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| 1 | The Quaternary Structure of NADPH Thioredoxin Reductase C Is Redox-Sensitive显示文摘NADPH thioredoxin reductase C (NTRC ) 是能结合 NADPH thioredoxin reductase (NTR ) 和 thioredoxin (TRX ) 的叶绿体酶为 2-Cys peroxiredoxin (2-Cys PRX ) 的有效减小的活动。因为 NADPH 能在黑暗期间在叶绿体被生产, NTRC 在夜里期间为植物过氧化物 detoxification 起一个关键作用。这里, NTRC 的第四级的结构高度依赖于它的氧化还原作用地位,这被显示出。在 vitro,大多数酶采用了一个 oligomeric 状态在在 NADPH, NADH,或 DTT 的增加之上的 dimers 的那 disaggregated。胶化过滤和从 Arabidopsis 叶绿体基质的蛋白质摘录的西方的污点分析证明本国的 NTRC 形成总数,它对 NADPH 和 DTT 敏感,建议聚集状态可能是在 vivo 的 NTRC 活动的一个重要方面。而且,酶在在 Arabidopsis 叶绿体的簇是局部性的。NTRC 三倍、双的异种, A164G-V182E-R183F 和 A164G-R183F,代替 NADPH 有约束力的地点的关键残余,显示出减少的活动,但是仍然能随中间人形式的增加不过使聚合成二聚物。把结果基于这些,我们建议 NTRC 的催化地活跃的形式更暗淡,形成它被 NADPH 导致。 | Juan Manuel Pérez-Ruiz Maricruz Gonzalez Maria Cristina Spinola Luisa Maria Sandalio Francisco Javier Cejudo | 2009 | Molecular Plant2009,2,3: | 3 |
| 2 | Understanding the pathogenesis of hip fracture in the elderly, osteoporotic theory is not reflected in the outcome of prevention programmes显示文摘Hip fractures are an acute and worsening public health problem. They mainly affect elderly people, a population group that is highly vulnerable to disease and accidents, and to falls in particular. Although it has been suggested that osteoporosis is the cause of hip fractures, they mainly occur after a fall has been suffered. The underlying causes of a fall are not related to osteoporosis, although pharmaceutical companies have coined the term 'osteoporotic fracture' for hip fractures in the elderly. Drug treatments for osteoporosis have not diminished the frequency of these injuries, nor have they prevented the occurrence of a subsequent fracture. Since pharmaceutical interests require osteoporosis to be considered a disease, rather than a normal condition of senescence, they go further by assuming that treatment for osteoporosis is essential, and that this policy will diminish the incidence of hip fractures. On the other hand, the origin and treatment of conditions that may be conducive to provoking falls are very difficult to elucidate. In this paper, we consider some of the medical and social problems that arise in this area, as well as conflicts of interest regarding the aetiopathogenesis and prevention of hip fracture, and propose a new paradigm for the prevention of falls. | Enrique Guerado Rosa M Sandalio Zaira Caracuel Enrique Caso | 2016 | World Journal of Orthopedics2016,7,4: | 3 |
| 3 | Localization of manganese-superoxide dismutase in peroxisomes isolated from Pisum sativum L显示文摘 | Sandalio L M Palma J M del Río L A | 1987 | Plant Science1987,51,: | 1 |
| 4 | Cadmium induced changes in the growth and oxidative metabolism of pea plants显示文摘 | Sandalio L M Dalurzo H C Gomez M | 2001 | Journal of Experiment Botany2001,52,: | 1 |
| 5 | Cadmium-induced changes in the growth and oxidative metabolism of pea plants显示文摘 | SANDALIO L M DALURZO H C GOMEZ M | | 0,,: | 1 |
| 6 | Cadmium-induced changes in the growth and oxidative metabolism of pea plants显示文摘 | SANDALIO L M DALURZO H C GOMEZ M | 2001 | Journal of Experimantal Botany2001,52,364: | 1 |
| 7 | Cadmium - induced changes in thegrowth and oxidative metabolism of pea plants 显示文摘 | Sandalio L M | 2001 | Journal ofExperimental Botany2001,52,364: | 1 |
| 8 | Cadmium-induced changes in the growth and oxidative metabolism of pea plants显示文摘 | Sandalio L M Dalurzo H C Gomez M | 2001 | Journal of Experimental Botany2001,364,52: | 1 |
| 9 | Cadmium -inducedchanges in the growth and oxidative metabolism of pea plants显示文摘 | Sandalio L M Dalurzo H C Gomez M | 2001 | Jour-nal of Experimental Botany2001,52,364: | 1 |
| 10 | Cadmium-induced changes in the growth and oxidative metabolism of pea plants显示文摘 | Sandalio L M Dalurzo H C Gomez M | 2001 | Journal of Experimental Botany2001,364,52: | 1 |
| 11 | Reactive oxy- gen species, antioxidant systems and nitric oxide in per- oxisomes显示文摘 | Del Rio L A Corpas F J Sandalio LM | 2002 | J Exp Bot2002,53,: | 1 |
| 12 | Constitutive arginine-dependent nitric oxide synthase activity in different organs of pea seedlings during plant development显示文摘 | CORPAS F J BARROSO J B CARRERAS A VALDERRAMA R PALMA J M LEON A M SANDALIO L M DEL RIO L A | 2006 | Planta2006,224,2: | 1 |
| 13 | Peroxisomal NADP-dependent isocitrate dehydrogenase,characterization and activity regulation during natural senescence显示文摘 | CORPOS F J BARROSO J B SANDALIO L M | 1999 | Plant Physiology1999,121,: | 1 |
| 14 | Cadmium induced changes in the growth and oxidative metabolism of pea plants显示文摘 | Sandalio L M Dalurzo H C Gomez M | 2001 | Journal of Experiment Botany2001,52,: | 1 |
| 15 | Cadmium-induced changes in the growth and oxidative metabolism of pea plants显示文摘 | Sandalio L M Dalurzo H C Gomez M | 2001 | J Exp Botany2001,52,: | 1 |
| 16 | Mitochondrial andperoxisomal manganese superoxide dismutase:differential expres-sion during leaf senescences显示文摘 | del Río L A Sandalio L M Altomare D A | 2003 | J Exp Bot2003,54,92: | 1 |
| 17 | Antioxidative enzymes from chloroplasts,mitochondria,and peroxisomes during leaf senescence ofnodulated pea plants显示文摘 | PalmaJ M Jim6nez A Sandalio L M | 2006 | Journal of Experimental Botany2006,57,: | 1 |
| 18 | Cadmium-induced changes in the growth and oxidative metabolism of pea plants显示文摘 | SANDALIO L M DALRUZO H C GOMEZ M | 2001 | Journal of Experimental Botany2001,52,: | 1 |
| 19 | Localization of manganese- superoxide dismutase in peroxisomes isolated from Pisum sativum L显示文摘 | SANDALIO LM PALMA JM DELRIO LA | 1987 | Plant Science1987,51,: | 1 |
| 20 | Cadmium-induced changes in the growth and oxidative metabolism of pea plants显示文摘 | Sandalio L M Dalurzo H C Gomez M | 2001 | Journal of Experimental Botany2001,52,364: | 1 |