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| 1 | 血管性认知障碍的诊断标准:国际血管性行为与认知障碍学会的申明显示文摘长期以来,脑血管病(CVD)就被认为是认知损害的一个重要原因,但是有关脑血管病后认知障碍的概念化却有着一段多变的历史。'动脉变硬'或脑的动脉粥样硬化是'老化'的原因,是存在已久的观点,在20世纪60年代受到了来自英格兰纽卡斯尔的神经病理学研究的质疑。这些研究表明,血管性痴呆(vascular dementia,Va D)与超过一定程度的多发性脑梗死有关。 | 徐岩 郭起浩 Sachdev P Kalaria R O'Brien J Skoog I Alladi S Black SE Blacker D Blazer DG Chen C Chui H Ganguli M Jellinger K Jeste DV Pasquier F Paulsen J Prins N Rockwood K Roman G Scheltens P | 2014 | 神经病学与神经康复学杂志2014，11，3： | 19 |
| 2 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 3 | Prevalence and virological profiles of hepatitis B infection in human immunodeficiency virus patients显示文摘AIM: To determine the prevalence of hepatitis B virus (HBV) in adult human immunodeficiency virus (HIV) patients with CD4+ T-cell count less than 500/mm 3 and without antiretroviral therapy; to describe different HBV-HIV coinfection virological profiles; and to search for factors associated with HBs antigen (HBsAg) presence in these HIV positive patients.METHODS: During four months (June through September 2006), 491 patients were received in four HIV positive monitoring clinical centers in Abidjan. Inclusion criteria: HIV-1 or HIV-1 and 2 positive patients, age ≥ 18 years, CD4+ T-cell count < 500/mL and formal and signed consent of the patient. Realized blood tests included HIV serology, CD4+ T-cell count, quantitative HIV RNA load and HBV serological markers, such as HBsAg and HBc antibody (anti-HBcAb). We performed HBeAg, anti-HBe antibody (anti-HBeAb), anti-HBc IgM and quantitative HBV DNA load in HBsAg positive patients. Anti-HBsAb had been tested in HIV patients with HBsAg negative and anti-HBcAb-positive. HBV DNA was also tested in 188 anti-HBcAb positive patients with HBsAg negative status and without anti-HBsAb. Univariate analysis (Pearsonχ 2 test or Fischer exact test) and multivariate analysis (backward step-wise selection logistic regression) were performed as statistical analysis. RESULTS: Mean age of 491 patients was 36 ± 8.68 years and 73.3% were female. Type-1 HIV was found in 97% and dual-type HIV (type 1 plus type 2) in 3%. World Health Organization (WHO) clinical stage was 1, 2, 3 and 4 respectively in 61 (12.4%), 233 (47.5%), 172 (35%) and 25 patients (5.1%). Median CD4+ T-cell count was 341/mm 3 (interquartile range: 221-470). One hundred and twelve patients had less than 200 CD4+ T-cell/mm 3 . Plasma HIV-1 RNA load was elevated (≥ 5 log 10 copies/mL) in 221 patients (45%). HBsAg and anti-HBcAb prevalence was respectively 13.4% and 72.9%. Of the 66 HBsAg positive patients, 22 were inactive HBV carriers (33.3%), 21 had HBeAg positive hepatitis (31.8%) and 20 had HBeAg negative hepatitis (30.3%). HBeAg and anti-HBeAb were indeterminate in 3 of them. Occult B infection prevalence (HBsAg negative, anti-HBcAb positive, anti-HBsAb negative and detectable HBV DNA) was 21.3%. Three parameters were significantly associated with the presence of HBsAg: male [odds ratio (OR): 2.2;P = 0.005; 95% confidence interval (CI): 1.3-3.8]; WHO stage 4 (OR: 3.2;P = 0.01;95% CI: 1.3-7.9); and aspartate aminotransferase (AST) level higher than the standard (OR: 1.9;P = 0.04; 95% CI: 1.02-3.8). CONCLUSION: HBV infection prevalence is high in HIV-positive patients. HBeAg positive chronic hepatitis and occult HBV infection are more frequent in HIVpositive patients than in HIV negative ones. Parameters associated with HBsAg positivity were male gender, AIDS status and increased AST level. | Koffi Alain Attia Serge Eholié Eugène Messou Christine Danel Sandrine Polneau Henri Chenal Thomas Toni Myreille Mbamy Catherine Seyler Naomi Wakasugi Thérèse N'dri-Yoman Xavier Anglaret | 2012 | World Journal of Hepatology2012，4，7： | 4 |
