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| 1 | Effect of sinter layer porosity distribution on flow and temperature fields in a sinter cooler显示文摘When sinters are filled into the sinter cooler from the sintering machine, it is commonly seen that, due to segregation effects, sinters of larger size usually accumulate closer to the inner wall of the sinter cooler, whereas those of smaller size are to the outer wall. This nonuniform distribution of sinters has led to uneven cooling effect throughout the cooler. This causes the sinters leaving the cooler at a large temperature difference. This undesired temperature difference leads to the deformation and even the destruction of the conveyors. The computational fluid dynamics (CFD) technique was used in the present work to investigate the heat and fluid flow phenomena within the sinter cooler corresponding to the different distribution of sinter layer porosity, which was highly dependent on the arrangement and orientation of sinters within the sinter cooler. It is confirmed that a high mass flow rate within the sinter layer causes a low temperature region and vice versa. The flow fields for vertically reducing porosity distribution and random distribution are almost identical indicating the relative insignificance of convective heat transfer mechanism. | Jik-chang Leong Kai-wun Jin Jia-shyan Shiau Tzer-ming Jeng Chang-hsien Tai | 2009 | International Journal of Minerals,Metallurgy and Materials2009，16，3： | 27 |
| 2 | Downregulation of signal transducer and activator of transcription 3 by sorafenib:A novel mechanism for hepatocellular carcinoma therapy显示文摘Hepatocellular carcinoma is one of the most common cancers worldwide,and a leading cause of cancer-related death.Owing to unsatisfactory clinical outcomes under the current standard of care,there is a need to search for and identify novel and potent therapeutic targets to improve patient outcomes.Sorafenib is the first and only approved targeted therapy for the treatment of hepatocellular carcinoma.Besides functioning as a multiple tyrosine kinase,sorafenib also acts via a kinase-independent mechanism to target signal transducer and activator of transcription 3(STAT3) signaling in hepatocellular carcinoma cells.STAT3 is a key regulator of inflammation,cell survival,and tumorigenesis of liver cells,and the high percentage of hepatocellular carcinoma cells with constitutively active STAT3 justifies targeting it for the development of novel therapeutics.Sorafenib inactivates STAT3 and STAT3-related signaling by inducing a conformational change in and releasing the autoinhibition of Src homology region 2 domaincontaining phosphatase-1.This phosphatase negatively regulates STAT3 activity,which leads to the subsequent apoptosis of cancer cells.The novel anti-cancer property of sorafenib will be discussed in this review,not only adding information regarding its mechanism of action but also providing an innovative approach for the development of cancer therapeutics in the future. | Man-Hsin Hung Wei-Tien Tai Chung-Wai Shiau Kuen-Feng Chen | 2014 | World Journal of Gastroenterology2014，20，41： | 9 |
| 3 | Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma显示文摘 | Wei-Tien Tai Ann-Lii Cheng Chung-Wai Shiau Hsiang-Po Huang Jui-Wen Huang Pei-Jer Chen Kuen-Feng Chen | 2011 | Journal of Hepatology2011，，5： | 4 |
| 4 | A Unified Framework of the Cloud Computing Service Model显示文摘After a comprehensive literature review and analysis, a unified cloud computing framework is proposed, which comprises MapReduce, a vertual machine, Hadoop distributed file system (HDFS), Hbase, Hadoop, and virtualization. This study also compares Microsoft, Trend Micro, and the proposed unified cloud computing architecture to show that the proposed unified framework of the cloud computing service model is comprehensive and appropriate for the current complexities of businesses. The findings of this study can contribute to the knowledge for academics and practitioners to understand, assess, and analyze a cloud computing service application. | Wen-Lung Shiau Chao-Ming Hsiao | 2013 | Journal of Electronic Science and Technology2013，11，2： | 2 |
| 5 | Fitting Drought Duration and Severity with Two-Dimensional Copulas显示文摘 | J. T. Shiau | 2006 | Water Resources Management2006，，5： | 2 |
| 6 | Effect of vibrational stirring on the quality of Bridgman-grown CdTe 显示文摘 | LU Y C SHIAU J J FIEGELSON R S | 1990 | J Cryst Growth1990，102，： | 2 |
| 7 | Direct kinematic analysis of a 3-PRS parallel mechanism显示文摘 | Meng-Shiun Tsai Ting-Nung Shiau Yi-Jeng Tsai Tsann-Huei Chang | 2002 | Mechanism and Machine Theory2002，，1： | 2 |
| 8 | Aorta and iliac arteries: single versus multiple detector-row helical CT angiography 显示文摘 | Rubin GD Shiau MC Leung AN | 2000 | Radiology2000，215，5： | 1 |
| 9 | Endostatin gene therapy delivered by Salmonella choleraesuis in murine tumor models 显示文摘 | Lee CH Wu CL Shiau AL | 2004 | J Gene Med2004，6，12： | 1 |
| 10 | Assessment of hydrological droughts for the yellow river, China, using copulas显示文摘 | J T Shiau Song Feng Saralees Nadarajah | 2007 | Hydrological Processes2007，21，： | 1 |
| 11 | Endostatin gene therapy delivered by Salmonella Choleraesuis in murine tomor models显示文摘 | Che-Hsin Lee Chao-Liang Wu Ai-li Shiau | 2004 | Journal of Gene Medicine2004，6，12： | 1 |
| 12 | Differentiation of radiographically indeterminate solitary pulmonary nodules with fluoro-2-deoxyglucose positron emission tomography显示文摘 | Hung GU Shiau YC Tsai SC | 2001 | Jpn J Clin Oncol2001，31，2： | 1 |
| 13 | Effect of a sonographically diffusely enlarged uterus without distinct uterine masses on the outcome of in vitro fertilization-embryo transfer显示文摘 | Chiang CH Chang MY Shiau CS | 1999 | J Assist Reprod Genet1999，16，8： | 1 |
| 14 | Assessment of hydrological droughts for the Yellow River, China, using copulas 显示文摘 | Shiau JT Feng S Nadarajah S | 2007 | Hydrological Proces- ses2007，21，16： | 1 |
| 15 | Endogenous hy-drogen sulfide contributes to the cardioprotection by metabolic inhibition preconditioning in the rat ventricular myocytes显示文摘 | PAN T T FENG Z N SHIAU W L | 2006 | Molecular and Cellular Cardiology2006，40，2： | 1 |
| 16 | A New Mobile Payment Scheme for Roaming Services显示文摘 | Ren Junn Hwang Sheng Hua Shiau Ding Far Jan | 2007 | Electronic commerce Research and Applications2007，6，3： | 1 |
| 17 | Emphysematous pyelonephritis: Clinical characteristics and prognostic factors显示文摘 | Yu‐Chuan Lu Bing‐Juin Chiang Yuan‐Hung Pong Chung‐Hsin Chen Yeong‐Shiau Pu Po‐Ren Hsueh Chao‐Yuan Huang | 2014 | Int J Urol2014，，3： | 1 |
| 18 | Reflection and critical thinking of humanistic care in medical education显示文摘 | Shiau SJ Chen CH | 2008 | Kaohsiung J Med Sci2008，24，7： | 1 |
| 19 | A VLSI im- plementation of barrel distortion correction for wide- angle camera images显示文摘 | Chen P Y Huang C C Shiau Y H | 2009 | Circuits and Systems II: Ex- press Briefs IEEE Transactions on2009，56，1： | 1 |
| 20 | Fitting drought duration and severity with two-dimensional copulas显示文摘 | SHIAU J T | 2006 | Water Resources Management2006，20，5： | 1 |
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