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| 1 | Alcoholic disease: Liver and beyond显示文摘The harmful use of alcohol is a worldwide problem.It has been estimated that alcohol abuse represents the world’s third largest risk factor for disease and disability;it is a causal factor of 60 types of diseases and injuries and a concurrent cause of at least 200 others.Liver is the main organ responsible for metabolizing ethanol,thus it has been considered for long time the major victim of the harmful use of alcohol.Ethanol and its bioactive products,acetaldehyde-acetate,fatty acid ethanol esters,ethanol-protein adducts,have been regarded as hepatotoxins that directly and indirectly exert their toxic effect on the liver.A similar mechanism has been postulated for the alcohol-related pancreatic damage.Alcohol and its metabolites directly injure acinar cells and elicit stellate cells to produce and deposit extracellular matrix thus triggering the'necrosis-fibrosis'sequence that finally leads to atrophy and fibrosis,morphological hallmarks of alcoholic chronic pancreatitis.Even if less attention has been paid to the upper and lower gastrointestinal tract,ethanol produces harmful effects by inducing:(1)direct damaging of the mucosa of the esophagus and stomach;(2)modification of thesphincterial pressure and impairment of motility;and(3)alteration of gastric acid output.In the intestine,ethanol can damage the intestinal mucosa directly or indirectly by altering the resident microflora and impairing the mucosal immune system.Notably,disruption of the intestinal mucosal barrier of the small and large intestine contribute to liver damage.This review summarizes the most clinically relevant alcohol-related diseases of the digestive tract focusing on the pathogenic mechanisms by which ethanol damages liver,pancreas and gastrointestinal tract. | Alba Rocco Debora Compare Debora Angrisani Marco Sanduzzi Zamparelli Gerardo Nardone | 2014 | World Journal of Gastroenterology2014，20，40： | 27 |
| 2 | COPD:adherence to therapy显示文摘 | Sanduzzi A Balbo P Candoli P | 2014 | Multidiscip Respir Med2014，9，1： | 1 |
| 3 | Role of mycobacteriainduced monocyte/macrophage apoptosis in the pathogenesis of human tuberculosis显示文摘 | Bocchino M Galati D Sanduzzi A | 2005 | Int J Tuberc Lung Dis2005，9，4： | 1 |
| 4 | Carcinoembryonic antigen mRNA analysis detects micrometastatic cells in blood from lung cancer patients显示文摘 | Castaldo G Tomaiuolom R Sanduzzi A | 2003 | Eur Respir J2003，22，3： | 1 |
| 5 | COPD: adherence to therapy 显示文摘 | Sanduzzi A Balbo P Candoli P | 2014 | Multidiscip Respir Med2014，9，1： | 1 |
| 6 | Role of myco- bacteria-induced monocyte/macrophage apoptosis in the pathogenesis o{ human tuherculosis显示文摘 | Bocchino M Galati D Sanduzzi A | 2005 | The In- ternational Journal of Tuberculosis and Lung Dis- ease2005，9，4： | 1 |
| 7 | Carcinoembryonic antigen mRNA analysis detects micrometastatic cells in blood from lung cancer patients显示文摘 | Tomaiuolo R Sanduzzi A | 2003 | Eur RespirJ2003，22，3： | 1 |
| 8 | Lung cancer metastatic cells detected in blood by reverse transcriptase polymerase chain reaction and dot-blot analysis显示文摘 | Castaldo G Tomaiuolo R Sanduzzi A | 1997 | J Clin Oncol1997，15，11： | 1 |
| 9 | Role of mycobacteria-induced monocyte/macrophage apoptosis in the pathogenesis of human tuberculgsis显示文摘 | Bocchino M Galati D Sanduzzi A | 2005 | Int J Tuberc Lung Dis2005，9，4： | 1 |
| 10 | Lung cancer metastatic cells detected in blood by reverse transcriptase-polymerase chain reaction and dot blot analysis 显示文摘 | Castaldo G Tomaiuolo R Sanduzzi A | 1997 | J Clin Oncol1997，15，11： | 1 |
| 11 | COPD :adherence to therapy 显示文摘 | Sanduzzi A Balbo P Candoli P | 2014 | Multidiseip Respir Med2014，9，1： | 1 |
| 12 | Role of mycobacteriainduced monocyte/macrophage apoptosis in the pathogenesis of human tuberculosis 显示文摘 | Bocchino M Galati D Sanduzzi A | 2005 | Int J Tuberc Lung Dis2005，9，4： | 1 |
| 13 | Carcinoembryonic antigen mRNA analysis detects micrometastatic cells in blood from lung cancer patients显示文摘 | Castaldo G Tomaiuolo R Sanduzzi A | 2003 | Eur Respir J2003，22，3： | 1 |
| 14 | Carcinoma baryonic anti- gen mRNA analysis detects micro metastatic cells in blood from lung cancer patients 显示文摘 | Castaldo G Tomaiuoio R Sanduzzi A | 2003 | Eur Respir J2003，22，7： | 1 |
| 15 | Role of mycobacteria-induced monocyte/macrophage apoptosis in the pathogenesis of human tuberculosis显示文摘 | Bocchino M Galati D Sanduzzi A Colizzi V Brunetti E Mancino G | 2005 | Int J Tuberc Lung Dis2005，9，4： | 1 |
| 16 | Carcincem- bryonic antigen mRNA analysis detects micrometastatic cells in blood from lung cancer patients显示文摘 | Castaldo G Tomaiuolo R Sanduzzi A | 2003 | Eur Respir2003，22，3： | 1 |
| 17 | Carcinoembryonic antigen mRNA analysis detects micrometastatic cells in blood from lung cancer patients显示文摘 | Castaldo G Tomaiuolo R Sanduzzi A | 2003 | Eur Respir J2003，22，3： | 1 |
| 18 | Treating severe allergic asthma with anti-Ig E monoclonal antibody(omalizumab):a review显示文摘 | D'Amato G Stanziola A Sanduzzi A | 2014 | Multidiscip Respir Med2014，9，1： | 1 |
| 19 | Carcinoembryonic antigen mRNA analysis detects mierometastatle eells in blood from 1 ung eaneerpatients显示文摘 | Castaldo G Tomaiuolo R Sanduzzi A | 2003 | Enr Respir J2003，22，3： | 1 |
| 20 | Performance of the tuberculin skintest and interferon-gamma release assays an update on the accuracy,cutoff stratification, and new potential immune-based approaches 显示文摘 | Goletti D Sanduzzi A Delogu G | 2014 | J Rheumatol Suppl2014，91，： | 1 |
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