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| 1 | Complications of radiofrequency ablation of hepatic tumors:Frequency and risk factors显示文摘Radiofrequency ablation(RFA)has become an important option in the therapy of primary and secondary hepatic tumors.Surgical resection is still the best treatment option,but only a few of these patients are candidates for surgery:multilobar disease,insufficient liver reserve that will lead to liver failure after resection,extra-hepatic disease,proximity to major bile ducts and vessels,and co-morbidities.RFA has a low mortality and morbidity rate and is considered to be safe.Thus,complications occur and vary widely in the literature.Complications are caused by thermal damage,direct needle injury,infection and the patient’s co-morbidities.Tumor type,type of approach,number of lesions,tumor localization,underlying hepatic disease,the physician’s experience,associated hepatic resection and lesion size have been described as factors significantly associated with complications.The physician in charge should promptly recognize high-risk patients more susceptible to complications,perform a close post procedure follow-up and manage them early and adequately if they occur.We aim to describe complications from RFA of hepatic tumors and their risk factors,as well as a few techniques to avoid them.This way,others can decrease their morbidity rates with better outcomes. | Alexandre Zanchenko Fonseca Stephanie Santin Luiz Guilherme Lisboa Gomes Jaques Waisberg Marcelo Augusto Fontenelle Ribeiro Jr. | 2014 | World Journal of Hepatology2014，6，3： | 24 |
| 2 | Giant squamous cell carcinoma of the gallbladder: A case report显示文摘BACKGROUND Gallbladder cancer is the most common malignant tumor of the biliary tract. The majority of cases are adenocarcinoma. Squamous cell carcinoma is the histological type present in 12% of all neoplasias accounting for approximately 12% of gallbladder neoplasms. It can occur in its pure form reaching 1%-3% of the tumors. Many patients are at an advanced stage when diagnosed and have bad therapeutic efficacy. CASE SUMMARY A 45-year-old male patient presented with left flank pain for 1 year and irradiated to the mesogastric region. He denied fever, vomiting, and any other intestinal changes. He reported a weight loss of 10 kg in a period of 7 mo. He denied alcoholism, smoking, drug use, or prior illness. Computed tomography of the abdomen showed in the gallbladder fossa a voluminous mesogastric heterogeneous collection that had a thick and irregular capsule with liquid and gaseous contents. A predominantly hypoattenuating rounded material with partially calcified margins measuring about 2.0 cm related to gallstone was also emphasized. No lymphadenomegalies or free fluid was observed in the abdominal cavity. Patient underwent laparotomy where a huge tumor was observed affecting the transverse colon and gallbladder. This mass was resected en bloc removing gallbladder and transverse colon together with corresponding mesocolon and regional lymphadenectomy. There were no complications in the postoperative period. Although oncological treatment was performed, the patient died 6 mo after surgery. CONCLUSION Squamous cell carcinoma represents a rare disease. Patients often present with large, bulky tumors with involvement of adjacent organs. In spite of progress in surgical techniques and adjuvant chemotherapy, the prognosis remains poor. | Marcelo AF Ribeiro Junior Murillo de Lima Favaro Stephanie Santin Cintia Magalhaes Silva Ana Paula Marconi Iamarino | 2019 | World Journal of Clinical Cases2019，7，18： | 2 |
| 3 | Ⅱ型表皮生长因子受体(HER2/neu)过度表达的种族差异:子宫浆液性乳头状癌的主要预后指标 | Santin A.D. Bellone S. Siegel E.R. 朱国栋 | 2005 | 世界核心医学期刊文摘(妇产科学分册)2005，0，7： | 2 |
| 4 | 采用HPV16/18型E7肽冲击的树突状细胞免疫复发性难治型宫颈癌显示文摘Objective. To evaluate the potential of human papillomavirus (HPV) type 16 and 18 E7 antigen-loaded autologous dendritic cells (DC) as a therapeutic cellular vaccine in a case series of cervical cancer patients harboring recurrent/metastatic disease refractory to standard treatment modalities. Methods. Autologous monocyte-derived DC were pulsed with recombinant HPV16 E7 or HPV18 E7 oncoproteins and administered to 4 cervical cancer patients. Vaccinations were followed by subcutaneous administration twice daily of low doses of human recombinant interleukin- 2 (1 × 106 IU/m2) from day 3 to day 7. Safety, toxicity, delayed type hypersensitivity reactions (DTH), clinical responses, and induction of serological and cellular immunity against HPV16/18 E7 were monitored. Results. The vaccine was well- tolerated in all patients and no local or systemic side effects or toxicity were recorded. Three