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| 1 | Novel mechanisms in functional dyspepsia显示文摘机能性消化不良(FD ) 是多重病原的机制涉及的高度流行却异构的混乱。尽管有许多研究,调查了各种各样的 pathophysiologic 机制,与 FD 联系的内在的随便小径仍然保持阴暗。与 FD 联系的当前建议的 pathophysiologic 机制包括基因危险性,推迟以及加速胃的倒空的、内脏的超敏性到酸或机械膨胀,损害胃的住所,反常底的的局面的收缩,反常 antro 十二指肠的活动性,急性、长期的感染,和精神分析社会 comorbidity。位于 FD 下面的畸形的更大的理解可以导致改进管理。这篇社论的目的是在机能性消化不良提供当前的 pathophysiologic 概念的批评概述。 | Rok Son Choung Nicholas J Talley | 2006 | World Journal of Gastroenterology2006，12，5： | 25 |
| 2 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 3 | Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage显示文摘 | Kyoung-Han Kim Yun Hye Kim Joe Eun Son Ju Hee Lee Sarah Kim Min Seon Choe Joon Ho Moon Jian Zhong Kiya Fu Florine Lenglin Jeong-Ah Yoo Philip J Bilan Amira Klip Andras Nagy Jae-Ryong Kim Jin Gyoon Park Samer MI Hussein Kyung-Oh Doh Chi-chung Hui Hoon-Ki Sung | 2017 | Cell Research2017，27，11： | 9 |
| 4 | Clinical course of subepithelial lesions detected on upper gastrointestinal endoscopy显示文摘AIM:To evaluate the natural history of subepithelial lesions.METHODS:We reviewed the medical records of 104 159 patients who underwent upper gastrointestinal endoscopy at the Center for Health Promotion of Samsung Medical Center between 1996 and 2003.Subepithelial lesions were detected in 795 patients(0.76%);252 patients were followed using upper gastrointestinal endoscopy for 82.5 ± 29.2 mo(range,12-160 mo;median,84 mo;1st quartile,60 mo;3rd quartile,105 mo).The median interval of follow-up endoscopy was 12 mo(range,6-105 mo;1st quartile,12 mo;3rd quartile,24 mo).RESULTS:The mean patient age was 53 years(range,22-80 years),and the male-to-female ratio was 2.36:1(177/75).The lesion size at initial measurement averaged 8.9 mm(range,2-25 mm;median,8 mm;1st quartile,5 mm;3rd quartile,10 mm).Of the 252 lesions,244(96.8%) were unchanged and 8(3.2%) were significantly increased in size(from 12.9 ± 6.0 to 21.2 ± 12.2 mm) after a mean interval of 59.1 ± 27.5 mo(range,12-86 mo).Surgical resection of lesions was performed when the lesions were ≥ 3 cm in diameter.Two lesions were diagnosed as gastrointestinal stromal tumors with an intermediate or high risk of malignancy and one lesion was classified as a schwannoma.CONCLUSION:Most small subepithelial lesions do not change as shown by endoscopic examination,and regular follow-up with endoscopy may be considered in small,subepithelial lesions,especially lesions < 1 cm in size. | Yeun Jung Lim Hee Jung Son Jong-Soo Lee Young Hye Byun Hyun Joo Suh Pool Lyul Rhee Jae J Kim Jong Chul Rhee | 2010 | World Journal of Gastroenterology2010，16，4： | 6 |
| 5 | Ultrafast photonic PCR显示文摘Nucleic acid amplification and quantification via polymerase chain reaction(PCR)is one of the most sensitive and powerful tools for clinical laboratories,precision medicine,personalized medicine,agricultural science,forensic science and environmental science.Ultrafast multiplex PCR,characterized by low power consumption,compact size and simple operation,is ideal for timely diagnosis at the point-of-care(POC).Although several fast/ultrafast PCR methods have been proposed,the use of a simple and robust PCR thermal cycler remains challenging for POC testing.Here,we present an ultrafast photonic PCR method using plasmonic photothermal light-to-heat conversion via photon–electron–phonon coupling.We demonstrate an efficient photonic heat converter using a thin gold(Au)film due to its plasmon-assisted high optical absorption(approximately 65%at 450 nm,the peak wavelength of heat source light-emitting diodes(LEDs)).The plasmon-excited