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| 1 | CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells显示文摘AIM:The effects of vitamin D3 have been investigated on various tumors, including colorectal cancer (CRC). 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered to be the main enzyme determining the biological halflife of 1,25-D3. During colorectal carcinogenesis, the expression and concentration of CYP24A1 increases significantly, suggesting that this phenomenon could be responsible for the proposed efficacy of 1,25-D3 in the treatment of CRC. The aim of this study was to investigate the anti-tumor effects of vitamin D3 on the human CRC cell line Caco-2 after inhibition of the cytochrome P450 component of CYP24A1 activity. METHODS:We examined the expression of CYP24A1 mRNA and the effects of 1,25-D3 on the cell line Caco-2 after inhibition of CYP24A1. Cell viability and proliferation were determined by means of sulforhodamine-B staining and bromodeoxyuridine incorporation, respectively, while cytotoxicity was estimated via the lactate dehydrogenase content of the cell culture supernatant. CYP24A1 expression was measured by realtime reverse transcription polymerase chain reaction. A number of tetralone compounds were synthesized to investigate their CP24A1 inhibitory activity. RESULTS:In response to 1,25-D3, CYP24A1 mRNA expression was enhanced significantly, in a time- and dose-dependent manner. Caco-2 cell viability and proliferation were not influenced by the administration of 1,25-D3 alone, but were markedly reduced by coadministration of 1,25-D3 and KD-35, a CYP24A1-inhibiting tetralone. Our data suggest that the mechanism of action of co-administered KD-35 and 1,25-D3 does not involve a direct cytotoxic effect, but rather the inhibition of cell proliferation. CONCLUSION:These findings demonstrate that the selective inhibition of CYP24A1 by compounds such as KD-35 may be a new approach for enhancement of the anti-tumor effect of 1,25-D3 on CRC. | János P Kósa Péter Horváth János Wlfling Dóra Kovács Bernadett Balla Péter Mátyus Evelin Horváth Gábor Speer István Takács Zsolt Nagy Henrik Horváth Péter Lakatos | 2013 | World Journal of Gastroenterology2013，19，17： | 5 |
| 2 | The first pterosaur 3-D egg:Implications for Pterodaustro guinazui nesting strategies,an Albian filter feeder pterosaur from central Argentina显示文摘The increasing number of fossil pterosaur eggs sheds light on nesting environments and breeding behaviors of these extinct flying reptiles.Here we report the first partial three-dimensional egg of the pterosaur,Pterodaustro guinazui,from central Argentina.The specimen was discovered from the same Albian deposits as the exceptional P.guinazui embryo described in 2004.Microscopic characterizations indicate a pristine preservation of the 50 mm thick calcium carbonate,which differs significantly from the soft shell of Chinese pterosaur eggs.Estimate of the eggshell conductance implies that the nest had a minimum moisture content of 75%.This moisture estimate,combined with geological and taphonomical data,suggests that P.guinazui may have adopted a nesting strategy similar to those of grebes and flamingos rather than being buried on land,as previously hypothesized.Moreover,our results demonstrate that the nesting paleoenvironment of this pterosaur species was closely linked to a mesohaline lacustrine ecosystem in a basin governed by regional tectonic subsidence,a setting characteristic for the feeding and reproduction of modern flamingos. | Gerald Grellet-Tinner Michael B.Thompson Lucas E.Fiorelli Eloísa Argaaraz Laura Codorniú E.Martín Hechenleitner | 2014 | Geoscience Frontiers2014，5，6： | 2 |
