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| 1 | The role of leptin/adiponectin ratio in metabolic syndrome and diabetes显示文摘 | Patricio López-Jaramillo Diego Gómez-Arbeláez Jose López-López Cristina López-López Javier Martínez-Ortega Andrea Gómez-Rodríguez Stefany Triana-Cubillos | 2014 | Hormone Molecular Biology and Clinical Investigation2014，，1： | 4 |
| 2 | Contactless inductive flow tomography for a model of continuous steel casting显示文摘 | T Wondrak V Galindo G Gerbeth T Gundrum F Stefani K Timmel | 2010 | Measurement Science and Technology2010，，4： | 3 |
| 3 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 4 | Dermoscopyin general dermatology 显示文摘 | Zalaudek I Argenziano G Di Stefani A | 2006 | Dermatology2006，212，1： | 1 |
| 5 | A methodology for minimum environmental impact analysis显示文摘 | PISTIKOPOULOS E N STEFANIS S K LIVINGSTON A G | 1994 | AICh E Symposium1994，90，303： | 1 |
| 6 | A methodology for environmental impact minimization:solvent design and reaction path synthesis issues显示文摘 | Stefanis S K Buxton A Livingston A G Pistikopoulos E N | 1996 | Computers & Chemical Engineering1996，20，： | 1 |
| 7 | The let-7 microrna represses cell proliferation pathways in human cells显示文摘 | Johnson CD Esquela-Kerscher A Stefani G | 2007 | Cancer Res2007，67，16： | 1 |
| 8 | Toward designing pillared clays for catalysis 显示文摘 | STEFANIS A TOMLINSON A A G | 2006 | Catal Today2006，114，： | 1 |
| 9 | Small non-coding RNAs in animal develop-ment显示文摘 | Stefani G Slack FJ | 2008 | Nat Rev Mol Cell Biol2008，9，3： | 1 |
| 10 | Retroperitoneal laparoendo- scopic single-site surgery:perliminary experience in kidney and u- reteral indications 显示文摘 | Micali S Isgr: G De Stefani S | 2011 | Eur Urel2011，59，1： | 1 |
| 11 | The let-7microRNA represses cell prolif-eration pathways in human cells显示文摘 | Johnson CD Esquela-Kerscher A Stefani G Byrom M Kelnar K Ovcharenko D | 2007 | Cancer Res2007，67，16： | 1 |
| 12 | Small non-coding RNAs in animal develop- ment显示文摘 | Stefani G Slack FJ | 2008 | Nat Rev Mol Cell Biol2008，9，3： | 1 |
| 13 | Role of hypoxia-inducible factor 1 ctin hypoxiainduced apoptosis of primary alveolar epithelial type Ⅱ cells显示文摘 | Stefanie K Bastian G E Jong H | 2005 | Am J Respir Cell Mol Biol2005，32，5： | 1 |
| 14 | DTC drives for wide speed range applications using a robust flux-weakening algorithm 显示文摘 | CASADEI D SERRA G STEFANI A | 2007 | IEEE Trans on Industrial Electronics2007，54，5： | 1 |
| 15 | The let-7 microRNA represses cell proliferation pathways in human cells显示文摘 | Johnson CD Esquela-Kerscher A Stefani G | | 0，，： | 1 |
| 16 | Small non-coding RNAs in animal development 显示文摘 | Stefani G Slack FJ | 2008 | Nat Rev/Viol Cell Biol2008，9，3： | 1 |
| 17 | Acute effects of physiological increments of brain natriuretic peptede in humans显示文摘 | Stefani L Lazzeri C | 1995 | Hypertension1995，26，： | 1 |
| 18 | Assessing the Eco-efficiency of End-of-Pipe Tech-nologies with the Environmental Cost Efficiency Indica-tor:A Case Study of Solid Waste Management显示文摘 | STEFANIE Hellweg GABOR Doka GRAN Finnve-den | 2005 | Jour-nal of Industrial Ecology2005，9，4： | 1 |
| 19 | Expression of cell cycle-related proteins in developiugand adult mouse hippocampus显示文摘 | Stefanie S Ulrich G Thomas A | 2005 | Int J Devl Neuro2005，23，8： | 1 |
| 20 | The let-7 microRNA represses cell proliferation pathways in human cells 显示文摘 | Johnson CD Esquela-Kerscher A Stefani G | 2007 | Cancer Res2007，67，16： | 1 |
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