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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Endoscopic features of early-stage signet-ring-cell carcinoma of the stomach显示文摘AIM: To identify the features of early signet ring cell gastric carcinoma using magnification endoscopy with narrow band imaging(NBI).METHODS: A retrospective review was conducted of 12 cases of early signet ring cell gastric carcinoma who underwent treatment in a single institution between January 2009 and April 2013. All patients had magnification endoscopy with NBI and indigo carmine contrast to closely examine the mucosal architecture, including the microvasculature and arrangement of gastric pits. Histologic examination of the final endoscopic submucosal dissection or gastrectomy specimen was performed and compared with the endoscopic findings to identify patterns specific to signet ring cell carcinoma.RESULTS: Twelve patients with early signet ring cell gastric carcinoma were identified; 75% were male, and average age was 61 years. Most of the lesions were stage T1a(83%), while the remainder were T1b(17%). The mean lesion size was 1.4 cm2. On standard endoscopy, all 12 patients had a pale, flat lesion without any evidence of mucosal abnormality such as ulceration, elevation, or depression. On magnification endoscopywith NBI, all of the patients had irregularities in the glands and microvasculature consistent with early gastric cancer. In addition, all 12 patients exhibited the 'stretch sign', an elongation or expansion of the architectural structure. Histologic examination of the resected specimens demonstrated an expanded and edematous mucosal layer infiltrated with tumor cells.CONCLUSION: The 'stretch sign' appears to be specific for signet ring cell carcinoma and may aid in the early diagnosis and treatment of this aggressive pathology. | Chainarong Phalanusitthepha Kevin L Grimes Haruo Ikeda Hiroki Sato Chiaki Sato Chananya Hokierti Haruhiro Inoue | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，7： | 8 |
| 3 | Rhodium(I)-or ruthenium(II)-catalyzed direct coupling of vinyl ketones with aldehydes and the subsequent reduction to give aldol derivatives anti-selectively显示文摘 | Sato S Matsuda L Shibata M | 1989 | J Organomet Chem1989，377，： | 1 |
| 4 | Effect of inhaled vancomycin hydrochloride on elimination of methicillin-resistant staphyl ococcusaureus显示文摘 | S hiral M L dc K Sato M | 1995 | Nippon Kyobu Shikkan Gakkai Zasshi1995，33，11： | 1 |
| 5 | Increased left ventricular mass in normotensive type 1 diabetic patients with diabetic nephropathy显示文摘 | Sato A Tarnow L Parving HH | 1998 | Diabetes Care1998，21，9： | 1 |
| 6 | A Study of the Dizcharge Procezs of Manganese Oxide in Borate Solution Using in situ Techniques 显示文摘 | Mishima B A L D Ohtsuka T Sato N | 1993 | Electrochimica Acta ( SO013 -4686 )1993，38，： | 1 |
| 7 | First-principles theory of dilute magnetic semiconductors 显示文摘 | SATO K BERGQVIST L KUDRNOVSKY J | 2010 | Rev Mod Phys2010，82，2： | 1 |
| 8 | Prostaglandin E2 activates the histaminergic system via the EP4 receptor to induce wakefulness in rats 显示文摘 | HUANG Z L SATO Y MOCHIZUKI T | 2003 | J Neurosci2003，23，14： | 1 |
| 9 | Recognition of single-stranded RNA viruses by Toll-like receptor 7显示文摘 | Lund JM Alexopoulou L Sato A | 2004 | Proc Natl Acad Sci USA2004，101，： | 1 |
| 10 | Health risks of heavy metals to the general public in Tianjin, China via consumption of vegetables and fish显示文摘 | Wang X L Sato T Xing B S | 2005 | Science of the Total Environment2005，350，13： | 1 |
| 11 | Distribution and character-ization of integrons in various serogroups of Vibrio cholerae strains isolated from diarrhoeal patients between 1992 and 2000 in Kolkata,India显示文摘 | Shi L Fujihara K Sato T | 2006 | Journal of Medical Microbiology2006，55，5： | 1 |
| 12 | Health risks of heavy metalsto the general public in Tianjin, China via consumption ofvegetables and fish 显示文摘 | WANG X L SATO T XING B S | 2005 | Sci Total Environ2005，350，123： | 1 |
| 13 | Experimental Study on the Interface Fracture Toughness of PVB ( Polyvinyl Butyral)/Glass at High Strain Rates 显示文摘 | Iwasaki R Sato C Lataillade J L | 2007 | International Journal of Crashworthiness2007，12，3： | 1 |
| 14 | Health risks of heavy metals to the general public in Tianjin, China via consumption of vegetables and fish显示文摘 | Wang X L Sato T Xing B S | 2005 | Science of the Total Environment2005，350，： | 1 |
| 15 | Health risks of heavy metals to the general public in Tianjin, China via consumption of vegetables and fish 显示文摘 | Wang X L Sato T Xing B S | 2005 | Science of the Total Environment2005，350，： | 1 |
| 16 | Teriparatide[PTH(1-34)]strengthens the proximal femur of ovariectomized nonhuman primates despite increasing porosity显示文摘 | Sato M Westmore M Yanfei L Ma | | 0，，： | 1 |
| 17 | Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone(I-34) for 2 years and relevance to human safety显示文摘 | Vahle J L Sato M Long G G | 2002 | Toxicol Pathol2002，30，3： | 1 |
| 18 | Combustibility of dried sewage sludge and its mineral transformation at different oxygen content in drop tube furnace显示文摘 | Zhang L Ito M Sato A | 2004 | Fuel Processing Technology2004，85，810： | 1 |
| 19 | Thermodynamic property representation for the R32/125 binary system by a new cubic equation of state显示文摘 | Zhang H L Sato H Watanabe K | 1997 | Int J Refrig1997，20，6： | 1 |
| 20 | 查看详情显示文摘 | Fang Z Sato T Smith R L J Inomata H Arai K Kozinski J A | | 0，，09： | 1 |
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