| 3 | 视网膜病变、视网膜微血管异常与脑卒中、脑血管病的关系显示文摘视网膜循环异常可能与脑血管病有关。该研究基于英国的三民族人口的基础队列调查了视网膜微血管异常与脑卒中和亚临床脑梗死及脑白质病变之间的相关性。方法:纳入1185名受试者[年龄(68.8±6.1)岁,77%为男性]进行视网膜成像和脑磁共振成像。利用磁共振成像识别脑梗死和脑白质高信号,对视网膜病变进行分级,并测量视网膜血管参数。 | 刘莉 叶鹏 Hughes AD Falaschetti E Witt N Wijetunge S Thom SA Tillin T Aldington SJ Chaturvedi N | 2016 | 中华高血压杂志2016，24，11： | 2 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 6 | 血管生成素样蛋白2水平与肾移植术后主动脉僵硬度和死亡率呈正相关显示文摘血管生成素样蛋白2(angiopoietin-like-2,ANGPTL2)是一种分泌性糖蛋白,可诱发血管内皮功能障碍、动脉粥样硬化和心血管病。循环ANGPTL2在慢性肾脏病(chronic kidney disease,CKD)患者中增加,加重患心血管病的风险。 | Desjardins MP Thorin-Trescases N Sidibé A Fortier C DeSerres SA Larivière R Thorin E Agharazii M 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 7 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 8 | Spontaneous intracranial hypotension显示文摘 | Renowden SA Gregory R Hyman N | 1995 | J Neurol Neurosurg Psychiatry1995，59，5： | 2 |
| 9 | The interplay of osteogenesis and hematopoiesis: expression of a constitutively active PTH/PTHrP receptor in osteogenic cells perturbs the establishment of hematopoiesis in bone and of skeletal stem cells in the bone marrow显示文摘 | KUZNETSOV SA RIMINUCCI M ZIRAN N | 2004 | J Cell Biol2004，167，6： | 1 |
| 10 | Cerebral corti- cal dysfunction in chronic obstructive pulmonary disease: role of transcranial magnetic stimulation显示文摘 | Mohamed-Hussein AA Hamed SA Abdel-Hakim N | 2007 | Int J Tuberc Lung Dis2007，11，5： | 1 |
| 11 | Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis显示文摘 | DAUGAS E SUSIN SA ZAMZAMI N | 2000 | FASEB J2000，14，： | 1 |
| 12 | Mitochondrial control of apoptosis显示文摘 | Kroemer G Zamzami N Susin SA | 1997 | Immunol Today1997，18，： | 1 |
| 13 | Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death显示文摘 | Joza N Susin SA Daugas E | 2001 | Nature2001，410，6828： | 1 |
| 14 | Myocardial injury and left ventricular performance after subarachnoid hemorrhage 显示文摘 | Mayer SA Lin J Homma N | 1999 | Stroke1999，30，4： | 1 |
| 15 | Rising trends in cholangiocarcinoma: is the ICD classification system misleading us? 显示文摘 | Khan SA Emadossadaty S Ladep N | 2012 | J Hepatol2012，56，4： | 1 |
| 16 | Oligosaccharide side chains on human secretory IgA serve as receptors for ricin 显示文摘 | Mantis N J Farrant SA Mehta S | 2004 | J Immunol2004，172，11： | 1 |
| 17 | Isolation of three high molecular weight polysaccharide preparations with potent immunostimulatory activity from Spirulina platensis apha- aizomenon flos-aquae and Chlorella pyrenoidosa 显示文摘 | Paugh N Ross SA EISohly HN | 2001 | Planta Med2001，67，8： | 1 |
| 18 | Hepatic-associated immunoglobulin-A nephropathy in a child with liver cirrhosis and portal hypertension显示文摘 | Alghamdi SA Saadah 0I Almatury N | | 0，，03： | 1 |
| 19 | CYP2E1 polymorphism,cigarette smoking,p53 expression,and survival in non-small cell lung cancer: a long term follow-up study显示文摘 | Haque AK Au W Ca j a s -Sa l a z a r N e t al | 2004 | Appl Immunohistochem Mol Morphol2004，12，4： | 1 |
| 20 | Volumetric mod- ulated arc radiotherapy for esophageal cancer显示文摘 | Vivekanandan N Sriram P Kumar SA | 2012 | Med Dosim2012，37，1： | 1 |
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