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| 1 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 2 | Identifying the ‘unidentified’ fungi: a global-scale long-read third-generation sequencing approach显示文摘Molecular identification methods,in particular high-throughput sequencing tools,have greatly improved our knowledge about fungal diversity and biogeography,but many of the recovered taxa from natural environments cannot be identified to species or even higher taxonomic levels.This study addresses the phylogenetic placement of previously unrecognized fungal groups by using two complementary approaches:(i)third-generation amplicon sequencing analysis of DNA from global soil samples,screening out ITS reads of<90%similarity to other available Sanger sequences,and(ii)analysis of common fungal taxa that were previously indicated to be enigmatic in terms of taxonomic placement based on the ITS sequences alone(so-called top50 sequences).For the global soil samples,we chose to amplify the full rRNA gene operon using four partly overlapping amplicons and multiple newly developed primers or primer combinations that cover nearly all fungi and a vast majority of non-fungal eukaryotes.We extracted the rRNA 18S(SSU)and 28S(LSU)genes and performed phylogenetic analyses against carefully selected reference material.Both SSU and LSU analyses placed most soil sequences and top50 sequences to known orders and classes,but tens of monophyletic groups and single sequences remained outside described taxa.Furthermore,the LSU analyses recovered a few small groups of sequences that may potentially represent novel phyla.We conclude that rRNA genes-based phylogenetic analyses are efficient tools for determining phylogenetic relationships of fungal taxa that cannot be placed to any order or class using ITS sequences alone.However,in many instances,longer rRNA gene sequences and availability of both SSU and LSU reads are needed to improve taxonomic resolution.By leveraging third-generation sequencing from global soil samples,we successfully provided phylogenetic placement for many previously unidentified sequences and broadened our view on the fungal tree of life,with 10-20%new order-level taxa.In addition,the PacBio sequence data greatly extends fungal class-level information in reference databases. | Leho Tedersoo Sten Anslan Mohammad Bahram Urmas Kõljalg Kessy Abarenkov | 2020 | Fungal Diversity2020，，4： | 2 |
| 3 | Evaluation of the potential allergenicity of the enzyme microbial transglu-taminase using the 2001 FAO/WHO Decision Tree显示文摘 | Pedersen M H Hansen T K Sten E | 2004 | Molecular Nutritionc&Food Research2004，48，6： | 1 |
| 4 | Suramin interference with trans forming growth factor- (1 inhibition of human renal cell carcinoma in culture显示文摘 | Attan K Sten CA | 1992 | J Sug Res1992，53，19： | 1 |
| 5 | Primary habitualabortions are associated with high frequency of factor V Leiden mutation显示文摘 | Wramsby ML Sten LS Bremme K | 2000 | Fertil Teril2000，74，5： | 1 |
| 6 | Primary habitual abortions are associated with high frequency of Factor V Leiden mutation显示文摘 | Wramsby M L Sten L S Bremme K | 2000 | Fertil Steril2000，74，5： | 1 |
| 7 | Primary habitual abortions are associated with high frequency of Factor V Leiden mutation显示文摘 | Wramsby M L Sten L S Bremme K | 2000 | Fertil Steril2000，74，5： | 1 |
| 8 | Integration of plug-in hybrid electric vehicles in a regional wind-thermal power system显示文摘 | Lisa G Sten K Filip J | 2010 | Energy Policy2010，38，10： | 1 |
| 9 | Glucose and tolbutamide induce apoptosis in pancreatic-cells: a process dependent on intracellular Ca2+ concentration显示文摘 | Sergei VZ Boris Z Martin K Sten O Per-Olof B | 1998 | J Biol Chem1998，273，33： | 1 |
| 10 | collagen synthesis and types I, III, IV, lollagens in an animal model of disc degeneration显示文摘 | Eeva K Ziao Yan H Sten H | 1995 | spine1995，20，： | 1 |
| 11 | Primary habitual abortions are associated with high frequency of factor vleiden mutation显示文摘 | Wramsby ML Sten LS Bremme K | 2000 | Fertil Steril2000，74，5： | 1 |
| 12 | Chloride Extraction and Realkalization of Reinforced Concrete Stop Steel Corrosion 显示文摘 | EMMANUEL E VELIVASAKIS STEN K HENRIKSEN DAVID WHITMORE | 1998 | Journal of Performance of Constructed Facilities1998，12，2： | 1 |
| 13 | Primary habitual abor- tions are as sociated with high frequency of factory leiden mutation 显示文摘 | Wramsby ML Sten LS Bremme K | 2000 | Fertil Steril2000，74，5： | 1 |
| 14 | Protocols for DNA isolation and random amplified polymorphic DNA(RAPD) analysis on Sphagnum显示文摘 | Stenφien H K | 1999 | Lindbergia1999，24，： | 1 |
| 15 | A cognitive theory of graphical and 1inguistic reasoning::Logic and implementation显示文摘 | Stenning K Oberlande J | | 0，，： | 1 |
| 16 | Primary habitual abortions are ass-iated with high frequency of factory Leiden mutation显示文摘 | Wramsby ML Sten LS Bremme K | 2000 | Fertil Steril2000，74，5： | 1 |
| 17 | Success and spontaneous pregnancy rates following systemic methotrexate versus laparoscopic surgery for tubal pregnancies : a randomized trial 显示文摘 | LARS BO K M CHARLOTrE M STEN G T | 2009 | Acta Obstet Gynecol2009，88，： | 1 |
| 18 | Lycopenemhemistry,biology and implications for human health and disease显示文摘 | Sten K Clinton M D | 1998 | Nutrition Reviews1998，56，： | 1 |
| 19 | Primary habitual a- bortions are associated with high frequency of factor V Leiden mutation显示文摘 | Wramsby M L Sten L S Bremme K | 2000 | Fertil Steril2000，74，5： | 1 |
| 20 | Quality factor of an electrically small antenna radiating close to a conducting plane显示文摘 | STEN J C E HUJANEN A KOIVISTO P K | 2001 | IEEE Transactions on Antennas and Propagation2001，49，5： | 1 |
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