| 4 | Chemical composition and antioxidant activity of the extract and essential oil of Rosa damascena from Iran, Population of Guilan显示文摘 | Yassa N Masoomi F SE R | 2009 | DARU2009，17，3： | 1 |
| 5 | Endovenous laser treatment of saphe- nous vein reflux : long-term results 显示文摘 | Min R J Khilnani N Zimmet SE | 2003 | J Vasc Interv Radiol2003，14，8： | 1 |
| 6 | Chemical composition and antioxidant activity of the extract and essential oil of Rosa damascena from Iran, Population of Guilan显示文摘 | Yassa N Masoomi F SE R | 2009 | DARU2009，17，3： | 1 |
| 7 | Eating soya improves human memory显示文摘 | File SE Jarrett N Fluck E Duffy R Casey K Wiseman H | 2001 | Psychopharmacology (Berl)2001，157，4： | 1 |
| 8 | Influence of in utero diethylstilbestrol exposure on the prognosis and biologic behavior of vaginal clear-cell adenocarcinoma显示文摘 | Waggoner SE Mittendorf R Biney N | 1994 | Gyneeol Oncol1994，55，2： | 1 |
| 9 | Endovenous laser treatment of saphenous vein reflux: long-term results显示文摘 | Min R J Khilnani N Zimmet SE | 2003 | J Vasc Interv Radiol2003，14，8： | 1 |
| 10 | Endovenous laser treatment of saphenous vein reflux: long- term results显示文摘 | Min R J Khilnani N Zimmet SE | 2003 | J Vasc Interv Radiol2003，14，8： | 1 |
| 11 | Immunohistochemical assessment of p16, COX-2 and EGFR in HPV-positive cervical squamous intraepithelial lesion s显示文摘 | Balan R Simion N Giusc a SE | 2011 | Rom J Morphol Embryol2011，2，4： | 1 |
| 12 | A faux 3'UTR promotesaberrant termination and triggers nonsense-mediated mRNA decay显示文摘 | Amrani N Ganesan R Kervestin Se t al | 2004 | Nature2004，432，7013： | 1 |
| 13 | Promoter polymorphim at-238 of the tumor necrosis factor-a gene is not associatel with early onset posoriasis when test by the transmissim disequlibrium test显示文摘 | Jacob N Franz R Marcus SE | 1999 | J ln- evse Dermatol1999，112，： | 1 |
| 14 | Endovenous laser treatment of saphenous vein reflux: long-term results 显示文摘 | Min R J Khilnani N Zimmet SE | 2003 | J Vasc Interv Radiol2003，14，8： | 1 |
| 15 | Comparison ofthe Wells and revised Genevascores for the diagnosisof pulmonary embolism: anAustralian experience显示文摘 | Wong D D Rama se s ha n G Mendel son R M | 2011 | Intern Med J2011，41，： | 1 |
| 16 | Human bloodCXCR5 (+) CD4 (+) T cells are counterparts of T follicularcells and contain specific subsets that differentially supportantibody secretion显示文摘 | Morita R Schmitt N Bentebibel SE | 2011 | Immunity2011，34，1： | 1 |
| 17 | Eating soya improves human memory显示文摘 | File SE Jarrett N Fluck E Duffy R Casey K Wiseman H | 2001 | Psychopharmacology (Berl)2001，157，4： | 1 |
| 18 | Human blood CXCR5 (+-)CD4 (+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion显示文摘 | Morita R Schmitt N Bentebibel SE | | 0，，： | 1 |
| 19 | Endovenous laser treatment of saphenous vein reflux : long - term results 显示文摘 | Min R J Khilnani N Zimmet SE | 2003 | J Vasc Interv Radiol2003，14，8： | 1 |
| 20 | Inertial navigation-forty years of evolution显示文摘 | A D KING B Se F R I N | 1998 | GEC REVIEW1998，13，3： | 1 |
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