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| 1 | Computed tomography scans of paranasal sinuses before functional endoscopic sinus surgery显示文摘This review aims to familiarize the radiologist with the common types of sinus surgery including their indications and techniques.We also illustrate how surgeons interpret 3D sinus anatomy when evaluating computed tomography(CT)studies.Preoperative evaluation by CT is mandatory for all patients undergoing functional endoscopic sinus surgery(FESS).In the past decade in particular,CT of the paranasal sinuses has become a roadmap for FESS.The radiologist's goal is to report on five key points:the extent of sinus opacification,opacification of sinus drainage pathways,anatomical variants,critical variants,and condition of surrounding soft tissues of the neck,brain and orbits.We present a systematic approach to the use of coronal,axial,and sagittal images in CT evaluation before FESS. | Emma C Cashman Peter J MacMahon David Smyth | 2011 | World Journal of Radiology2011，3，8： | 10 |
| 2 | Role of(~(18)F)2-fluoro-2-deoxyglucose positron emission tomography in upper gastrointestinal malignancies显示文摘The role of whole-body FDG [(~(18)F)2-fluoro-2-deoxy-glucose] positron emission tomography(PET)scan-ning as an imaging modality in the management of patients with malignancy has evolved enormously over the past two decades.FDG-PET has demonstrated signifi cant effi cacy in the staging,prognostication and detection of occult metastatic disease in malignancies of the gastrointestinal tract,in addition to assessment of the response to cytotoxic chemotherapy in a more timely manner than has traditionally been possible by more conventional imaging tools.The sensitivity and specif icity of FDG-PET for the detection and staging of malignancy depend not only on the site and size of the primary tumor and metastases,but also on histologi-cal cell type,reflecting underlying disparities in glucose metabolism.The metabolic response to neo-adjuvant chemotherapy or to chemo-radiotherapy in cancers of the gastro-esophageal junction or stomach has been demonstrated in several prospective studies to correlate signifi cantly with both the histological tumor response to treatment and with consequent improvements in overall survival.This may offer a future paradigm ofpersonalized treatment based on the PET response to chemotherapy.FDG-PET has been less successful in efforts to screen for and detect recurrent upper gastro-intestinal malignancies,and in the detection of low vol-ume metastatic peritoneal disease.Efforts to improve the accuracy of PET include the use of novel radiotrac-ers such as(~(18)F)FLT(3-deoxy-3-fluorothymidine)or 11C-choline,or fusion PET-CT with concurrent high-res-olution computed tomography.This review focuses on the role of FDG-PET scanning in staging and response assessment in malignancies of the upper gastrointesti-nal tract,specif ically gastric,esophageal and pancreas carcinoma. | Elizabeth C Smyth Manish A Shah | 2011 | World Journal of Gastroenterology2011，17，46： | 6 |
| 3 | Colorectal liver metastases: Current management and future perspectives显示文摘The liver is the commonest site of metastatic disease for patients with colorectal cancer,with at least 25%developing colorectal liver metastases(CRLM)during the course of their illness.The management of CRLM has evolved into a complex field requiring input from experienced members of a multi-disciplinary team involving radiology(cross sectional,nuclear medicine and interventional),Oncology,Liver surgery,Colorectal surgery,and Histopathology.Patient management is based on assessment of sophisticated clinical,radiological and biomarker information.Despite incomplete evidence in this very heterogeneous patient group,maximising resection of CRLM using all available techniques remains a key objective and provides the best chance of long-term survival and cure.To this end,liver resection is maximised by the use of downsizing chemotherapy,optimisation of liver remnant by portal vein embolization,associating liver partition and portal vein ligation for staged hepatectomy,and combining resection with ablation,in the context of improvements in the functional assessment of the future remnant liver.Liver resection may safely be carried out laparoscopically or open,and synchronously with,or before,colorectal