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| 1 | Induction of mucosal and systemic immune response by single-dose oral immunization with biodegradable microparticles containing DNA encoding HBsAg显示文摘 | He XW Wang F Jiang L Li J Liu SK Xiao ZY Jin XQ Zhang YN He Y Li K Guo YJ Sun SH | 2005 | 第二军医大学学报2005，26，10： | 5 |
| 2 | 在脑病理状态下星形胶质细胞介导的突触重塑显示文摘星形胶质细胞是胶质细胞的主要类型,对神经元突触间的信号传递和联系起到反馈作用,构成'三重突触结构'。在大脑发育的过程中,星形胶质细胞的代谢型谷氨酸受体介导钙离子波并释放胶质递质或突触发生分子,介导神经元.胶质细胞间的联系,但在成年大脑中,尚不清楚是否存在此信号通路。但越来越多的证据显示,当成年大脑处于病理状态下,成熟的星形胶质细胞也重新表现出非成熟星形胶质细胞的表型。星形胶质细胞表型的这种非成熟转变可以导致神经环路和突触的重塑。在本综述中,笔者总结了大脑发育过程中星形胶质细胞介导的突触重塑,讨论了成年脑病理过程中非成熟星形胶质细胞信号通路的重现,并重点讨论这些信号通路对病理过程中与脑功能改变有关的突触连接重塑的意义。 | Kim SK Nabekura J Koizumi S 唐颖馨(编译) | 2017 | 神经损伤与功能重建2017，12，4： | 4 |
| 3 | Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC. | Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 4 | Down-regulation of surviving by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth显示文摘 | Chen J Wu W Tahir SK | 2000 | Neoplasia2000，2，3： | 2 |
| 5 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 6 | Effect of radiographic contrast media on endothelium derived nitric oxide-dependent renal vasodilatation显示文摘 | Oldroyd S Haylor J | 1997 | Br J Radiol1997，70，： | 1 |
| 7 | RNA interference targeting Fas protects mice from fulminant hepatitis显示文摘 | Song E Lee SK Wang J | 2003 | Nat Med2003，9，： | 1 |
| 8 | Antiplatelet therapy mitigates cardiac remodeling and dysfunction in congestive heart failure due to myocardial infarction显示文摘 | Sanganalmath SK Barta J Takeda N | 2008 | Can J Physiol Pharmacol2008，86，4： | 1 |
| 9 | Tricuspid valve repair: Durability and risk factors for failure 显示文摘 | McCarthy PM Bhudia SK Rajeswaran J | 2004 | J Thorac Cardiovase Surg2004，127，： | 1 |
| 10 | Early exposure to anesthesia and learning dis- abilities in a population-based birth cohort 显示文摘 | Wilder RT Flick RP Sprung J Katusic SK Barbaresi WJ Mickelson C | 2009 | Anesthesiology2009，110，4： | 1 |
| 11 | Radioprotective effeats of diltiazem on cytogenetic damage and survival in gamma ray exposed mice显示文摘 | Goel HC Ganguly SK Prasad J | 1996 | Indian J Expertal Bio1996，34，12： | 1 |
| 12 | Efficacy of sucrose and milk chocolate product or dried porcine solubles to increase feed intake and impmve performance of lactating sows显示文摘 | Johnston L J Pettigrew J E Bmdoo SK | 2003 | Anim Sci2003，81，： | 1 |
| 13 | Individual differ- ences in reactivity to social stress predict susceptibility and re- silience to a depressive phenotype:role of corticotropin-releas-ing factor显示文摘 | Wood SK Walker HE Valentino R J | 2010 | Neuroendocrinology2010，151，4： | 1 |
| 14 | Accuracy of PET/CT in characterization of solitary pulmonary lesions 显示文摘 | Kim SK Allen-Auerbach M Goldin J | 2007 | J NuclMed2007，48，： | 1 |
| 15 | Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water显示文摘 | Song SK Sun SW Ramsbotton M J | 2002 | Neuroimage2002，17，： | 1 |
| 16 | Effect of unplanned extubation on outcome of mechanical ventilation显示文摘 | Epstein SK Nevins ML Chung J | 2000 | Am J Respir Crit Care Med2000，161，6： | 1 |
| 17 | High-flow nasal cannulae for respiratory support of preterm infants: a review of the evi- dence 显示文摘 | Manley B J Dold SK Davis PG | 2012 | Neonatology2012，102，4： | 1 |
| 18 | Blocking of monocyte-associated B7-H1 (CD274)enhances HCV-specific T cell immunity in chronic hepatitis C infection 显示文摘 | Jeong HY Lee Y J Seo SK | 2008 | J Leukoc Biol2008，83，3： | 1 |
| 19 | In vitro susceptibilities of aerobic and facultative anaerobic Gram -negative bacilli from patients with intra - abdominal infections worldwide from 2005-2007: resrlts from the SMART study 显示文摘 | Hawser SP Bouchillon SK Hoban D J | 2009 | Int J Antimicrob Agents2009，34，6： | 1 |
| 20 | Characteristics and outcome for very elderly patients (≥ 80 years) admitted to a respiratory care center in Taiwan显示文摘 | Su J Lin CY Chen SK | | 0，，： | 1 |
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