out of four patients were found to be significantly immunocompromised before starting the vaccination treatment, as assessed by DTH with a panel of recall antigens. Specific humoral and cellular CD4+ T cell responses to the E7 vaccine were detected in 2 patients, as detected by ELISA and by IFN- γ ELISpot assays, respectively. Increased numbers of E7- specific IFN- γ secreting CD8+ T cells were detected in all patients after vaccination. Swelling and induration (i.e., a positive DTH response) to the intradermal injection of HPV E7 oncoprotein and/or irradiated autologous tumor cells were detected in two patients after six vaccinations. No objective clinical responses were observed. However, both patients who developed a positive DTH to the vaccine experienced a slow tumor progression (i.e., 13 months survival)while DTH unresponsive patients died within 5 months from the beginning of therapy. Conclusions. Autologous DC pulsed with HPV16/18 E7 proteins can induce systemic B and T cell responses in patients unresponsive to standard treatment modalities. However, treatment-induced immunosuppression may impose severe limitations on the efficacy of active vaccination strategies in late stage cervical cancer patients. DC-based vaccination trials are warranted in immunocompetent cervical cancer patients with early stage disease and/or limited tumor burden, and at significant risk for tumor recurrence or disease progression. | Santin A.D. Bellone S. Palmieri M. 李奎 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，8： | 2 |
| 5 | Restoration of tumor specific human leukocyte antigens class Ⅰ -restricted cytotoxicity by dendritic cell stimulation of tumor infiltrating lymphocytes in patients with advanced ovarian cancer 显示文摘 | Santin AD Bellone S Pahnieri M | 2004 | Int J Gynecol Cancer2004，14，1： | 1 |
| 6 | Secretion of vascular eudothelial growth factor in ovarian cancer显示文摘 | Hermonat PL Ravaggi A | 1999 | Eur J Gynaecol Oncol1999，20，3： | 1 |
| 7 | Giardia and Cryptosporidium species and genotypes in coyotes (Canis latrans) 显示文摘 | Trout J M Santin M Fayer R | 2006 | J Zoo Wild Med2006，37，2： | 1 |
| 8 | Impact of hepatitis C virus coinfection on immune restoration during successful antiretroviral therapy in chronic human immunodeficiency virus type 1 disease显示文摘 | Santin M Mestre M Shaw E | 2008 | Eur J Clin Microbiol Infect Dis2008，27，1： | 1 |
| 9 | Induction of ovarian tumor-specific CD8^ + cytotoxic T lymphocytes by acid-eluted peptide-pulsed autologous dendritic cells 显示文摘 | Santin AD Bellone S Ravaggi A | 2000 | Obstet Gynecol2000，96，3： | 1 |
| 10 | Effects of mammillary body lesions on spatial reference and working memory tasks显示文摘 | Santin LJ Rubio S Begega A | 1999 | Behav Brain Res1999，102，12： | 1 |
| 11 | Overexpre- ssion of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in uterine carcinosarcomas 显示文摘 | Santin AD Bellone S Siegel ER | 2007 | Clin Cancer Res2007，13，11： | 1 |
| 12 | Clinical and subclinical infections with Cryptosporidium in animals显示文摘 | Santin M | 2013 | N Z Vet J2013，61，1： | 1 |
| 13 | Long-term relapses after 12month treatment for Mycobacterium kansasii lung disease显示文摘 | Santin M Dorea J Alcaide F | 2009 | Eur Respir J2009，，33： | 1 |
| 14 | Overexpression of Claudia-3 and claudin-4 receptors in uterine serous papillary carcinoma:novel targets for a type-specific therapy using Clostridium perfringens enterotoxin (CPE)显示文摘 | Santin AD Bellone S Marizzoni M | 2007 | Cancer2007，109，7： | 1 |
| 15 | The performance of PEGylated nanocapsules of perfluorooctyl bromide as an ultrasound contrast agent 显示文摘 | Diaz-Lopez R Tsapis N Santin M | 2010 | Biomaterials2010，31，7： | 1 |
| 16 | Prevalence of species and genotypes of Cryptosporidium found in 1 -2 -year-old dairy cattle in the eastern United States显示文摘 | Santin M Trout JM | 2006 | Veterinary Paraitology2006，135，2： | 1 |
| 17 | Diagnosis of tuberculosis infection using interferon-T-based assays显示文摘 | Santin Cerosales M Benitez JD | 2011 | Enferm Infecc Microbiol Clin2011，29，1： | 1 |
| 18 | Gene expression fingerprint of uterine serous papillary carcinoma: identification of novel molecular markers for uterine serous cancer diagnosis and therapy 显示文摘 | Santin AD Zhan F Cane S | 2005 | Br J Cancer2005，92，8： | 1 |
| 19 | GATE: A simulation toolkit for PET and SPECT显示文摘 | Jan S Santin G Strul D | 2004 | Physics in Medicine and Biology2004，49，19： | 1 |
| 20 | Effects of retinoic acid combined with interferon on expression of major histocompatibility complex molecules and intercellular adhesion molecules in human cervicalancer显示文摘 | Alessandro D Santin | 1998 | Int J Cancer1998，75，2： | 1 |
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