|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | 健康领域的文化能力显示文摘1背景
尽管人类对其他社会的兴趣纵贯历史的各个阶段,但是检验不同文化概念对人类健康实践的影响从20世纪才开始,当时是伴随着长期的人类学田野调查产生的,这些田野调查揭露了不同文化之间相关卫生实践的多样性、复杂性和连续性。 | Napier A D Ancarno C Butler B Calabrese j Chater A Chatterjee H Guesnet F Home R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams AC Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，2： | 5 |
| 3 | FRP-Strengthened RC beams( I ):Review of debonding strength models 显示文摘 | Smith S T Teng J G | 2002 | Engineering Structures2002，，24： | 2 |
| 4 | Pentraxin binding to isolated rat liver nuclei显示文摘 | Shephard E G Smith P J Coetzee S | 1991 | Biochem J1991，279，1： | 2 |
| 5 | 文化、不平等性与卫生服务提供显示文摘1动态不平等性对基层医疗卫生人力的影响
政治、社会、文化、专业群体皆建立在一致且常规的人类行为之上。当遭受巨大变革和内外压力时,这些群体会变得十分脆弱。尤其在动荡时期,这些群体往往更关注社会和文化的差异性,而非二者的一致性。尽管社会中的个体思维和行为会呈现较大的差异,但对健康的感知具有统一性,并在更广范围人群内尤为突出,这主要归因于文化价值观的作用。广义的文化心态会随着时间和地理位置的不同而不同,就像健康的社会决定因素也会因文化类型的不同而产生差异。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，3： | 2 |
| 6 | 中低收入国家的慢性病:背景、决定因素与卫生政策显示文摘近年来,中低收入国家慢性病不断上升的趋势及其产生的影响受到广泛关注,但有关这种上升趋势的解释和说明大多基于高收入国家的慢性病发展史,但其所经历的发展历程与中低收入国家并不完全相同。本文对这些差异进行评价,以更好地理解中低收入国家慢性病的流行趋势,并对慢性病决定因素的相关理论加以讨论,为慢性病的防控提供循证支持。此外,本文将慢性病防控政策看作是降低人口患病风险和个体易感性的重要干预手段,并讨论了中低收入国家需要开展的相关政策研究。在此基础上进一步强调了加强初级卫生保健改革的必要性,并将其作为降低慢性病流行趋势的一项重要政策。 | Miranda J J Kinra S Casas J P Davey Smith G Ebrahim S | 2013 | 中国卫生政策研究2013，6，10： | 2 |
| 7 | Crystal structure of Argonaute and its implications for RISC slicer activity 显示文摘 | Song J J Smith S K Hannon G J | 2004 | Science2004，305，5689： | 1 |
| 8 | Pre-oxygenation and the parturient patient 显示文摘 | Russell G N Smith C L Snowdon S L | 1987 | Anaesthesia1987，42，： | 1 |
| 9 | Pharmacokinetics of melamine in pigs following intravenous administration 显示文摘 | Baynes B E Smith G Mason S E | 2008 | Food Chem Toxicol2008，6，： | 1 |
| 10 | Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis显示文摘 | Clifford G M Smith J S Plummer M | 2003 | Br J Cancer2003，88，1： | 1 |
| 11 | A method for analyzing plant architecture as it relates to fruit qualibty using three-dimensional computer graphics显示文摘 | Smith G S Curtis J P Edwards C M | 1992 | Annals of Botany1992，70，： | 1 |
| 12 | Measuring thermal and mechanical stresses on optical fiber in a DC module using fiber Bragg gratings显示文摘 | Glaesemann G S Smith J A Clark D A | 2005 | Journal of Lightwave Technology2005，23，11： | 1 |
| 13 | Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor 显示文摘 | Goodwin R G Din W S Davis Smith T | 1993 | Eur J Immunol1993，23，10： | 1 |
| 14 | Accurate computation of the radiation from simple antennas using the finite- difference time- domain method显示文摘 | Maloney J G Smith G S Scott W R JR | 1990 | IEEE Trans Antennas and Propagat1990，38，7： | 1 |
| 15 | Effects of water stress on fruit quality attributes of Kiwifruit显示文摘 | Miller S A Smith G S Bolding H L | 1998 | Annals of Botany1998，81，： | 1 |
| 16 | Elliptical flexure hinges显示文摘 | Smith T S Badami V G | 1997 | Rev Sci Instrum1997，68，3： | 1 |
| 17 | Factors influencing changes in articular cartilage follow- ing hemiarthroplasty in sheep显示文摘 | van der Meulen M C Beaupre G S Smith R L | 2002 | J Orthop Res2002，20，4： | 1 |
| 18 | Invasive Pneumococcal Disease in Children 5 Years After Conjugate Vaccine Introduction - Eight States, 1998-2005显示文摘 | Reingold A Hadler J Farley M M Harrison L Lynfield R Lexau C Bennett N Thomas A Craig A S Smith P J Beall B Whitney C G Moore M Pilishvili T | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，6： | 1 |
| 19 | A semiempirical method for analysis of the reflectance spectra of binary mineral mixtures显示文摘 | Johnson P E Smith M O Taylor G S | 1983 | Journal of Geophysical Research:Solid Earth1983，88，4： | 1 |
| 20 | Attitudes and bar- riels to incident reporting:A collaborative hospital study 显示文摘 | Evans S M Berry J G Smith B J | 2006 | Qual Saf Health Care2006，15，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员