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| 1 | Changes in myocardial collagen content before and after left ventricular assist device application in dilated cardiomyopathy显示文摘Background The purposes of this study were to confirm the changes in myocardial collagen level after left ventricular assist device (LVAD) support in dilated cardiomyopathy (DCM), find the relation between these changes and prognosis, an d test a practical method to assess the level of myocardial collagen.Methods Left ventricular samples were collected from DCM patients with different prognosis (transplanted group n=8, weaning group n=10) at the time when the LV ADs were implanted and again during cardiac transplantation (n=8). The level of neutral salt soluble collagen (NSC) and acid soluble collagen (ASC) was measured by Sircol collagen assay, and that of total collagen and insoluble collagen (ISC) by quantification of hydroxyproline (Hyp). Serum samples were collected from a portion of these patients (transplanted group, n=6; weaning group n=7) at the time the LVADs were implanted, 1 month after implantation and on explantation. Circulating concentration of carboxy-terminal propeptide of type Ⅰ procollagen (PⅠCP), amino-terminal propeptide of type Ⅰ procollagen (PⅠNP), amino-terminal propeptide of type Ⅲ procollagen (PⅢNP) and type Ⅰ collagen telopeptide (ⅠCTP) were measured by the equilibrium type radioimmunoassay. Results Before LVAD implantation the level of NSC and ISC in th e weaning group was higher but ASC in the transplanted group was lower than in the control s (P<0.05). After LVAD support, the level of total collagen was higher, but ASC was also lower in the transplanted group than in the controls (P<0.05). In comparison of the pre- and po st-LVAD subgroups of the transplanted and weaning groups, all collagen fraction levels before LVAD implantation were lower in the transplanted group than in the weaning group (P<0.05); but this difference disappeared after LVAD support. Comparison of the pre- and post-LVAD subgroups of the transplanted group showed increased le vel of NSC and total collagen after LVAD support. The changes of serum p eptide concentration showed that PⅢNP increased constantly in the transplanted group, but PⅠCP and PⅠNP increased in the weaning group after LVAD implantation. Conclusions The changes in myocardial collagen level as a sign of myocardial interstitial remodeling in DCM are not involved with total collagen b ut invalved with collagen fractions, and they are related to prognosis. The changes of myocardial c ollagen content and serum procollagen peptide after LVAD support can be regarded as an expression of the reverse of maladaptive myocardial interstitial remodeling. | 梁红 Johannes Müller 翁渝国 Gerd Wallukat 付平 林汉生 Sabina Bartel Christoph Knosalla Reinhard Pregla Roland Hetzer | 2004 | Chinese Medical Journal2004，，3： | 3 |
| 2 | Vorapaxar for secondary prevention of thrombotic events for patients with previous myocardial infarction: a prespecified subgroup analysis of the TRA 2°P-TIMI 50 trial显示文摘 | Benjamin M Scirica Marc P Bonaca Eugene Braunwald Gaetano M De Ferrari Daniel Isaza Basil S Lewis Felix Mehrhof Piera A Merlini Sabina A Murphy Marc S Sabatine Michal Tendera Frans Van de Werf Robert Wilcox David A Morrow | 2012 | The Lancet . 2012 (9850)2012，，9850： | 1 |
| 3 | Development of a biosensor microarray towards food screening using imaging surface plasmon resonance 显示文摘 | SABINA R R MARIA G B GIESBERS M | 2008 | Biosensors and Bioelectronics2008，24，： | 1 |
| 4 | Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure显示文摘 | Mathews D H Sabina J Zuker M | 1999 | Journal of Molecular Biology1999，288，5： | 1 |
