|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Long-term durable response to lenalidomide in a patient with hepatic epithelioid hemangioendothelioma显示文摘Epithelioid hemangioendothelioma(EH)is a rare tumor arising from the vascular endothelial cells of soft tissue or visceral organs.The most common visceral site is the liver,where it is often involved in a multifocal man-ner known as hepatic EH(HEH).Surgical resection with curative intent represents the gold standard therapy.When surgery is not feasible,or in cases of metastatic disease,no standard medical treatment is currently indicated.In small series,drugs with anti-angiogenic activity(such as bevacizumab,sorafenib,thalidomide,and lenalidomide)have been proposed with promising results.We describe a 73-year-old man with multifocal non-resectable HEH treated with lenalidomide.Disease status was evaluated by abdominal ultrasound and magnetic resonance every four months.The patient was treated for a total of 39 mo with prolonged disease stabilization and,at the time of writing,is still under treatment with a good tolerance profile.During a short period of treatment discontinuation,the disease showed slight progression that immediately resolved after the reintroduction of lenalidomide.Lenalidomide may represent a valid treatment option for HEH due to its anti-angiogenic and antineoplastic activities.This preliminary result merits further study in a large series. | Maria Caterina Pallotti Margherita Nannini Claudio Agostinelli Simona Leoni Valerio Di Scioscio Anna Mandrioli Cristian Lolli Maristella Saponara Stefano Pileri Luigi Bolondi Guido Biasco Maria Abbondanza Pantaleo | 2014 | World Journal of Gastroenterology2014，20，22： | 9 |
| 2 | Current status of the adjuvant therapy in uterine sarcoma: A literature review显示文摘Uterine sarcomas (US) are rare mesenchymal tumours accounting approximately for 3%–7% of all uterine cancers. Histologically, US are classified into mesenchymal tumours or mixed epithelial and mesenchymal tumours. The group of mesenchymal tumours includes uterine leiomyosarcoma (uLMS, 65% of cases), endometrial stromal sarcoma (ESS, 21%)– traditionally divided into low grade (LG-ESS) and high grade–undifferentiated uterine sarcoma (5%) and other rare subtypes such as alveolar or embryonal rhabdomyosarcoma. Despite the fact that several drugs demonstrated clinical activity in advanced or metastatic settings, the role of postoperative therapy in US remains controversial. In this review, we have summarised the current state of the art, including the chief trials on adjuvant treatment modalities in US, especially focusing on uLMS, LG-ESS and other rare histotypes. | Alessandro Rizzo Maria Abbondanza Pantaleo Maristella Saponara Margherita Nannini | 2019 | World Journal of Clinical Cases2019，7，14： | 3 |
| 3 | Successful multidisciplinary clinical approach and molecular characterization by whole transcriptome sequencing of a cardiac myxofibrosarcoma: A case report显示文摘BACKGROUND Cardiac tumors are rare and complex entities.Surgery represents the cornerstone of therapy,while the role of adjuvant treatment remains unclear and,in case of relapse or metastatic disease,the prognosis is very poor.Lack of prospective,randomized clinical trials hinders the generation of high level evidence for the optimal diagnostic workup and multimodal treatment of cardiac sarcomas.Herein,we describe the multidisciplinary clinical management and molecular characterization of a rare case of cardiac myxofibrosarcoma in an elderly woman.CASE SUMMARY A 73-year-old woman presented signs and symptoms of acute left-sided heart failure.Imaging examination revealed a large,left atrial mass.With suspicion of a myxoma,she underwent surgery,and symptoms were promptly relieved.Histology showed a cardiac myxofibrosarcoma,a rare histotype of cardiac sarcoma.Eight months later,disease unfortunately relapsed,and after a multidisciplinary discussion,a chemotherapy with doxorubicin and then gemcitabine was started,achieving partial radiologic and complete metabolic response,which was maintained up to 2 years and is still present.This report is focused on the entire clinical path of