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| 1 | 难治性疼痛和高血压在急性B型主动脉夹层中的重要性:国际急性主动脉夹层登记的意见显示文摘急性B型主动脉夹层患者,可表现出对药物治疗无效的反复、难治性疼痛和(或)难治性高血压,当出现这些症状时有时可作为介入治疗的指征。研究者利用国际急性主动脉夹层登记(international registry of a-cute aortic dissection,IRAD)的资料调查难治性疼痛和(或)难治性高血压对急性B型主动脉夹层患者临床转归的影响。 | 张玲玉 叶鹏 Trimarchi S Eagle KA Nienaber CA Pyeritz RE Jonker FH Suzuki T O'Gara PT Hutchinson SJ Rampoldi V Grassi V Bossone E Muhs BE Evangelista A Tsai TT Froehlich JB Cooper JV Montgomery D Mein-hardt G Myrmel T Upchurch GR Sundt TM Issel-bacher EM | 2010 | 中华高血压杂志2010，18，12： | 4 |
| 2 | LMP2-DC Vaccine Elicits Specific EBV-LMP2 Response to Effectively Improve Immunotherapy in Patients with Nasopharyngeal Cancer显示文摘Objective To evaluate the safety and effectiveness of a vaccine based on latent membrane protein 2(LMP2)modified dendritic cells(DCs)that boosts specific responses of cytotoxic T lymphocytes(CTLs)to LMP2 before and after intradermal injection in patients with nasopharyngeal carcinoma(NPC).Methods DCs were derived from peripheral blood monocytes of patients with NPC.We prepared LMP2-DCs infected by recombinant adenovirus vector expressing LMP2(rAd-LMP2).NPC patients were immunized with 2×105 LMP2-DCs by intradermal injection at week 0 and after the second and fourth weeks.Specific responses to LMP2 were detected by enzyme-linked immunospot(ELISPOT)assay at week 0 and at the fifth and eighth weeks.Local clinicians performed the follow-up and tracking of patients.Results We demonstrated that DCs derived from monocytes displayed typical DC morphologies;the expression of LMP2 in the LMP2-DCs vaccine was confirmed by immunocytochemical assay.Twenty-nine patients with NPC were enrolled in this clinical trial.The LMP2-DCs vaccine was well tolerated in all of the patients.Boosted responses to LMP2 peptide sub-pools were observed in 18 of the 29 patients with NPC.The follow-up data of 29 immunized patients from April,2010 to April 2015 indicated a five-year survival rate of 94.4%in responders and 45.5%in non-responders.Conclusion In this pilot study,we demonstrated that the LMP2-DCs vaccine is safe and effective in patients with NPC.Specific CTLs responses to LMP2 play a certain role in controlling and preventing the recurrence and metastasis of NPC,which warrants further clinical testing. | ZENG Yi SI Yong Feng LAN Gui Ping WANG Zhan ZHOU Ling TANG Min Zhong SJ O`Brien LAN Jiao ZHOU Xiang Yang WANG Yong Li TANG Juan ZHOU Zhi Xiang DU Hai Jun LIN Hui | 2020 | Biomedical and Environmental Sciences2020，33，11： | 2 |
| 3 | Arthroseopie assessment of the medial collateral ligament complex of the elbow 显示文摘 | Field LD Callaway GH O'Brien SJ | 1995 | Am Sports Med1995，4，： | 1 |
| 4 | Clinical experience with cell salvage in obstetrics:4 cases from one UK centre显示文摘 | Freites O Krishnan S | 2002 | Int J Obstet Anesth2002，11，2： | 1 |
| 5 | Childhood hemolytic uremic syndrome,United Kingdom and Ireland显示文摘 | Lynn RM O′brien SJ Taylor CM | 2005 | Emerg Infect Dis2005，11，4： | 1 |
