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| 1 | Human enamel thickness and ENAM polymorphism显示文摘The tooth enamel development gene, enamelin(ENAM), showed evidence of positive selection during a genome-wide scan of human and primate DNA for signs of adaptive evolution. The current study examined the hypothesis that a single-nucleotide polymorphism(SNP) C14625T(rs7671281) in the ENAM gene identified in the genome-wide scan is associated with a change in enamel phenotype. African Americans were selected as the target population, as they have been reported to have a target SNP frequency of approximately 50%, whereas non-Africans are predicted to have a 96% SNP frequency. Digital radiographs and DNA samples from 244 teeth in 133 subjects were analysed, and enamel thickness was assessed in relation to SNP status,controlling for age, sex, tooth number and crown length. Crown length was found to increase with molar number, and females were found to have thicker enamel. Teeth with larger crowns also had thicker enamel, and older subjects had thinner enamel.Linear regression and generalized estimating equations were used to investigate the relationship between enamel thickness of the mandibular molars and ENAM SNP status; enamel in subjects with the derived allele was significantly thinner(P = 0.040)when the results were controlled for sex, age, tooth number and crown length. The derived allele demonstrated a recessive effect on the phenotype. The data indicate that thinner dental enamel is associated with the derived ENAM genotype. This is the first direct evidence of a dental gene implicated in human adaptive evolution as having a phenotypic effect on an oral structure. | Diane M Daubert Joanna L Kelley Yuriy G Udod Carolina Habor Chris G Kleist Ilona K Furman Igor N Tikonov Willie J Swanson Frank A Roberts | 2016 | International Journal of Oral Science2016，8，2： | 2 |
| 2 | The clinical utility of flexible bronchoscopy in the evaluation of chronic cough显示文摘 | Barnes T W Afessa B Swanson K L | 2004 | Chest2004，126，1： | 2 |
| 3 | Differential meiospore size and tolerance of ultraviolet light stress within and among kelp species along a depth gradient 显示文摘 | Swanson A K Druehl L D | 2000 | Mar Biol2000，136，4： | 1 |
| 4 | Methionine sulfoximine reduces cortical infarct size in rats after middle cerebral artery occlusion显示文摘 | Swanson R A Shiraishi K Morton MT | 1990 | Stroke1990，21，2： | 1 |
| 5 | A classification for cougeuital limb malformation 显示文摘 | Swanson AB Swanson GD Tada K | 1983 | J Hamt Surg Am1983，8，52： | 1 |
| 6 | Epigenetic regulation of milk production in dairy cows显示文摘 | Singh K Erdman R A Swanson K M | 2010 | Journal of Mammary Gland Biology and Neoplasia2010，15，1： | 1 |
| 7 | A classification for congenital limb malformation显示文摘 | Swanson AB Swanson GD Tada K | 1983 | J Hand Surg Am1983，8，52： | 1 |
| 8 | Coordination, challenges, and innovations in 19 national sustainable development strategies 显示文摘 | Volkery A Swanson D Jacob K | 2006 | World Development2006，34，12： | 1 |
| 9 | Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans显示文摘 | TINSLEY K W SWANSON P E | 2001 | J Immunol2001，166，11： | 1 |
| 10 | Influence of undegraded intake protein on retake,digestion,serum hormones and metabolites,and nitrogen balance in sheep显示文摘 | Swanson K C Catun J S Redmer D A | 2000 | Small Ruminant Reserch2000，35，： | 1 |
| 11 | Dermatofibrosarcoma protuberans:a partial response to imatinib therapy显示文摘 | Mehrany K Swanson NA Heinrich MC | 2006 | Dermatol Surg2006，32，3： | 1 |
| 12 | Evidence forpreferential flow through sandstone aquifers in Southern Wisconsin显示文摘 | SWANSON S K BAHR J M BRADBURY K R | 2006 | Sedimentary Geology2006，184，33： | 1 |
| 13 | Oncological efficacy and safety of nephron- sparing surgery for selected patients with locally ad- vanced renal cell carcinoma显示文摘 | Margulis V Tamboli P Jaeobsohn K M Swanson D A Wood C G | 2007 | BJU Int2007，100，： | 1 |
| 14 | Ecology of coarse woody debris in temperate ecosystems 显示文摘 | Harmon ME Anderson NH Franklin JF Cline SP Swanson JF Aumen NG Solins P Sedell JR Gregpry SV Lienkaemper GW Lattin J D Cromack K Cummins KW | 1986 | Adv Ecol Res1986，15，： | 1 |
| 15 | Effect of Crystal Orientation on Fatigue of Single Crystal Nickel Base Turbine Blade Superalloys 显示文摘 | Swanson G | 2002 | Journal of Engineering for Gas Turbines and Power2002，124，： | 1 |
| 16 | Storm track dynamic显示文摘 | Chang E K Lee M S Swanson K L | 2002 | J Climate2002，15，16： | 1 |
| 17 | Influence of undegraded intake protein on intake,digestion,serum hormones and metabolites,and nitrogen balance in sheep显示文摘 | Swanson K C Caton J S Redmer D A | 2000 | Small Rumin Res2000，35，： | 1 |
| 18 | Effect of Crystal Orientation on Fatigue Failure of Single Crystal Nickel Base Turbine Blade Superalloys显示文摘 | Arakere N K Swanson G | 2002 | ASME Journal of Engineering for Gas Turbines and Power2002，124，1： | 1 |
| 19 | Expression of a beta-defensin mRNA,lingual antimicrobial peptide,in bovine mammary epithelial tissue is induced by mastitis显示文摘 | Swanson K Gorodetsky S Good L | 2004 | Infect Immun2004，72，12： | 1 |
| 20 | Endothelial cell apoptosis in sepsis显示文摘 | Hotchkiss R S Tinsley K W Swanson P E | 2002 | Crit Care Med2002，30，5： | 1 |
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