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| 1 | Genetic ancestry analysis in non-alcoholic fatty liver disease patients from Brazil and Portugal显示文摘AIM:To study the association between genetic ancestry,non-alcoholic fatty liver disease(NAFLD) metabolic characteristics in two cohorts of patients,from Brazil and Portugal. METHODS:We included 131 subjects from Brazil [(n = 45 with simple steatosis(S. Steatosis) and n = 86 with nonalcoholic steatohepatitis(NASH)] and 90 patients from Portugal(n = 66,S. Steatosis; n = 24,NASH). All patients had biopsy-proven NAFLD. In histologic evaluation NAFLD activity score was used to assess histology and more than 5 points defined NASH in this study. Patients were divided into two groups according to histology diagnosis:simple steatosis or non-alcoholic statohepatitis. Genetic ancestry was assessed using real-time polymerase chain reaction. Seven ancestry informative markers(AT3-I/D,LPL,Sb19.3,APO,FYNull,PV92,and CKMM) with the greatest ethnicgeographical differential frequencies(≥ 48%) were used to define genetic ancestry. Data were analyzed using R PROJECTS software. Ancestry allele frequencies between groups were analyzed by GENEPOP onlineand the estimation of genetic ancestry contribution was evaluated by ADMIX-95 software. The 5% alpha-error was considered as significant(P < 0.05). RESULTS:In the Brazilian sample,NASH was significantly more frequent among the elderly patients with diabetes(NASH 56 ± 1.1 years old vs S. Steatosis 51 ± 1.5 years old,P = 3.7 x 10-9),dyslipidemia(NASH 63% vs S. Steatosis 37%,P = 0.009),higher fasting glucose levels(NASH 124 ± 5.2 vs S. Steatosis 106 ± 5.3,P = 0.001) and Homeostatic Model of Assessment index > 2.5 [NASH 5.3(70.8%) vs S. Steatosis 4.6(29.2%) P = 0.04]. In the Portuguese study population,dyslipidemia was present in all patients with NASH(P = 0.03) and hypertension was present in a larger percentage of subjects in the S. Steatosis group(P = 0.003,respectively). The genetic ancestry contribution among Brazilian and Portuguese individuals with NASH was similar to those with S. Steatosis from each cohort(Brazilian cohort:P = 0.75; Portuguese cohort:P = 0.97). Nonetheless,the genetic ancestry contribution of the Brazilian and Portuguese population were different,and a greater European and Amerindian ancestry contribution was detected in the Portuguese population while a higher African genetic ancestry contribution was observed in Brazilian population of both NASH and S. Steatosis groups.CONCLUSION:There was no difference between the genetic ancestry contribution among Brazilian and Portuguese individuals with NASH and S. Steatosis from each cohort. | Lourianne Nascimento Cavalcante Jose Tadeu Stefano Mariana V Machado Daniel F Mazo Fabiola Rabelo Kiyoko Abe Sandes Flair Jose Carrilho Helena Cortez-Pinto Andre Castro Lyra Claudia P de Oliveira | 2015 | World Journal of Hepatology2015，7，10： | 2 |
| 2 | Soil Moisture Retrieval Using Thermal Inertia, Determined with Visible and Thermal Spaceborne Data, Validated for Eu ropean Forest 显示文摘 | Verstraeten W W Veroustraete F van der Sande C J | 2006 | Remote Sensing of Environment2006，101，： | 1 |
| 3 | A randomized, con- trolled, double-blind study evaluating melanin-encapsulated liposomes as a chromophore for laser hair removal of blond, white, and gray hair 显示文摘 | Sand M Bechara F G Sand D | 2007 | Ann Plast Surg2007，58，5： | 1 |
