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| 1 | Determinants of the impact of blood pressure variability on neurological outcome after acute ischaemic stroke显示文摘Introduction: Increased blood pressure variability (BPV) is detrimental after acute ischaemic stroke, but the interaction between BPV and neuroimaging factors that directly influence stroke outcome has not been explored. Methods: We retrospectively reviewed inpatients from 2007 to 2014 with acute anterior circulation ischaemic stroke, CT perfusion and angiography at hospital admission, and a modified Rankin Scale (MRS) 30- 365 days after stroke onset. BPV indices included SD, coefficient of variation and successive variation of the systolic blood pressure between 0 and 120 hours after admission. Ordinal logistic regression models were fitted to MRS with predictor variables of BPV indices. Models were further stratified by CT perfusion volumetric measurements, proximal vessel occlusion and collateral score. Results: 110 patients met the inclusion criteria. The likelihood of a 1-point rise in the MRS increased with every 10 mm Hg increase in BPV (OR for the 3 BPV indices ranged from 2.27 to 5.54), which was more pronounced in patients with larger ischaemic core volumes (OR 8.37 to 18.0) and larger hypoperfused volumes (OR 6.02 to 15.4). This association also held true for patients with larger mismatch volume, proximal vessel occlusion and good collateral vessels. Conclusions: These results indicate that increased BPV is associated with worse neurological outcome after stroke, particularly in patients with a large lesion core volume, concurrent viable ischaemic penumbra, proximal vessel occlusion and good collaterals. This subset of patients, who are often not candidates for or fail acute stroke therapies such as intravenous tissue plasminogen activator or endovascular thrombectomy, may benefit from interventions aimed at reducing BPV. | Adam de Havenon Alicia Bennett Gregory J Stoddard Gordon Smith Lee Chung Steve O’Donnell J Scott McNally David Tirschwell Jennifer J Majersik | 2017 | Stroke & Vascular Neurology2017，2，1： | 6 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Regional scale evidence for improvements in surface water chemistry 1990-- 2001显示文摘 | Skjelkvale B L Stoddard J L Jeffries D S | 2005 | Environmental Pollu- tion2005，137，： | 1 |
| 4 | Cu+- and Cu2x-sensitive PEBBLE fluorescent nanosensors u- sing DsRed as the recognition element 显示文摘 | Sumner J P Westerberg N M Stoddard A K | 2006 | Sens Actuators B2006，113，： | 1 |
| 5 | EMAP-surface water:a multi-assemblage probability survey of ecological integrity in the USA显示文摘 | Hughes R M Paulsen S G Stoddard J L | 2000 | Hydrobiologia2000，422，4： | 1 |
| 6 | A permanent-mag- net tubular linear generator for ocean wave energy conversion显示文摘 | PRUDELL J STODDARD M AMON E | 2010 | IEEE Transactions on Industry Applications2010，46，11： | 1 |
| 7 | A permanent-magnet tubular linear generator for ocean wave energy conversion industry applications显示文摘 | PRUDELL J STODDARD M AMON E | | 0，，06： | 1 |
| 8 | An analysis of conical scan antennas for tracking显示文摘 | DAMONTE J B STODDARD D J | 1956 | IRE National Convention Record1956，，4： | 1 |
| 9 | Attention bias to threat faces in severe mood dysregulation显示文摘 | Hommer R E Meyer A Stoddard J | 2014 | Depression and Anxiety2014，31，7： | 1 |
| 10 | Effect of prepartum dry matter intake on liver triglyceride coneentration in early lactation显示文摘 | Bertics S J Gmmmer R R Valino C C Stoddard E E | 1992 | J Dairy Sci1992，75，： | 1 |
| 11 | LPA receptor sig- naling: pharmacology, physiology, and pathophysiology 显示文摘 | YUNG Y C STODDARD N C CHUN J | 2014 | J Lipid Res2014，55，7： | 1 |
| 12 | Setting expectations for the ecological condition of streams:the concept of reference condition显示文摘 | STODDARD J L LARSEN D P HAWKINS C P | | 0，，04： | 1 |
| 13 | Lupin flours asadditives: dough mixing, breadmaking, emulsifying, andfoaming 显示文摘 | Pollard N J Stoddard F L Popineau Y | 2002 | Cereal chemistry2002，79，5： | 1 |
| 14 | Oxidative inhibition of human soluble catechol-O-methyltransferase显示文摘 | COTTON N J STODDARD B PARSON W W | 2004 | J Biol Chem2004，279，23： | 1 |
| 15 | An analysis of conical scan an- tennas for tracking 显示文摘 | DAMONTE J B STODDARD D J | 1956 | IRE National Convention Record1956，，4： | 1 |
| 16 | Selection and characterization of cyanophage resistance in marine Synechococcus strains 显示文摘 | Stoddard L I Martiny J B Marston M F | 2007 | Applied and Environmental Microbiology2007，73，： | 1 |
| 17 | Prefrontal glucose deficits in murderers lacking psychosocial deprivation显示文摘 | Phil D Stoddard J | 1998 | Neuropsychiatry Neuropsychol Behav Neurol1998，11，1： | 1 |
| 18 | Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production显示文摘 | Bert K Lopansri Nicholas M Anstey J Brice Weinberg Gregory J Stoddard Maurine R Hobbs Marc C Levesque Esther D Mwaikambo Donald L Granger | 2003 | The Lancet2003，，9358： | 1 |
| 19 | The Association Between Socioeconomic Status, Health Insurance Coverage, and Quality of Life Inmenwith Prostrate Cancer显示文摘 | Penson D F M L Stoddard D J Pasta D P Lubeck S C Flanders M S Litwin | 2001 | Journal of Clinical Epidemiology2001，54，4： | 1 |
| 20 | A process\sfor creating multimetric indices for large-scale aquatic\ssurveys显示文摘 | Stoddard J L Herlihy A T Peck D V | 2008 | Journal of the North American Benthological Society2008，27，4： | 1 |
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