our patient from diagnosis to follow-up,through surgery and strategies adopted at relapse.Moreover,due to their rarity,very little is known about the molecular landscape of myxofibrosarcomas.Thus,we also performed and described preliminary genome analysis of the tumor tissue to get further insight on mechanisms involved in tumor growth,and to possibly unveil new clinically actionable targets.CONCLUSION We report a case of cardiac myxofibrosarcoma that achieved a very good prognosis due to an integrated surgical,cardiac and oncologic treatment strategy. | Maristella Saponara Valentina Indio Carmine Pizzi Elena-Daniela Serban Milena Urbini Annalisa Astolfi Pasquale Paolisso Sofia Martin Suarez Margherita Nannini Davide Pacini Valentina Agostini Ornella Leone Valentina Ambrosini Giuseppe Tarantino Stefano Fanti Fabio Niro Francesco Buia Domenico Attinà Maria Abbondanza Pantaleo | 2019 | World Journal of Clinical Cases2019，7，19： | 2 |
| 4 | Enamel microhardness after in vitro demineralization and role of different restorative materials 显示文摘 | Savarino L Saponara Teutonico A Tarabusi C | 2002 | J Biomater Sci Polym Ed2002，13，3： | 1 |
| 5 | Radiation tolerant spacewire router for satellite on-board networking 显示文摘 | SAPONARA S FANUCCI L TONAREFLI M | 2007 | Aerospace and Electronic Systems Magazine2007，22，5： | 1 |
| 6 | Architectural-Level Power Optimization of Microcontroller Cores in Embedded Systems 显示文摘 | S Saponara L Fanucci P Terreni | 2007 | IEEE Transactions on Industrial Electronics2007，54，1： | 1 |
| 7 | Lack of ERK activation and cell migration in FGF-2-deficient endothelial cells显示文摘 | Pintucci G Moscatelli D Saponara F | 2002 | FASEB J2002，16，6： | 1 |
| 8 | Quercetin as a novel ac- tivator of Ltype Caz+ channels in rat tail artery smooth muscle cells显示文摘 | Saponara S Giampietro S Fabio E | 2002 | Br J Pharmaeol2002，135，7： | 1 |
| 9 | Algorithmic and Architectural Design for Real-time and Power-efficient Retinex Image/video Processing显示文摘 | Saponara S Fanucci L Marsi S | 2007 | Journal of Real-time Image Processing2007，1，4： | 1 |
| 10 | Lack of ERK activation and cell migration in FGF-2-deficient endothelial cells 显示文摘 | Pintucci G Moscatelli D Saponara F | 2002 | FASEB J2002，16，6： | 1 |
| 11 | Impressive long- term disease stabilization by nilotinib in two pretreated patients with KIT/PDGFRA wild-type metastatic gastrointestinal stromaltumours显示文摘 | Pantaleo MA Nannini M Saponara M | 2012 | Anticancer Drugs2012，23，： | 1 |
| 12 | Supratentorial atrophy in spinocerebellar ataxia type 2:MRI study of 20 patients显示文摘 | Giuffrida S Saponara R Restivo DA | 1999 | J Neurol1999，246，5： | 1 |
| 13 | Environmental and chemical degradation ofcarbon/epoxy and structural adhesive for aerospace applica-tions:Fickian and anomalous diffusion,arrhenius kinetics显示文摘 | SAPONARA V L | 2011 | Composite Structures2011，93，： | 1 |
| 14 | Rapid maxillary expansion in children with obstructive sleep apnea syndrome显示文摘 | Pirelli P Saponara M Guilleminault C | 2004 | Sleep2004，27，4： | 1 |
| 15 | Obstructive Sleep Apnoea Syndrome ( OSAS ) and rhino-tubaric disfunction in children: therapeutic effects of RME therapy显示文摘 | Pirelli P Saponara M Attanasio G | 2004 | Prog Orthod2004，6，1： | 1 |
| 16 | Enamel microhardness after in vitro demineralization and role of different restorative materials显示文摘 | Savarino L Saponara Teutonico A Tarabusi C | 2002 | Biomater Sci Polym Ed2002，13，3： | 1 |
| 17 | Priva- cy and security in wireless sensor networks : protocols, al- gorithms, and efficient archi!ectures 显示文摘 | SAPONARA S SOLANAS A AVOINE G | 2013 | Journal of Com- puter Networks and Communications2013，，2013： | 1 |
| 18 | Lack of ERK activation and cellmigration in FGF-2-deficient endothelial cells显示文摘 | Pintucci G Moscatelli D Saponara F | 2002 | FASEB J2002，16，： | 1 |
| 19 | Rapid maxillary expansion in children with obstructive sleep apnea syndrome显示文摘 | Pirelli P Saponara M Guilleminault C | 2004 | Sleep2004，27，： | 1 |
| 20 | Forest models defined by field measurements II estimation, error analysis and dynamics 显示文摘 | Pacala S W Canham C D Saponara J | 1996 | Ecol Monogr1996，66，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员