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| 1 | Ombitasvir/paritaprevir/ritonavir + dasabuvir +/-ribavirin in real world hepatitis C patients显示文摘BACKGROUND The hepatitis C virus(HCV) NS5A inhibitor ABT-267(ombitasvir, OBV), the HCV NS4/4A protease inhibitor ABT-450(paritaprevir, PTV), the CYP3A inhibitor ritonavir(r) and the non-nucleoside NS5B polymerase inhibitor ABT-333(dasabuvir, DSV)(OBV/PTV/r + DSV) with or without ribavirin(RBV) is a direct-acting antiviral regimen approved in the United States and other major countries for the treatment of HCV in genotype 1(GT1) infected patients. Patients with HCV who are considered 'hard-to-cure' have generally been excluded from registration trials due to rigorous study inclusion criteria, presence of comorbidities and previous treatment failures.AIM To investigate the efficacy of this regimen in HCV G1-infected patients historically excluded from clinical trials.METHODS Patients were ≥ 18 years old and chronically infected with HCV GT1(GT1a, GT1b or GT1a/1b). Patients were treatment-na?ve or previously failed a regimen including pegylated interferon/RBV +/-telaprevir, boceprevir, or simeprevir.One hundred patients were treated with the study drug regimen, which was administered for 12 or 24 wk +/-RBV according to GT1 subtype and presence/absence of cirrhosis. Patients were evaluated every 4 wk from treatment day 1 and at 4 and 12 wk after end-of-treatment.RESULTS Many of the patients studied had comorbidities(44.2% hypertensive, 33.7%obese, 20.2% cirrhotic) and 16% previously failed HCV treatment. Ninety-six patients completed study follow-up and 99% achieved 12-wk sustained virologic response. The majority(88.4%) of patients had undetectable HCV RNA by week 4. The most common adverse events were fatigue(12%), headache(10%),insomnia(9%) and diarrhea(8%); none led to treatment discontinuation. Physical and mental patient reported outcomes scores significantly improved after treatment. Almost all(98%) patients were treatment compliant.CONCLUSION In an all-comers HCV GT1 population, 12 or 24-wk of OBV/PTV/r + DSV +/-RBV is highly effective and tolerable and results in better mental and physical health following treatment. | Nicole Loo Eric Lawitz Naim Alkhouri Jennifer Wells Carmen Landaverde Angie Coste Rossalynn Salcido Michael Scott Fred Poordad | 2019 | World Journal of Gastroenterology2019，25，18： | 2 |
| 2 | Animal models in pressure ulcer research显示文摘 | Salcido R Popescu A | 2007 | J Spinal Cord Med2007，30，2： | 1 |
| 3 | Histopathology of pressure ulcers as a result of sequential computer-controlled pressure sessions in a fuzzy rat model显示文摘 | Salcido R Donofrio J C Fisher S B | 1994 | Adv Wound Care1994，7，24： | 1 |
| 4 | Animal models in pressure ulcer research 显示文摘 | SALCIDO R POPESCU A AHN C | 2007 | J Spinal Cord Med2007，30，2： | 1 |
| 5 | Animal models in pressure ulcer research显示文摘 | Salcido R Popescu A Ahn C | 2007 | J Spinal Cord Med2007，30，2： | 1 |
| 6 | Increasing CPR duration prior to first defibrillation does not improve return of spontaneous circulation or survival in swine model of prolonged ventricular fibrillation 显示文摘 | Rittenberger J C Suffoletto B Salcido D | 2008 | Resuscitation2008，79，1： | 1 |
| 7 | Incidence of rearrest after return of spontaneous circulation in out-of-hospital cardiac arrest 显示文摘 | Salcido DD Stephenson AM Condle JP | 2010 | Prehosp Emerg Care2010，14，4： | 1 |
| 8 | Brcal breast tumors contain distinct CD44^+/CD24^- and CDi33^+ cells with cancer stem cell characteristics显示文摘 | Wright MH Calcagno AM Salcido CD | 2008 | Breast Cancer Res2008，10，1： | 1 |
| 9 | :Research partnerships:academia,industry,patients,and clinicians显示文摘 | | 1999 | Adv Wound Care1999，12，5： | 1 |
| 10 | An animal model and computer-controlled surface pressure delivery system for the production of pressure ulcers显示文摘 | Salcido R Fisher S B Donofrio J C | 1995 | J Rehabil Res Dev1995，32，2： | 1 |
| 11 | Animal models in pressure ulcer research显示文摘 | Salcido R Popescu A Ahn C | 2007 | J Spinal Cord Med2007，30，2： | 1 |
| 12 | Coronary perfusionpressure and return of spontaneous circulation after prolongedcardiac arrest 显示文摘 | Reynolds JC Salcido DD Menegazzi JJ | 2010 | Prehosp Emerg Care2010，14，1： | 1 |
| 13 | More than one way to measure a wound: an overview of tools and techniques显示文摘 | Goldman RJ Salcido R | 2002 | Adv Skin Wound Care2002，15，5： | 1 |
| 14 | An animal model and computer-controlled surface pressure delivery system for the production of pressure ulcers显示文摘 | Salcido R Fisher S B Donofrio J C | 1995 | J Reha- bil Res Dev1995，32，2： | 1 |
| 15 | Prolonged drug selection of breast cancer cells and enrichment of cancer stem cell characteristics显示文摘 | Calcagno A M Salcido C D Gillet J P | 2010 | J Natl Cancer Inst2010，102，21： | 1 |
| 16 | Brcal breast tumors contain distinct CD44 +/CD24 and CD133 + cells with cancer stem cell characteristics显示文摘 | Wright MH Calcagno AM Salcido CD | 2008 | Breast Cancer Res2008，10，1： | 1 |
| 17 | Brcal breast tumors contain distinct CD44~/CD24- and CD133~ cells with cancer stem cell characteristics显示文摘 | Wright MH Calcagno AM Salcido CD | 2008 | Breast Cancer Res2008，10，10： | 1 |
| 18 | Molecular characterisation of side population cells with cancer stem cell-like characteristics in small- cell lung cancer显示文摘 | Salcido CD Larochelle A Taylor BJ | 2010 | Br J Cancer2010，102，11： | 1 |
| 19 | Frequency of supernumerary teeth in Mexican population显示文摘 | Salcido Garcia JF Ledesma- Montes C Hernandez Flores F | 2004 | 9(5):403-4092004，9，5： | 1 |
| 20 | Association of in- tramyocardial high energy phosphate concentrations with quantita- tive measures of the ventricular fibrillation electrocardiogram wave- form显示文摘 | Salcido DD Menegazzi JJ Suffoletto BP | 2009 | Resuscitation2009，80，8： | 1 |
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