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| 1 | Neutrophil-lymphocyte ratio:A prognostic tool in patients with inhospital cardiac arrest显示文摘BACKGROUND In-hospital cardiac arrest(IHCA) portends a poor prognosis and survival to discharge rate. Prognostic markers such as interleukin-6, S-100 protein and high sensitivity C reactive protein have been studied as predictors of adverse outcomes after return of spontaneous circulation(ROSC); however; these variables are not routine laboratory tests and incur additional cost making them difficult to incorporate and less attractive in assessing patient's prognosis. The neutrophil-lymphocyte ratio(NLR) is a marker of adverse prognosis for many cardiovascular conditions and certain types of cancers and sepsis. We hypothesize that an elevated NLR is associated with poor outcomes including mortality at discharge in patients with IHCA.AIM To determine the prognostic significance of NLR in patients suffering IHCA who achieve ROSC.METHODS A retrospective study was performed on all patients who had IHCA with the advanced cardiac life support protocol administered in a large urban community United States hospital over a one-year period. Patients were divided into two groups based on their NLR value(NLR < 4.5 or NLR ≥ 4.5). This cutpoint was derived from receiving operator characteristic curve analysis(area under the curve = 0.66) and provided 73% positive predictive value, 82% sensitivity and42% specificity for predicting in-hospital death after IHCA. The primary outcome was death or discharge at 30 d, whichever came first.RESULTS We reviewed 153 patients with a mean age of 66.1 ± 16.3 years; 48% were female.In-hospital mortality occurred in 65%. The median NLR in survivors was 4.9(range 0.6-46.5) compared with 8.9(0.28-96) in non-survivors(P = 0.001). A multivariable logistic regression model demonstrated that an NLR above 4.55[odds ratio(OR) = 5.20, confidence interval(CI): 1.5-18.3, P = 0.01], older age(OR= 1.03, CI: 1.00-1.07, P = 0.05), and elevated serum lactate level(OR = 1.20, CI:1.03-1.40, P = 0.02) were independent predictors of death.CONCLUSION An NLR ≥ 4.5 may be a useful marker of increased risk of death in patients with IHCA. | Vishal H Patel Philip Vendittelli Rajat Garg Susan Szpunar Thomas LaLonde John Lee Howard Rosman Rajendra H Mehta Hussein Othman | 2019 | World Journal of Critical Care Medicine2019，8，2： | 5 |
| 2 | Bioinspired and hydrophobic alkyl-silanized protective polymer coating for Mg alloy显示文摘The modification of silica coating surfaces by trimethylsilylation has contributed to enhanced hydrophobicity(θ_w^o>90°)against fluid permeation and corrosion in Na Cl.These alkyl-silanized coatings were deployed to protect Mg alloy after reinforcing their internal structures with nanosilica powder.The reduced wetness of coating surfaces is attributed to their chemically-modified surface morphology,and this has been compared to the reticulate leaf structures of lotus plant.The optimum amount of silylating additive(hexamethyldisilazane)required to prepare a hydrophobic coating with minimum water adhesion has been established.Barrier performance of coatings were examined by electrochemical and surface analyses in 5 wt%Na Cl.The corrosion resistance of these coatings is a result of the direct contribution of their bulk stability and surface hydrophobicity,and this is expressed in terms of the variation of electrochemical parameters with exposure time.These coatings may have emerging industrial applications,including a future in metal surface treatments and anticorrosion paints. | Ubong Eduok Jerzy Szpunar | 2018 | Progress in Natural Science:Materials International2018，28，3： | 2 |
| 3 | Texture development during grain growth in non-oriented electrical steels 显示文摘 | Park J T Szpunar J A | 2005 | IS[J International2005，45，5： | 1 |
| 4 | Memory for Emotional Simulations Remembering a rosy Future显示文摘 | Szpunar KK Addis DR Schacter DL | 2012 | Psychological Science2012，，23： | 1 |
| 5 | Evolution of Recrystallization Texturein Non Oriented Electrical Steels 显示文摘 | Park J T Szpunar J A | 2003 | Acta Materialia2003，51，11： | 1 |
| 6 | The Role of Grain Boundary Character Distribution in Secondary Recrystallization Electrical Steels显示文摘 | Hayakawa Y Szpunar J A | 1997 | Acta Mater1997，45，3： | 1 |
| 7 | Evidence for an implicit influence of memory on future thinking显示文摘 | Szpunar KK Karl K | 2010 | Memory & Cognition2010，38，5： | 1 |
| 8 | A New Model of Goss Texture Development during Secondary Recrystallization of Electrical Steel显示文摘 | Hayakawa Y Szpunar J A | 1997 | Acta Mater1997，45，11： | 1 |
| 9 | β-Adrenergic receptors(β-AR)regulate VEGF and IL-6 production by divergent pathways in high β-AR-expressing breast cancer cell lines显示文摘 | Madden KS Szpunar MJ Brown EB | | 0，，03： | 1 |
| 10 | Effectofinitialgrainsizeontextureevolutionandmagneticpropertiesinnon-orientedelectricalsteels显示文摘 | Jong-TaePark JerzyA Szpunar | 2009 | JournalofMagnetismandMagneticMaterials2009，，321： | 1 |
| 11 | The nanocrystalline ceria sol-gel coatings for high temperature applications 显示文摘 | CZERWINSKI F SZPUNAR J A | 1997 | Journal of Sol-Gel Science and Technology1997，9，1： | 1 |
| 12 | 显示文摘 | Joanna Szpunar Ryszard ?obiński | 2002 | Analytical and Bioanalytical Chemistry2002，，6： | 1 |
| 13 | Characterization of the microstructure and texture of functionally graded nickel-AlzO3 nano composite coating produced by pulse deposition 显示文摘 | LAJEVARD S A SHAHRABI T SZPUNAR J A | 2013 | Surface & Coatings Technology2013，232，： | 1 |
| 14 | Stored energy and Taylor factor relation in an A1-Mg-Mn alloy sheet worked by continuous cyclic bending显示文摘 | TAKAYAMA Y SZPUNAR J A | 2004 | Mater Trans2004，45，： | 1 |
| 15 | Characterization of arsenic species in kidney of the clam Tridacna derasa by multidimensional liquid chromatography- ICPMS and electrospray time-of-Xight tandem mass spectrometry 显示文摘 | Mcsheehy S Szpunar J Lobinski R etal | 2002 | Anal Chem2002，74，： | 1 |
| 16 | Wear and corro- sion wear of medium carbon steel and 304 stainless steel 显示文摘 | Reza B M Szpunar J A Wang X | 2006 | Wear2006，260，12： | 1 |
| 17 | Speciation in the environmental field-trends in analytical chemistry 显示文摘 | SZPUNAR J LOBINSKI R | 1999 | Fresenius Journal of Analytical Chemistry1999，363，5： | 1 |
| 18 | Improving the tribological behavior of copper through novel Ti-Cu intermetallic coatings显示文摘 | BATENI M R ASHRAFIZADEH F SZPUNAR J A DREW R A L | 2002 | Wear2002，253，56： | 1 |
| 19 | An observation of palladium membrane formation on a porous stainless steel substrate by electroless deposition显示文摘 | Shi Z L Wu S Q Szpunar J A | 2006 | J Membrane Sci2006，280，： | 1 |
| 20 | Texture and magnetic properties in Fe-Si steel显示文摘 | J. Szpunar M. Ojanen | 1975 | Metallurgical Transactions A1975，，2： | 1 |
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