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| 1 | Establishing proof of concept:Platelet-rich plasma and bone marrow aspirate concentrate may improve cartilage repair following surgical treatment for osteochondral lesions of the talus显示文摘Osteochondral lesions of the talus are common injuries in the athletic patient. They present a challenging clinical problem as cartilage has a poor potential for healing. Current surgical treatments consist of reparative(microfracture) or replacement(autologous osteochondral graft) strategies and demonstrate good clinical outcomes at the short and medium term follow-up. Radiological findings and second-look arthroscopy however, indicate possible poor cartilage repair with evidence of fibrous infill and fissuring of the regenerative tissue following microfracture. Longer-term follow-up echoes these findings as it demonstrates a decline in clinical outcome. The nature of the cartilage repair that occurs for an osteochondral graft to become integrated with the native surround tissue is also of concern. Studies have shown evidence of poor cartilage integration,with chondrocyte death at the periphery of the graft, possibly causing cyst formation due to synovial fluid ingress. Biological adjuncts, in the form of platelet-rich plasma(PRP) and bone marrow aspirate concentrate(BMAC), have been investigated with regard to their potential in improving cartilage repair in both in vitro and in vitro settings. The in vitro literature indicates that these biological adjuncts may increase chondrocyte proliferation as well as synthetic capability, while limiting the catabolic effects of an inflammatory joint environment. These findings have been extrapolated to in vitro animal models, with results showing that both PRP and BMAC improve cartilage repair. The basic science literature therefore establishes the proof of concept that biological adjuncts may improve cartilage repair when used in conjunction with reparative and replacement treatment strategies for osteochondral lesions of the talus. | Niall A Smyth Christopher D Murawski Amgad M Haleem Charles P Hannon Ian Savage-Elliott John G Kennedy | 2012 | World Journal of Orthopedics2012，3，7： | 8 |
| 2 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 3 | A modified Prony algorithmfor exponential function fitting显示文摘 | Osborne M R Smyth G | 1995 | SIAM J Comput1995，16，： | 2 |
| 4 | The role of serotonin receptor alleles and environmental stressors in the development of post‐concussive symptoms after pediatric mild traumatic brain injury显示文摘 | Kim Smyth Sandeep S Sandhu Susan Crawford Deborah Dewey Jillian Parboosingh Karen M Barlow | 2014 | Dev Med Child Neurol2014，，1： | 2 |
| 5 | Multiple physiological functions for multidrug transporter P glycoprotein显示文摘 | Johnstone R W Ruefli A A Smyth M J | 2000 | Trends Biochem Sci2000，25，1： | 1 |
| 6 | Diurnal variations in hydraulic conductivity and root pressure can be correlated with the expression of putative aquaporlns in the roots of Lotus japonicus显示文摘 | HENZLER T WATERHOUSE R N SMYTH A J CARVAJAL M COOKE D T SCHAFFNER A R STEUDLE E CLARKSOND T | 1999 | Planta1999，210，： | 1 |
| 7 | Adaptation-Guided Retrieval: Questioning the Similarity Assumption in Reasoning 显示文摘 | SMYTH B KEANE M T | 1998 | Artificial Intelligence1998，102，2： | 1 |
| 8 | Hypoxia-driven immuno- suppression contributes to the pre-metastatic niche 显示文摘 | Seeneay J Parker BS Smyth M J | 2013 | Oneo Im- munalogy2013，2，22： | 1 |
| 9 | Ramucirumab: successfully targeting angiogenesis in gastric cancer 显示文摘 | JAVLE M SMYTH EC CHAU I | 2014 | Clin Cancer Res2014，20，23： | 1 |
| 10 | Charge motion in ferroelectric thin films显示文摘 | SMYTH D M | 1991 | Ferroelectrics1991，116，： | 1 |
| 11 | Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells 显示文摘 | Takeda K Hayakawa Y Smyth M J | 2001 | Nat Med2001，7，1： | 1 |
| 12 | Epidural versus nonepidural or no anal-gesia in labour Cochrane Database of Systematic显示文摘 | Anim-Somuah M Smyth RMD Howell CJ | | 0，，： | 1 |
| 13 | Myocardialnecrosis induced by temporary occlusion of coronary atery in the dog 显示文摘 | Jennings R B Sommers H M Smyth G A | 1960 | Arch Pathol1960，70，1： | 1 |
| 14 | Ligand Electronic Effects in Enantioselective Diethylzinc Additions显示文摘 | Smyth M | 2003 | Synlett2003，1，： | 1 |
| 15 | Dispersion of cerussite-rich tailings and plant uptake of heavy metals at historical lead mines near Newtownards,Northern Ireland显示文摘 | Moles N R Smyth D Mather C E Beattie E H Kelly M | 2004 | Applied Earth Science2004，113，： | 1 |
| 16 | Crystalstructure of fusion proteins with large-affinity tags显示文摘 | Smyth D R Mrozkiewicz M K McGragh W J | 2003 | Protein Sci2003，12，7： | 1 |
| 17 | New aspects of natural-killer-cell surveillance and therapy of cancer显示文摘 | Smyth M J Hayakawa Y Takeda K | 2002 | Nat Rev Cancer2002，2，11： | 1 |
| 18 | Simultaneous Determination of Products and Intermediates of L-DOPA Oxidation Using CapillaryElectrophoresis with Diode-Array Detection显示文摘 | Robinson G M Smyth M R | 1997 | Analyst1997，122，： | 1 |
| 19 | Multi-residue analysis for β-agonists in urine and liver samples using mixed phase columns with determination by radioimmunoassay 显示文摘 | Collins S O'Keeffe M Smyth MR | 1994 | Analyst1994，119，： | 1 |
| 20 | Birkhead revised:petrological and geochemical studies of the Birkhead formation, Eromanga Basin显示文摘 | Smyth M Cook A C Philp R P | 1984 | APEA1984，24，1： | 1 |
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