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| 1 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 2 | 2型糖尿病合并高血压患者维生素D缺乏的高患病率及其与胱抑素C和其他心血管病及肾脏风险生物标志物的相关性显示文摘越来越多人研究维生素D在2型糖尿病(type 2diabetes,T2DM)及其心血管病和肾脏病并发症中的作用。本研究旨在调查25-羟基维生素D[25-hydroxyvitamin D,25(OH)D]与心血管病和肾脏病并发症的生物标志物之间的关系,包括胱抑素C。方法:本项横断面研究涉及T2DM患者117例,他们除高血压外没有心血管病或肾脏疾病。采用电化学发光免疫法测定25(OH)D,采用酶联免疫吸附法测定血清胱抑素C。用常规生物化学法测定其他生物标志物,包括脂质、肌酐、尿素和血糖。结果:维生素D缺乏患病率为74.36%。缺乏和不缺乏维生素D的参与者心血管病和肾脏病生物标志物差异无统计学意义。 | Alkhatatbeh MJ Smadi SA Abdul-Razzak KK Saadeh NA 陈嘉睿(译) 叶鹏(审校) | 2021 | 中华高血压杂志2021，29，5： | 2 |
| 3 | Local and distant histopathological effects of unilateral amyloid beta25-35 injections into the amygdala of young F344 rats显示文摘 | Sigurdsson EM Lorens SA Hejna MJ | 1996 | Neurobiol Aging1996，17，6： | 1 |
| 4 | Serological survey of giant pandas(Ailuropoda melanoleuca),and domestic dogs and cats in Wolong Reserve,China显示文摘 | Q Xianmeng H Tingmei and MJ Appel | 1994 | J Wildl Dis1994，30，： | 1 |
| 5 | Smoking and smoking cessation in relation to mortality in women显示文摘 | Kenfield SA Stampfer MJ Rosner BA | 2008 | JAMA2008，299，17： | 1 |
| 6 | Bikunin (urinary trypsin inhibitor):structure,biological relevance,and measurement显示文摘 | Pugia MJ Valdes R Jr Jortani SA | | 0，，： | 1 |
| 7 | Prevalence of lymphedema in women with breast cancer 5 years after sentinel lymph node biopsy or axillary dissection:objective measurements显示文摘 | McLaughlin SA Wright MJ Morris KT | | 0，，32： | 1 |
| 8 | The epithelial-mesenchymal transition generates cells with properties of stem cells显示文摘 | Mani SA Guo W Liao MJ | 2008 | Cell2008，133，4： | 1 |
| 9 | The epithelial-mesenchymal transition generates cells with properties of stem cells显示文摘 | Mani SA Guo W Liao MJ | 2008 | Cell2008，133，4： | 1 |
| 10 | Prevalence of lymphedema in women with breast cancer 5 years after sentinel lymph node biopsy or axillary dissection,objective measurements显示文摘 | MCLAUGHLIN SA WRIGHT MJ MORRIS KT | 2008 | J Clin Oncol2008，26，32： | 1 |
| 11 | Risk factors for lymphedema after breast cancer treatment 显示文摘 | Norman SA Localio AR Kallan MJ | 2010 | Cancer Epidemiol Biomarkers Prey2010，19，11： | 1 |
| 12 | The safety profiles of orlistat and sibutramine: results of prescription-event monitoring studies in England显示文摘 | Perrio MJ Wilton LV Shakir SA | 2007 | Obesity2007，15，11： | 1 |
| 13 | Capillary bridg- es between two spherical bodies 显示文摘 | Willett CD Adams MJ Johnson SA | 2000 | Langmuir2000，16，24： | 1 |
| 14 | Risk factors for lymphedema after breast cancer treatment 显示文摘 | Norman SA Localio RA Kallan MJ | 2010 | Cancer Epidemiol Biomarkers Prey2010，19，11： | 1 |
| 15 | Multiplex PCR for detection of aminoglycoside resistance genes in enterococci 显示文摘 | Chow JW Lemer SA Zervos MJ | 2003 | Antimicrob Agents Chemother2003，47，： | 1 |
| 16 | Estrogen therapy influence onpefiurethral vessels in postmenopausal ineontinence women using Dopplerveloeimetry analysis 显示文摘 | Kobata SA Girao MJ Baracat EC | 2011 | Maturitas2011，61，3： | 1 |
| 17 | Statins prevent dex- trose-induced endothelial barrier dysfunction, possibly through inhi- bition of superoxide formation 显示文摘 | Haas MJ Horani MH Parseghian SA | 2006 | Diabetes2006，55，2： | 1 |
| 18 | Validation of optical low coherence reflectometry retinal and choroidal biometry显示文摘 | Read SA Colllins MJ Alonso-Caneiro D | 2011 | Optom Vis Sci2011，88，7： | 1 |
| 19 | The epithelial-mesenchymal transition generates cells with properties of stem cells显示文摘 | Mani SA Guo W Liao MJ | 2008 | Cell2008，133，4： | 1 |
| 20 | Atypical fibroxanthoma with prominent scoerosis显示文摘 | Medlicott SA Trotter MJ | 2003 | J Cutan Pathol2003，30，5： | 1 |
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