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| 1 | Genetic algorithms for computational materials discovery accelerated by machine learning显示文摘Materials discovery is increasingly being impelled by machine learning methods that rely on pre-existing datasets.Where datasets are lacking,unbiased data generation can be achieved with genetic algorithms.Here a machine learning model is trained on-the-fly as a computationally inexpensive energy predictor before analyzing how to augment convergence in genetic algorithm-based approaches by using the model as a surrogate.This leads to a machine learning accelerated genetic algorithm combining robust qualities of the genetic algorithm with rapid machine learning.The approach is used to search for stable,compositionally variant,geometrically similar nanoparticle alloys to illustrate its capability for accelerated materials discovery,e.g.,nanoalloy catalysts.The machine learning accelerated approach,in this case,yields a 50-fold reduction in the number of required energy calculations compared to a traditional“brute force”genetic algorithm.This makes searching through the space of all homotops and compositions of a binary alloy particle in a given structure feasible,using density functional theory calculations. | Paul C.Jennings Steen Lysgaard Jens Strabo Hummelshøj Tejs Vegge Thomas Bligaard | 2019 | npj Computational Materials2019，，1： | 5 |
| 2 | Better to be alone than in bad company:The antagonistic effect of cisplatin and crizotinib combination therapy in non-small cell lung cancer显示文摘AIM To investigate the potential benefit of combining the cMET inhibitor crizotinib and cisplatin we performed in vitro combination studies.METHODS We tested three different treatment schemes in four non-small cell lung cancer(NSCLC) cell lines with a different cMET/epidermal growth factor receptor genetic background by means of the sulforhodamine B assay and performed analysis with Calcusyn.RESULTS All treatment schemes showed an antagonistic effect in all cell lines,independent of the cMET status.Despite their different genetic backgrounds,all cell lines(EBC-1,HCC827,H1975 and LUDLU-1) showed antagonistic combination indexes ranging from 1.3-2.7.These results were independent of the treatment schedule.CONCLUSION These results discourage further efforts to combine cMET inhibition with cisplatin chemotherapy in NSCLC. | Nele Van Der Steen Christophe Deben Vanessa Deschoolmeester An Wouters Filip Lardon Christian Rolfo Paul Germonpré Elisa Giovannetti Godefridus J Peters Patrick Pauwels | 2016 | World Journal of Clinical Oncology2016，7，6： | 2 |
| 3 | WJD 5^(th) Anniversary Special Issues(2): Type 2 diabetes Effects of exercise training on mitochondrial function in patients with type 2 diabetes显示文摘Type 2 diabetes is characterized by a decreased ability of insulin to facilitate glucose uptake into insulin sensitive tissue,i.e.,skeletal muscle.The mechanism behind this is at the moment unresolved.It has been suggested that increased amount of lipids inside the skeletal muscle(intramuscular triglyceride,diacylglycerol and ceramides)will impair insulin action in skeletal muscle,but data are not consistent in the human literature.It has also been hypothesized that the impaired insulin sensitivity is due to a dysfunction in the mitochondria resulting in an impaired ability to oxidize lipids,but the majority of the literature is not supporting this hypothesis.Recently it has been suggested that the production of reactive oxygen species play an essential role in skeletal muscle insulin sensitivity.It is well accepted that physical activity(endurance,strength and high intensity training)improves insulin sensitivity in healthy humans and in patients with type 2 diabetes.Whether patients with type 2 diabetes have the same beneficial effects(same improvement)as control subjects,when it comes to regular physical activity in regard to mitochondrial function,is not established in the literature.This review will focus only on the effect of physical activity on skeletal muscle(mitochondrial function)in patients with type 2 diabetes. | Steen Larsen Stinna Skaaby J rn W Helge Flemming Dela | 2014 | World Journal of Diabetes2014，5，4： | 2 |