Au film is capable of rapidly heating the surrounding solution to over 150℃ within 3 min.Using this method,ultrafast thermal cycling(30 cycles;heating and cooling rate of 12.7960.93℃ s^(-1) and 6.660.29℃ s^(-1),respectively)from 55℃(temperature of annealing)to 95℃(temperature of denaturation)is accomplished within 5 min.Using photonic PCR thermal cycles,we demonstrate here successful nucleic acid(λ-DNA)amplification.Our simple,robust and low cost approach to ultrafast PCR using an efficient photonic-based heating procedure could be generally integrated into a variety of devices or procedures,including on-chip thermal lysis and heating for isothermal amplifications. | Jun Ho Son Byungrae Cho SoonGweon Hong Sang Hun Lee Ori Hoxha Amanda J Haack Luke P Lee | 2015 | Light(Science & Applications)2015，4，1： | 2 |
| 6 | Improving the performance of time-constrained workflow processing显示文摘 | Son J H Kim M H | 2001 | The Journal of System and Software2001，58，3： | 1 |
| 7 | Preparation of platinum- doped hollow spheres and their electrocatalytic activity in water electrolysis 显示文摘 | Kim H R Chattopadhyay J Son J I | 2008 | Korean Journal of Chemical Engineering2008，25，4： | 1 |
| 8 | Exosomes:a new delivery system for tumor antigens in cancer immunotherapy显示文摘 | CHO J A YEO D J SON H Y | 2005 | Int J Cancer2005，114，4： | 1 |
| 9 | A study on prediction of bead height in robotic arc welding using a neural network 显示文摘 | KIM S SON J S PARK C E | 2002 | Journal of Materials Processing Technology2002，130，2： | 1 |
| 10 | Surface modification by silver coating for improving electrochemi cal properties of LiFePO4显示文摘 | Park K S Son J T Chung H T | 2004 | Solid State Communications2004，129，： | 1 |
| 11 | Surface modification by silver coating for improving electrochemical properties of LiFePO4 显示文摘 | Park K S Son J T Chung H T | 2004 | Solid State Communications2004，129，5： | 1 |
| 12 | Falsely increased bispectral index score during deep hypothermic circulatory arrest in cardiac surgery显示文摘 | Bang J O Son H J Lee E H | 2012 | Korean journal of anesthesiology2012，63，4： | 1 |
| 13 | Morphology devel- opment and crystallization behavior of poly ( ethylene tereph- thalate)/poly ( trimethylene terephthalate ) blends 显示文摘 | KIM G S SON J M LEE J K | 2010 | Eur Polym J2010，46，8： | 1 |
| 14 | Integrated cost and schedule control in the Korean construction industry based on a modified work-packaging model显示文摘 | Park C Lee S Son J | 2008 | NRC Research Press Web2008，13，35： | 1 |
| 15 | Delayed feedback on the dy- namical model of a financial system显示文摘 | SON W S PARK Y J | 2011 | Chaos Soil- tons & Fractals2011，44，45： | 1 |
| 16 | Acrylamide alters cytoskeletal protein level in rat sciatic nerves 显示文摘 | Yu S Son F Yu J | 2006 | Neurochem Res2006，31，： | 1 |
| 17 | Aluminum agglomerationreduction in a composite propellant using tailored Al/PTFEparticles显示文摘 | Sippel T R Son S F Groven L J | 2014 | Combustion and Flame2014，161，1： | 1 |
| 18 | The Effects of La Substitution on Fer-roelectric Domain Structure and Multiferroic Properties ofEpitaxially Grown BiFe03 Thin Films 显示文摘 | KIM W H SON J Y | 2013 | Applied PhysicsLetters2013，103，13： | 1 |
| 19 | Synthesis of LiFePO4 by co-precipitation and microwave heating 显示文摘 | PARK K S SON J T CHUNG H T | 2003 | Electrochemistry Communications2003，5，10： | 1 |
| 20 | Hydrogen production from carbon dioxide reforming of methane over highly active and stable MgO promoted Co -Ni/γ-Al2O3 catalyst显示文摘 | SON I H LEE S J ROH H S | 2014 | Science Direct2014，39，： | 1 |
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