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107篇 您的检索式：作者名="SHIBUTANI K"

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	题名	作者	年代	出处	被引量
1	Micromolar sodium fluoride mediates anti-osteoclastogenesis in Porphyromonas gingivalis-induced alveolar bone loss显示文摘Osteoclasts are bone-specific multinucleated cells generated by the differentiation of monocyte/macrophage lineage precursors.Regulation of osteoclast differentiation is considered an effective therapeutic approach to the treatment of bone-lytic diseases.Periodontitis is an inflammatory disease characterized by extensive bone resorption. In this study, we investigated the effects of sodium fluoride(Na F) on osteoclastogenesis induced by Porphyromonas gingivalis, an important colonizer of the oral cavity that has been implicated in periodontitis. Na F strongly inhibited the P. gingivalis-induced alveolar bone loss. That effect was accompanied by decreased levels of cathepsin K, interleukin(IL)-1β, matrix metalloproteinase 9(MMP9), and tartrate-resistant acid phosphatase,which were up-regulated during P. gingivalis-induced osteoclastogenesis. Consistent with the in vivo anti-osteoclastogenic effect,Na F inhibited osteoclast formation caused by the differentiation factor RANKL(receptor activator of nuclear factor kB ligand)and macrophage colony-stimulating factor(M-CSF). The RANKL-stimulated induction of the transcription factor nuclear factor of activated T cells(NFAT) c1 was also abrogated by Na F. Taken together, our data demonstrate that Na F inhibits RANKL-induced osteoclastogenesis by reducing the induction of NFATc1, ultimately leading to the suppressed expression of cathepsin K and MMP9.The in vivo effect of Na F on the inhibition of P. gingivalis-induced osteoclastogenesis strengthens the potential usefulness of Na F for treating periodontal diseases.	Ujjal K Bhawal Hye-Jin Lee Kazumune Arikawa Michiharu Shimosaka Masatoshi Suzuki Toshizo Toyama Takenori Sato Ryota Kawamata Chieko Taguchi Nobushiro Hamada Ikuo Nasu Hirohisa Arakawa Koh Shibutani	2015	International Journal of Oral Science2015，7，4：	3
2	Bell pepper fruit fatty acid hydroperoxide lyase is a cytochrome P450(CYP74B)显示文摘	Matsui K Shibutani M Hase T	1996	FEBS Letters1996，394，：	1
3	Significance of preoperative neutrophil-to-lymphocyte ratio as a predictor of prognosis in patients with stage IV colorectal cancer显示文摘	Shibutani M Maeda K Nagahara H	2013	Gall To Kagaku Ryoho2013，40，：	1
4	A high preoperative neutrophil-to-lymphocyte ratio is associated with poor survival in patients with colorectal cancer 显示文摘	Shibutani M Maeda K Nagahara H	2013	Anticancer Res2013，33，8：	1
5	查看详情显示文摘	Shibutani Y Yoshinaga H Yakabe K		0，，：	1
6	Calculation of ocular single-pass modulation transfer function and retinal image simulation from measurements of the polarized double-pass ocular point spread function显示文摘	Kabayashi K Shibutani M Takeuchi G	2004	J Biomed Opt2004，9，1：	1
7	Improvement in strength and electrical conductivity of CuNiSi alloy by aging and cold rolling显示文摘	Suzuki S Shibutani N Mimura K	2006	Journal of Alloys and Compounds2006，417，：	1
8	Critical level of oxygen delivcry in anesthetized man 显示文摘	Shibutani K Komatsu T Kubel K	1983	Crit Care Med1983，11，4：	1
9	Calculation of ocular single-pass modulation transfer function and retinal image simulation from measurements of the polarized double-pass ocular point spread function显示文摘	Kobayashi K Shibutani M Takeuchi G	2004	J Biomed Opt2004，9，1：	1
10	Clinical applicatians of fentanyl pharmacokinetics and pharmacodynamics: roles of fentanyl in anesthesia显示文摘	Shibutani K Katoh T Sakai T	1999	Journal of Anesthesia1999，45，10：	1
11	Wear and oxidation resistance of Al2O3 particle dispersed Al3Ti composite with a nanostructure prepared by pulsed electric current sintering of mechanically alloyed powders显示文摘	UENISHI K MATSUBARA T SHIBUTANI T	2002	Intermetallics2002，10，：	1
12	Bell pepper fruit fatty acid hydroperoxide lyase is a cytochrome P450 (CYP74B)显示文摘	MATSUI K SHIBUTANI M HASE T	1996	FEBS Lett1996，394，：	1
13	Critical level of oxygen delivery in anesthetized man显示文摘	Shibutani K Komatsu T Kubal K	1983	Crit Care Med1983，11，8：	1
14	Effects of high temperature kiln drying on the practical performances of Japanese cedar wood ( Cryptomeria japonica) I: changes in hygroscopicity due to heating显示文摘	OBATAYA E SHIBUTANI S HANATA K	2006	Journal of Wood Science2006，52，1：	1
15	Improvement in strength and electrical conductivity of Cu-Ni-Si alloys by aging and cold rolling 显示文摘	SUZUKI S SHIBUTANI N MIMURA K	2006	Journal of Alloys and Compounds2006，417，：	1
16	Improvement in strength and electrical conductivity of Cu-Ni-Si alloys by aging and cold rolling显示文摘	Suzuki S Shibutani N Mimura K	2006	Journal of Alloys and Compounds2006，417，：	1
17	Pathological assessment of the nervous and male reproductive systems of rat offspring exposed maternally to acrylamide during the gestation and lactation periods-a preliminary study显示文摘	Takahashi M Shibutani M Inoue K	2008	Toxicol Sci2008，33，：	1
18	Elastostatically induced structural disordering in amorphous alloys 显示文摘	PARK K W LEE C M WAKEDA W SHIBUTANI Y FALK M L LEE J C	2008	Acta Mater2008，56，：	1
19	Improvement in strength and electrical conductivity of Cu-Ni-Si alloys by aging and cold rolling显示文摘	Suzuki S Shibutani N Mimura K	2006	J Alloys Comp2006，417，：	1
20	Pathological assessment of the nervous and male reproductive systems of rat offspring exposed maternally to acrylamide during the gestation and lactation periods-a preliminary study显示文摘	Takahashi M Shibutani M Inoue K	2008	Toxicol Sci2008，33，：	1

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