| 6 | EGF165 b, an endogenous C-terminal splice variant of VEGF, inhibits ret- inal neovascularization in mice显示文摘 | Konopatskaya O Churchill AJ Harper SJ | 2006 | Mol Vis2006，12，： | 1 |
| 7 | Randomized phase Ⅱ study of weekly irinotecan/carboplatin with or without cetuximab in patients with metastatic breast cancer ( abstract 308 ) 显示文摘 | O' Shaughnessy J Weckstein DJ Vukelja SJ | 2007 | Breast Cancer Res Treat2007，106，1： | 1 |
| 8 | The effects of insulin,and insulin-like growth factors Ⅰ and Ⅱ on human ovarian follicles in long-term culture显示文摘 | Louhio H Hovatta O Sj(o)berg J | 2000 | Mol Hum Reprod2000，6，8： | 1 |
| 9 | Nutritional immuncanoduhtion of acutepan-creatitis显示文摘 | Hegazi RA O'Keefe SJ | 2007 | Curr Gastznenteml Rep2007，9，2： | 1 |
| 10 | Humanization of an anti- vascularer endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders显示文摘 | Presta LG Chen H O'Connor SJ | 1997 | Cancer Res1997，57，20： | 1 |
| 11 | A phase II muhicenter study of ipilimumab with or without dacarbazine in chemotherapy- naive patients with advanced melanoma 显示文摘 | Hersh EM O'Day SJ Powderly J | 2011 | Invest New Drugs2011，29，3： | 1 |
| 12 | Concurrent conditions and human Listeriosis,England, 1999-2009显示文摘 | Mook P O Brien SJ Gillespie IA | 2011 | Emerging Infectious Diseases2011，17，1： | 1 |
| 13 | The role of liverderived insulin-like growth factor-Ⅰ显示文摘 | Ohlsson C Mohan S Sj(o)gren K | | 0，，05： | 1 |
| 14 | The consensus coding sequences of human breast and colorectal cancers显示文摘 | Sj(o)blom T Jones S Wood LD | | 0，，5797： | 1 |
| 15 | 一般人群中发生心力衰竭的10年风险方程显示文摘目前急需能减轻心力衰竭负担的一级预防策略,但未见实用有效的风险预测工具。该研究旨在得出一个计算心力衰竭事件发生的10年风险方程。研究者根据7个社区队列,至少12年随访的个体水平数据,推导并验证了心力衰竭的种族和性别特异性10年风险方程。1985-2000年间招募年龄30~79岁在基线时无心血管病的研究对象,创建一个集合队列并随机分组以进行方程推导和内部验证。在另两个队列中也评估了该模型的性能。 | Khan SS Ning H Shah SJ Yancy CW Carnethon M Berry JD Mentz RJ O’Brien E Correa A Suthahar N de Boer RA Wilkins JT Lloyd-Jones DM 刘青 叶鹏 | 2019 | 中华高血压杂志2019，27，6： | 1 |
| 16 | Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin - LR 显示文摘 | Nishiwaki R Tetsuya O Nishiwaki SJ | 1992 | J Cancer Res Clin Oncol1992，118，6： | 1 |
| 17 | Circular chromosome conformation capture(4C) uncovers extensive networks of epigenetically regulated intra-and interchromosomal interactions显示文摘 | Zhao Z Tavoosidana G Sj(o)linder M | 2006 | Nat Genet2006，38，11： | 1 |
| 18 | Measuring fracture orientation at exposed rock faces by using a non-reflector total station显示文摘 | FENG Q SJ(O)GREN P STEPHANSSON O | 2001 | Engineering Geology2001，59，12： | 1 |
| 19 | The influence of hal genotype on AIDS 显示文摘 | Carrington M O' Brien SJ | 2003 | AnnuRev Med2003，54，： | 1 |
| 20 | Dynamic helical computed tomography scan accurately detects hemorrhage in patients with pelvic fracture显示文摘 | Pereira SJ O'Brien DP Luchette FA | 2000 | Surgery2000，128，6： | 1 |
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