surgery in selected patients.For unresectable patients,treatment options including systemic chemotherapy,targeted biological agents,intraarterial infusion or bead delivered chemotherapy,tumour ablation,stereotactic radiotherapy,and selective internal radiotherapy contribute to improve survival and may convert initially unresectable patients to operability.Currently evolving areas include biomarker characterisation of tumours,the development of novel systemic agents targeting specific oncogenic pathways,and the potential reemergence of radical surgical options such as liver transplantation. | Jack Martin Angelica Petrillo Elizabeth C Smyth Nadeem Shaida Samir Khwaja HK Cheow Adam Duckworth Paula Heister Raaj Praseedom Asif Jah Anita Balakrishnan Simon Harper Siong Liau Vasilis Kosmoliaptsis Emmanuel Huguet | 2020 | World Journal of Clinical Oncology2020，11，10： | 5 |
| 4 | Emerging molecular targets and therapy for cholangiocarcinoma显示文摘Cholangiocarcinoma(CCA) is a rare cancer arising from the biliary tree with a poor prognosis and limited therapeutic options. Recent large scale molecular characterisation studies have identified recurrent genetic alterations in CCA which may be amenable to therapeutic targeting. In this review we explore the genomic landscape of CCA and examine results from trials of molecularly targeted agents and immunotherapy in this disease. Challenges in CCA diagnosis, treatment and trial design are discussed and we reflect on future directions which may lead to improved outcomes for CCA patients. | Hamzeh Kayhanian Elizabeth C Smyth Chiara Braconi | 2017 | World Journal of Gastrointestinal Oncology2017，9，7： | 5 |
| 5 | Site of intestinal hydrolysis of glycylglycine显示文摘 | Smyth D H | 1971 | Physiological Society1971，，： | 1 |
| 6 | miR 29b Expression is Associated with Disease-Free Survival in Patients with Ovarian Serous Carcinoma 显示文摘 | Flavin R Smyth P Barrett C | 2009 | Int J Gynecol Cancer2009，19，4： | 1 |
| 7 | TRANSPARENT TESTA GLABRA2, a trichome and seed coat development gene of Arabidopsis, encodes a WRKY transcription factor 显示文摘 | Johnson C S Kolevski B Smyth D R | 2002 | The Plant Cell2002，14，： | 1 |
| 8 | A simple fast hybrid pattern-matching algorithm 显示文摘 | FRANEK F JENNINGS C G SMYTH P W F | 2007 | Journal of Discrete Algorithms2007，4，5： | 1 |
| 9 | CD4-regulatory cells in COPD patients 显示文摘 | Smyth LJ Starkey C Vestho J | 2007 | Chest2007，132，： | 1 |
| 10 | Tiny dancers: the integrin-growth factor nexus in angiogenic signaling 显示文摘 | Smyth SS Patterson C | 2002 | J Cell Biol2002，158，1： | 1 |
| 11 | Antiestrogen therapy is active in selected ovarian cancer cases:the use of letrozole in estrogen re- ceptor-positive patients 显示文摘 | Smyth JF Gourley C Walker G | 2007 | Clinical cancer research : an official journal of the American Association for Cancer Research2007，13，12： | 1 |
| 12 | Dispersion of cerussite-rich tailings and plant uptake of heavy metals at historical lead mines near Newtownards,Northern Ireland显示文摘 | Moles N R Smyth D Mather C E Beattie E H Kelly M | 2004 | Applied Earth Science2004，113，： | 1 |
| 13 | Birkhead revised:petrological and geochemical studies of the Birkhead formation, Eromanga Basin显示文摘 | Smyth M Cook A C Philp R P | 1984 | APEA1984，24，1： | 1 |
| 14 | An inventory based analy- sis of Canada's managed forest carbon dynamics, 1990 to 2008 显示文摘 | Stinson G Kurz W A Smyth C E | 2011 | Global Change Biology2011，17，6： | 1 |
| 15 | A Simple Fast Hybrid Pattern-matching Algorithm显示文摘 | Franek F Jennings C G Smyth P W F | 2007 | Journal of Discrete Algorithms2007，4，5： | 1 |
| 16 | The Pittsburgh sleep quality index (PSQI) 显示文摘 | Smyth C | 2000 | Director2000，8，1： | 1 |
| 17 | Gene therapy of lung cancer 显示文摘 | Daniel J C Smythe W R | 2003 | Semin Surg Oncol2003，21，3： | 1 |
| 18 | miR-29b expression is associated with disease-free survival in patient with ovarian serous carcinoma显示文摘 | Flavin R Smyth P Barrett C | 2009 | Int J Gynecol Cancer2009，19，4： | 1 |
| 19 | The role of Bcl-2 family members in non-small cell lung cance显示文摘 | Daniel J C Smythe W R | 2004 | Semin Thorac Cardiovasc Surg2004，16，1： | 1 |
| 20 | Aspirindose for the prevention of cardiovascular disease : a systematic re-view显示文摘 | CAMPBELL C L SMYTH S MONTALESCOT G | 2007 | JAMA2007，297，18： | 1 |
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