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| 1 | Progression of diethylnitrosamine-induced hepatic carcinogenesis in carnitine-depleted rats显示文摘AIM:To investigate whether carnitine deficiency is a risk factor during the development of diethylnitrosamine (DENA)-induced hepatic carcinogenesis. METHODS:A total of 60 male Wistar albino rats were divided into six groups with 10 animals in each group.Rats in group 1(control group)received a single intraperitoneal(i.p.)injection of normal saline. Animals in group 2(carnitine-supplemented group) were given L-carnitine(200 mg/kg per day)in drinking water for 8 wk.Animals in group 3(carnitine-depleted group)were given D-carnitine(200 mg/kg per day)and mildronate(200 mg/kg per day)in drinking water for 8 wk.Rats in group 4(DENA group)were injected with a single dose of DENA(200 mg/kg,i.p.)and 2 wk later received a single dose of carbon tetrachloride(2 mL/kg) by gavage as 1:1 dilution in corn oil.Animals in group 5(DENA-carnitine depleted group)received the same treatment as group 3 and group 4.Rats in group 6 (DENA-carnitine supplemented group)received the same treatment as group 2 and group 4.RESULTS:Administration of DENA resulted in a significant increase in alanine transaminase(ALT), gamma-glutamyl transferase(G-GT),alkaline phosphatase(ALP),total bilirubin,thiobarbituric acid reactive substances(TBARS)and total nitrate/ nitrite(NOx)and a significant decrease in reduced glutathione(GSH),glutathione peroxidase(GSHPx), catalase(CAT)and total carnitine content in liver tissues.In the carnitine-depleted rat model,DENA induced a dramatic increase in serum ALT,G-GT,ALP and total bilirubin,as well as a progressive reduction in total carnitine content in liver tissues.Interestingly, L-carnitine supplementation resulted in a complete reversal of the increase in liver enzymes,TBARS and NOx,and a decrease in total carnitine,GSH,GSHPx, and CAT induced by DENA,compared with the control values.Histopathological examination of liver tissues confirmed the biochemical data,where L-carnitine prevented DENA-induced hepatic carcinogenesis while D-carnitine-mildronate aggravated DENA-induced hepatic damage. CONCLUSION:Data from this study suggest for the first time that:(1)carnitine deficiency is a risk factor and should be viewed as a mechanism in DENA- induced hepatic carcinogenesis;(2)oxidative stress plays an important role but is not the only cause of DENA-induced hepatic carcinogenesis;and(3) long-term L-carnitine supplementation prevents the development of DENA-induced liver cancer. | Salim S Al-Rejaie Abdulaziz M Aleisa Abdulaziz A Al-Yahya Saleh A Bakheet Abdulmalik Alsheikh Amal G Fatani Othman A Al-Shabanah Mohamed M Sayed-Ahmed | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
| 2 | Saccharomyces boulardii Does Not Prevent Relapse of Crohn’s Disease显示文摘 | Arnaud Bourreille Guillaume Cadiot Gérard Le Dreau David Laharie Laurent Beaugerie Jean–Louis Dupas Philippe Marteau Patrick Rampal Dominique Moyse Ashraf Saleh Marie–Emmanuelle Le Guern Jean–Paul Galmiche | 2013 | Clinical Gastroenterology and Hepatology2013，，8： | 3 |
| 3 | Microbial ex- pression in soil:methods, applications and challenges 显示文摘 | Saleh L S Miller M Campbell R G | 2005 | Microbiol Methods2005，63，： | 1 |
| 4 | Application of SWAT for the Upper North Bosque Watershed显示文摘 | Saleh A Arnold J G Gassman P W | 2000 | Transactions of the ASAE2000，43，5： | 1 |
| 5 | Total hip replacement for the dislocated hip 显示文摘 | Jaroszynski G Woodgate IG Saleh K J | 2001 | Instr Course Lect2001，50，： | 1 |
| 6 | Factors contributing to poor post-operative abdominal pain management in adult patients:a review显示文摘 | Al Samaraee A Rhind G Saleh U | 2010 | Surgeon2010，8，3： | 1 |
| 7 | Innate immune mechanisms of colitis and colitis - associated colorectal cancer 显示文摘 | SALEH M TRINcIqlERI G | 2011 | Nat Rev Immunol2011，11，1： | 1 |
| 8 | Connected to death: The (unexpurgated) mitochondrial pathway of apoptosis显示文摘 | Spierings D McStay G Saleh M | 2005 | Science2005，310，5745： | 1 |
| 9 | Ultrasound-guided fine-needle aspiration of nonpalpable breast lesions: cytologic and histological findings显示文摘 | Sneige N Fornage BD Saleh G | 1994 | Am J Clin Pathol1994，102，1： | 1 |
| 10 | Effect of intravenous gammaglobulin on circulating and platelet-bound antibody in immune thrombocytopenia显示文摘 | Saleh MN Mori PG | 1989 | Blood1989，73，： | 1 |
| 11 | In ammasomes in infection and in ammation显示文摘 | McIntire C R Yeretssian G Saleh M | 2009 | Apoptosis2009，14，： | 1 |
| 12 | Tech- niques of PIV in stratified two-phase headers显示文摘 | SALEH W BOWDEN R C HASSAN I G | 2010 | Experi- mental Thermal and Fluid Science2010，35，1： | 1 |
| 13 | Reliability and validityof non-invasive imaging of internal carotid artery pseudo-occlusion显示文摘 | Fiirst G Saleh A Wenserski F | 1999 | Stroke1999，30，7： | 1 |
| 14 | Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura显示文摘 | Bussel JB Cheng G Saleh MN | 2007 | N Engl J Med2007，357，22： | 1 |
| 15 | Innate immune mechanisms ofcolitis and colitis-associated colorectal cancer显示文摘 | SALEH M TRINCHIERI G | 2010 | Nature ReviewsImmunology2010，11，1： | 1 |
| 16 | Molecular regulation of inflammation and cell death显示文摘 | Yeretssian G Labb~ K Saleh M | 2008 | Cytokine2008，43，3： | 1 |
| 17 | Innate immune mechanisms of colitis and colitis-associated colorectal cancer显示文摘 | SALEH M TRINCHIERI G | 2010 | Nature Reviews Immunology2010，11，1： | 1 |
| 18 | Working fluids for tow-temperature organic Rankine cycles 显示文摘 | SALEH B KOGLBAUER G WENDLAND M | 2007 | Energy2007，32，7： | 1 |
| 19 | Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura 显示文摘 | Bussel JB Cheng G Saleh MN | 2007 | N Engl J Med2007，357，22： | 1 |
| 20 | Spectrofluorormetric determination of certain quinolone antibacterials using metal chelation显示文摘 | EL-KOMMOS M E SALEH G A EL-GIZAWI S M | 2003 | Talanta2003，60，： | 1 |
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