| 4 | Effect of dialysate calcium concentrations on intradialytic blood pressure course in cardiac-compromised patients显示文摘 | van Sande F M Cheriex E C van Kuijk W H | 1998 | Am J Kidney Dis1998，32，1： | 1 |
| 5 | Effect of dialysate temperature on energy balance during hemodia- lysis: quantification of extracorporeal energy transfer 显示文摘 | VAN DER SANDE F M KOOMAN J P BUREMA J H | 1999 | Am J Kidney Dis1999，33，6： | 1 |
| 6 | Xylanase supplementation improves energy digestibility of wheat by-products in grower pigs显示文摘 | Nortey T N Patience J F Sands J S | 2007 | Livestock Science2007，92，1： | 1 |
| 7 | The beryllium-boron system显示文摘 | Sands D E Cline C F Zalkin A | 1961 | Acta Cryst1961，14，3： | 1 |
| 8 | Soil moisture retrieval using thermal inertia, determined with visible and thermal spacebome data, validated for European forests显示文摘 | Verstraeten W W Veroustraete F van der Sande C J | 2006 | Remote Sensing of Environment2006，101，3： | 1 |
| 9 | Long - term mortality prediction of CHADS VASc and HATCH scores in a co- hort of patients with typical atrial flutter显示文摘 | Garcia Seam J Gude Sampedro F Martinez Sande JL | 2015 | Clin Res Cardiol2015，199，： | 1 |
| 10 | Repeat liposuction - curettage treatment of axillary hyperhidrosis is safe and ef- fective显示文摘 | Bechara F G Sand M Tomi N S | 2007 | Br J Dermatol2007，157，： | 1 |
| 11 | Level of au- toimmune antibody in women with infertility: an analysis of 236 cases显示文摘 | Kooman J P Van der Sande F M Leunissen K M | 2013 | China Modem Doctor2013，51，3： | 1 |
| 12 | Soil Moisture Retrieval Using Thermal Inertia,Determinedwith Visible and Thermal Spaceborne Data,Validated for Eu-ropean Forests显示文摘 | Verstraeten W W Veroustraete F Van der Sande C J | 2006 | Remote Sensing of Environment2006，101，3： | 1 |
| 13 | Genome-widelinkage of plasma adiponeetin reveals a major locus onchromosome 3q distinct from the adiponeetin structuralgene; the IRAS family study 显示文摘 | Guo X’ Sand M F Langefeld CD | 2006 | Diabetes2006，55，6： | 1 |
| 14 | Does fusion improve the outcome after decompressive surgery for lumbar spinal stenosis?a twoyear follow-up study involving 5390 patients显示文摘 | Frsth P Michaёlsson K Sandén B | 2013 | Bone Joint J2013，95，7： | 1 |
| 15 | Phototermal measurements of the absorption coefficient of water at 590nm显示文摘 | Fry E Sand Sogandares F M | 1986 | SPIE1986，637，： | 1 |
| 16 | Soil moisture retrieval using thermal inertia,determined with visible and thermal spaceborne data,validated for European Forests显示文摘 | Verstraeten W W Veroustraete F Vander Sande C J | 2006 | Remote Sensing of Environment2006，101，3： | 1 |
| 17 | Hospitalacquired, laboratoryconfirmed bloodstream infections: linking national surveillance data to clinical and financial hospital data to estimate increased length of stay and healthcare costs显示文摘 | Vrijens F Hulstaert F Van de Sande S | 2010 | J Hosp Infect2010，75，3： | 1 |
| 18 | N-CAM exhibits a regulatory function in pathological angiogenesis in oxygen induced retinopathy显示文摘 | H(a)kansson J S(a)thlberg A Wolfhagen Sand F | 2011 | PLoS One2011，6，26： | 1 |
| 19 | Xylanase supplementation improves energy digestibility of wheat by-products in grower pigs显示文摘 | Nortey T N Patience J F Sands J S | 2007 | Livestock Science2007，109，： | 1 |
| 20 | Infliximab maintenance therapy for fistulizing Crohn's disease 显示文摘 | Sands B E Anderson F H Bemstein C N | 2004 | N Engl J Med2004，350，9： | 1 |
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