| 4 | Pre-emptive analgesia显示文摘 | Jø rgen B. Dahl Steen Mø iniche | 2004 | British Medical Bulletin2004，，： | 2 |
| 5 | Levels of C-reactive Protein Are Associated With Response to Infliximab Therapy in Patients With Crohn’s Disease显示文摘 | Matthias Jürgens Jestinah M. Mahachie John Isabelle Cleynen Fabian Schnitzler Herma Fidder Wouter van Moerkercke Vera Ballet Maja Noman Ilse Hoffman Gert van Assche Paul J. Rutgeerts Kristel van Steen Severine Vermeire | 2011 | Clinical Gastroenterology and Hepatology2011，，5： | 2 |
| 6 | Evaluation and application of OSPM for traffic pollution assessment for a large number of street locations显示文摘 | BERKOWICZ R K ETZEL M STEEN S J | 2008 | Environmental Modelling & Software2008，23，3： | 1 |
| 7 | The mode of cell death induced by photodynamic treatment depends on cell density 显示文摘 | Dahle J Steen HB Moan J | 1999 | Photochem Photobiol1999，70，3： | 1 |
| 8 | Changes in the epidemiolngic profile of sudden infant death syndrome as rates decline among California infants:1990-1995显示文摘 | Adams E J Chavez G F Steen D | 1998 | Pediatrics1998，102，6： | 1 |
| 9 | Experiences from design and testing of waterjet inlets for high speed craft显示文摘 | Steen S Misaas K J | 1995 | FAST''951995，2，： | 1 |
| 10 | Recovery of selenium from copper anode slimes 显示文摘 | DUTTON W A van den STEEN A J THEMELIS N J | 1971 | Metallurgical Transactions1971，2，： | 1 |
| 11 | Harmonic analysis on tori显示文摘 | Palle E. T. J?rgensen Steen Pedersen | 1987 | Acta Applicandae Mathematicae1987，，1： | 1 |
| 12 | Oligonucleotide-priming methods for the chromosome-specific labelling of alpha satellite DNA in situ显示文摘 | J?rn E. Koch Steen K?lvraa Kirsten B. Petersen Niels Gregersen Lars Bolund | 1989 | Chromosoma1989，，4： | 1 |
| 13 | Use of the Barthel index and modi- fied Rankin Scaleim acute stroke scale in acute seroke trial 显示文摘 | Suher G Steen C De Keyser J | 1999 | Stroke1999，30，8： | 1 |
| 14 | Bioche~nistry and molec- ular biology of gelatinase B or matrix mmetalloproteninase-9 (MMP-9) : The next decade 显示文摘 | Vandooren J Van den Steen PE Opdenakker G | 2013 | Crit Rev Biochem Mol Bid2013，48，3： | 1 |
| 15 | Heat transfer model for Cw laser material processing显示文摘 | Mazumder J Steen W M | 1980 | Appl Phys1980，51，2： | 1 |
| 16 | A point and line source model of laser key hole welding显示文摘 | Steen W M Dowden J Davis M | 1988 | Journal of Physics D: Applied Physics1988，21，8： | 1 |
| 17 | Use of the Barthel index and modified Rankin scale in acute stroke trials显示文摘 | Sulter G Steen C de Keyser J | 1999 | Stroke1999，30，： | 1 |
| 18 | Review of the methods to determine the hazard and toxicity of pesticides to bumblebees显示文摘 | Van der Steen J J M | 2001 | Apidologie2001，32，： | 1 |
| 19 | Langmuir probe measurements in ex-panding magnetized argon?nitrogen and hydrogen plas-mas显示文摘 | BRUSSAARD G J H VAN DER STEEN M CAR-RERE M | 1998 | Surface and Coating Technology1998，98，13： | 1 |
| 20 | Monoclonal IgG antibodies generated from jolnt-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition 显示文摘 | Amara K Steen J Murray F | 2013 | The Journal of experimental medicine2013，210，3： | 1 |
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