| 5 | 6-Shogaol inhibits monosodium urate crystal-induced inflammation- an in vivo and in vitro study 显示文摘 | Sabina E P Rasool M Mathew L | 2010 | Food Chem Toxicol2010，48，1： | 1 |
| 6 | Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure显示文摘 | MATHEWS D H SABINA J ZUKER M | 1999 | Journal of Molecular Biology1999，288，5： | 1 |
| 7 | Comparison of two wet digestion procedures for multi-element analysis of plant samples显示文摘 | Sabina R O Hannu R Maria D M | 2003 | communications in soil science and plant analysis2003，34，1920： | 1 |
| 8 | Molecular characterisation of EmTFP250:a novel member of the TRAP protein family in Eimeria maxima显示文摘 | David M Witcombe Sabina I Belli | 2003 | Int Parasitology2003，33，： | 1 |
| 9 | 临床怀疑深静脉血栓形成病人的压迫超声诊断:前瞻性队列研究显示文摘目的:评价临床上怀疑为深静脉血栓形成但压迫超声显像所见正常病人不给予肝素治疗的安全性。设计:根据一种简化的程序来做压迫超声显像,超声显像的部位限于3处,即腹股沟部的股总静脉、腘静脉及胭静脉远端小腿静脉的分叉部位。初诊时超声显像为正常的病人1周后再重复检查1次。评价结果的标准:对于临床上怀疑为深静脉血栓形成的病人,凡是间隔1周两次超声显像均正常者则不予以肝素治疗,随访6个月,统计在这段时间内静脉血栓栓塞合并症的发生率。参加单位:四所大学附属医院的研究中心。结果:本研究共包括1702名病人,第一次检查发现400名血栓形成者,第二次检查又发现12名,因此用超声诊断方法在该1702名临床上怀疑为深静脉血栓形成的病人中确诊了412例,占24%。全组病人均获得随访,在两次 B 超检查之间,有1例发生了静脉血栓性栓塞的合并症,在6个月随访期间又有8例,所以累计发生率为0.7%(95%可信限为0.3%~1.2%),登门随访及补做检查的次数为平均每例0.8次。结论:对于临床上怀疑为深静脉血栓形成的病人,若连续两次压迫超声检查均为正常者,不给予肝素治疗是安全的。 | Alberto Cogo Anthonie W A Lensing Maria M W Koopman Franco Piovella Sergio Siragusa Philip S Wells Sabina Villalta Harry R Bller Alexander G G Turpie Paolo Prandoni 冷希圣 | 1998 | 英国医学杂志中文版1998，0，1： | 1 |
| 10 | Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure 显示文摘 | Mathews DH Sabina J Zuker M | 1999 | Journal of Molecular Biology1999，288，5： | 1 |
| 11 | Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure显示文摘 | MATHEWS D H SABINA J ZUKER M | 1999 | Journal of Molecular Biology1999，288，5： | 1 |
| 12 | Interactions between chitosans and bacterial suspensions:Adsorption and flocculation 显示文摘 | SABINA P S KJELL M V KJETILL O | 2003 | Colloids and Surfaces B: Biointerfaces2003，27，1： | 1 |
| 13 | Design, structure-activity relationships and in vivo charac- terization 4-amino-3-benzimidazol-2-ylhydroquinolin-2- ones:A novel class of receptor tyrosine kinase inhibitors 显示文摘 | Paul A Renhowe Sabina Pecchi Cynthia M Shafer | 2009 | Journal of Medicinal Chemistry2009，52，2： | 1 |
| 14 | An in vivo and in vitro potential ofIndian ayurvedic herbal formulation Triphala on experimentalgouty arthritis in mice显示文摘 | Sabina EP Rasool M | 2008 | Vascul Pharmacol2008，48，1： | 1 |
| 15 | Effectiveness of electrolyzed acidic water in killing Escherichia coli O157: H7, Salmonella Enteritidis, and Listeria monocytogenes on the surfaces of tomatoes显示文摘 | Bari M L Sabina Y Isobe S | 2003 | Journal of Food Protection2003，66，： | 1 |
| 16 | Interactions between chitosans and bacterial suspensions:adsorption and flocculation显示文摘 | Sabina P Strand Kjell M Varum | 2003 | Colloids and Surfaces Biointerfaces2003，27，3： | 1 |
| 17 | An in vivo and in vitro potential of italian ayurvedic herbal formulation triphala on experimental gouty arthritis in mice显示文摘 | Sabina E P Rasool M | 2008 | Fiseul Pharmacol2008，68，： | 1 |
| 18 | Effectiveness of electrolyzed acidic water in killing Escherichia coli O157 : H7, salmonella enteritidis, and listeria monoeytogenes on the surfaces of tomatoes显示文摘 | Bari M Sabina Y Isobe S | 2003 | Journal of Food Protection2003，66，4： | 1 |
| 19 | 显示文摘 | Todd E M Sabina Cemalovic Manna Warburton | 2006 | Sensor and Acurators B2006，116，： | 1 |
| 20 | Expanded se-quence dependence of thermodynamic parameters improves prediction of RNA secondary structure显示文摘 | MATHEWS D SABINA J ZUKER M | 1999 | Journal of Molecular Biology1999，288，5： | 1 |
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