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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Corticotropin-releasing factor and urocortin 1 activate CREB through functionally selective G/ signalling in hippocampal pyramidal neurons显示文摘 | Stern C M Meitzen J Mermelstein P G | 2011 | Eur J Neurosci2011，34，5： | 1 |
| 3 | The Determinants of National Innovative Capacity显示文摘 | FURMAN J L PORTER M E STERN S | 2002 | Research Policy2002，31，8： | 1 |
| 4 | Subthalamic GAD gene transfer in Parkinson disease patients who are candidates for deep brain stimulation显示文摘 | During M J Kaplitt M G Stern M B | 2001 | Hum Gene Ther2001，12，12： | 1 |
| 5 | Mushrooms,Tumors, and Irnmunily 显示文摘 | Borchers A T Stern J S Hanckman R M | 1999 | Proceedings of the Society for Experimental Biology and Medicine1999，221，： | 1 |
| 6 | Mapping Gossans inArid Regions with Landsat TM and SIR-C Images:the BeddahoAlteration Zone in Northern Eritrea显示文摘 | Abdelsalam M G Stern R J Berhane W G | 2000 | Journal of African EarthSciences2000，30，4： | 1 |
| 7 | Cerebral infarction in young adults 显示文摘 | Kittner SJ Stern B J Wozniak M | 2004 | Neurology2004，50，9： | 1 |
| 8 | The determinants of national innovative capacity 显示文摘 | Furman J J Porter M E Stern S | 2002 | Research Policy2002，，31： | 1 |
| 9 | The determinants of national innovative capacity 显示文摘 | Furman J L Porter M E Stern S | 2002 | Research Policy2002，31，6： | 1 |
| 10 | The determinants of national innovative capacity 显示文摘 | FURMAN J PORTER M STERN S | 2002 | Research Policy2002，，3： | 1 |
| 11 | The determinants of national innovative capacity显示文摘 | Furman J Porter M Stern S | | 0，，31： | 1 |
| 12 | The determinants of national innovative capacity显示文摘 | FURMAN J L PORTER M E STERN S | 2002 | Research Policy2002，31，： | 1 |
| 13 | The determinants ofnational innovative capacily 显示文摘 | Furman J Porter M E Stern S etal | 2002 | Research Policy2002，1，31： | 1 |
| 14 | sympotomatic thoracic vertebral hemangioma:a case report and literature review显示文摘 | Rudniek J Stern M | | 0，，09： | 1 |
| 15 | The Determinants of National Inno- vative Capacity显示文摘 | Furman J L Porter M E Stern S | 2002 | Research Policy2002，31，6： | 1 |
| 16 | The determinants of national innovative capacity 显示文摘 | Furman J Porter M Stern S | 2002 | Research Policy2002，31，6： | 1 |
| 17 | Effect of initially limited resuscitation in a combined model of fluid - percussion brain injury and severe uncontrolled hemorrhagic shock 显示文摘 | Stern SA Zink B J Mertz M | 2013 | J Neurosurg2013，93，： | 1 |
| 18 | Happiness and time perspective as potential mediators of quality of life and depression in adolescent cancer显示文摘 | BITSKO M J STERN M DILLON R | 2008 | Pediatr Blood Cancer2008，50，3： | 1 |
| 19 | The determinants of national innovative capacity显示文摘 | Furman J L Porter M E Stern S | 2002 | Research Policy2002，31，： | 1 |
| 20 | Evaluation of a mathematical model of rnmen digestion and an in vitro simulation of rumen proteolysis to estimate the rumen- undegraded nitrogen content of feedstuffs显示文摘 | Krishnamoorthy U Sniffen C J Stern M D | 1983 | Brit J Nutr1983，50，3： | 1 |
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