sherif A Rintala E | 2012 | Eur Urol2012，61，6： | 1 |
| 18 | Measurements of the flow and turbulence characteristics of round jets in crossflow 显示文摘 | SHERIF S A PLETCHER R H | 1989 | Journal of Fluids Engineering Transactions of the ASME1989，111，2： | 1 |
| 19 | Dynamic earth pressures on walls rotating about the top显示文摘 | SHERIF M A FANG Y S | 1984 | Soils and Foundations1984，24，4： | 1 |
| 20 | Dynamic earth pressures on walls rotating about the top 显示文摘 | SHERIF M A FANG Y S | 1984 | Soils and Foundations1984，24，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员