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| 1 | 肿瘤部位或决定结肠癌DNA错配修复功能缺陷的预后影响显示文摘目前对于接受氟尿嘧啶、亚叶酸钙及奥沙利铂(FOLFOX)辅助化疗方案治疗的结肠癌患者,DNA错配修复功能缺陷(dMMR)与预后间的联系尚不明了。美国梅奥诊所的Frank A.Sinicrope博士等人进行了一项临床试验,研究人员在2,580份肿瘤患者的蛋白芯片中,检测到314份(12%)肿瘤患者的蛋白芯片存在 dMMR,其中分别有49.3%及10.6%存在BRAFV600E或KRAS突变。尽管从整体而言,MMR状态并非预后预测因素,但研究同时发现,MMR与原发肿瘤部位及淋巴结分期( N1 v N2)间存在显著的相互作用。对突变情况及协变量校正后,研究人员发现,与准确进行MMR邻近肿瘤相对的dMMR可获得良好的DFS结局,但远端肿瘤的dMMR与良好的DFS结局无关。 N2肿瘤患者不能通过dMMR取得生存获益。BRAFV600 E突变或KRAS突变均为较差DFS的独立相关因素。根据肿瘤部位相互作用观察到的MMR得到了III期结肠癌患者独立队列的验证。 | Sinicrope FA Mahoney MR Smyrk TC | 2013 | 中华结直肠疾病电子杂志2013，2，4： | 27 |
| 2 | Association Between Molecular Subtypes of Colorectal Cancer and Patient Survival显示文摘 | Amanda I. Phipps Paul J. Limburg John A. Baron Andrea N. Burnett-Hartman Daniel J. Weisenberger Peter W. Laird Frank A. Sinicrope Christophe Rosty Daniel D. Buchanan John D. Potter Polly A. Newcomb | 2014 | Gastroenterology2014，，： | 3 |
| 3 | Intraepithelial Effector (CD3 + )/Regulatory (FoxP3 + ) T-Cell Ratio Predicts a Clinical Outcome of Human Colon Carcinoma显示文摘 | Frank A. Sinicrope Rafaela L. Rego Stephen M. Ansell Keith L. Knutson Nathan R. Foster Daniel J. Sargent | 2009 | Gastroenterology2009，，4： | 2 |
| 4 | Molecular Markers Identify Subtypes of Stage III Colon Cancer Associated with Patient Outcomes显示文摘 | Frank A. Sinicrope Qian Shi Thomas C. Smyrk Stephen N. Thibodeau Rodrigo Dienstmann Justin Guinney Brian M. Bot Sabine Tejpar Mauro Delorenzi Richard M. Goldberg Michelle Mahoney Daniel J. Sargent Steven R. Alberts | 2014 | Gastroenterology2014，，： | 2 |
| 5 | bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis显示文摘 | SINICROPE F A RUAN S B CLEARY K R | 1995 | Cancer Res1995，55，2： | 1 |
| 6 | Obesity and breast cancer prog- nosis:weight of the evidence显示文摘 | Sinicrope FA Dannenberg AJ | 2011 | J Clin Oncol2011，29，1： | 1 |
| 7 | Relationship and P-glycoprotein and carcinoembryonic antigen expression in human colon carcinoma to local invasion,DNA ploidy,and disease relapse显示文摘 | Sinicrope FA Hart J Brasitus TA | 1994 | Cancer1994，74，： | 1 |
| 8 | Prognostic impact of microsatellite instability and DNA ploidy in human colon carcinoma patients显示文摘 | Sinicrope FA Rego RL Halling KC | 2006 | Gastroenterology2006，131，3： | 1 |
| 9 | Increased apoptosis accompanies neoplastic development in the human color ectum显示文摘 | Sinicrope T A Roddey G Mcponnell T J | 1996 | Clin Cancer Tes1996，2，12： | 1 |
| 10 | Apoptotie and mitotic indices predict survival rates in lymph node-negative colon carcinomas显示文摘 | Sinicrope FA Hart J Hsu HA | 1999 | Clin Cancer Res1999，5，7： | 1 |
| 11 | Prognostic value of bcl-2 oncoprotein expression in stage II colon carcinoma显示文摘 | Sinicrope FA Hart J Michelassi F | 1995 | Clin Cancer Res1995，1，10： | 1 |
| 12 | Bcl-2 and P53 oncoproteins expression during colorectal tumorigenesis 显示文摘 | Sinicrope FA Ruan SB Cleary KE | 1995 | Cancer Res1995，55，2： | 1 |
| 13 | Prognostic impact of bin, puma, and noxa expression in human colon carcinomas 显示文摘 | Sinicrope FA Rego RL Okumura K | 2008 | CAin Cancer Res2008，14，18： | 1 |
| 14 | Micmsatellite instability accounts for tumor site - related differences in clinicopathologic variables and prognosis in human colon cancers显示文摘 | Sinicrope FA Rego RL Foster N | 2006 | Am J Gastroenterol2006，101，12： | 1 |
| 15 | Bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis显示文摘 | Sinicrope FA Ruan SB Cleary KR | 1995 | Cancer Res1995，55，2： | 1 |
| 16 | Bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis显示文摘 | Sinicrope F A Ruan S B Cleary K R | 1995 | Cancer Res1995，55，2： | 1 |
| 17 | Prognostic impact of microsatellite instability and DNA ploidy in human colon carcinoma patients显示文摘 | Sinicrope FA Rego RL Halling KC | 2006 | Gastroenterology2006，131，3： | 1 |
| 18 | Aherations in cell proliferation and apoptosis in colon cancers with microsatellite instability显示文摘 | Sinicrope FA Rego RL Garrity- Park MM | 2007 | Int J Cancer2007，120，6： | 1 |
| 19 | Chemoprevenfion of colorectal canoer显示文摘 | Sinicrope FA | 2002 | Am J Gastroenterol2002，97，1： | 1 |
| 20 | Apoptotic and mitotic indices predict survival, rates in lymph node-negative colon carcinomas显示文摘 | Sinicrope FA Hart j Hsu HA | 1999 | Clin Cancer Res1999，5，7： | 1 |
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