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| 1 | Prevalence of Malnutrition and Frailty in Elderly Cancer Patients and Resulting Impact on Primary Treatment Recommendations in Colorectal and Breast Cancer显示文摘Objectives To estimate the prevalence of malnutrition in elderly cancer patients and its association with frailty and primary cancer treatment recommendations in patients with the two most prevalent cancers(colorectal cancer,CRC and breast cancer,BC)in the Centre-Val de Loire region of France.Methods The entire cohort of 704 patients aged 75 years or older presenting with cancer who underwent comprehensive geriatric assessment(CGA)between 2014 and 2017 was included.Nutritional status,frailty(defined by the Balducci classification system based on CGA parameters and comorbidity),and pathological criteria were analyzed in terms of the cancer treatment recommendations suggested by geriatricians both in the whole cohort and in those with CRC and BC.Results In the whole group of 704 patients(84.3+/-4.8 years),the prevalence of malnutrition was 62.9%,and was higher in CRC than in BC patients(71.1%vs 55.4%,P<0.01).In a multivariate analysis,malnutrition and frailty(as determined by the Balducci classification system)were independently related in CRC patients(OR:7.28,95%CI,1.58~34.03;P=0.012)and were unrelated to metastasis[odds ratio(OR):1.34,95%CI,0.56~3.18;P=0.5].By contrast,malnutrition in BC patients was related exclusively to the extent of metastasis(OR:3.52,95%CI,1.50~8.24;P=0.002).It was also demonstrated that geriatricians had a greater tendency to suggest only palliative care to CRC patients presenting with malnutrition(15.4%vs 2.7%,P=0.006)than to BC patients(9.8%vs 5.4%,NS).Conclusion Malnutrition in elderly cancer patients is prevalent,especially in those with colorectal cancer,where malnutrition is frailty-related and may strongly impact on cancer treatment strategies. | Vittoria Balzano Véronique Dardaine Giraud Carine Sauger Carole Lefebvre Patrick Heitzmann Thierry Lecomtef Étienne Dorvalg | 2020 | Journal of Nutritional Oncology2020，5，4： | 2 |
| 2 | Tfibologically transformed structure in fretting 显示文摘 | E Sauger S Fouvry L Ponsonnet | 2000 | Wear2000，245，： | 1 |
| 3 | Study of the tribologically transformed structure created during fretting tests 显示文摘 | E Sauger L Ponsonnet J M Martin | 2000 | Tfibology International2000，33，： | 1 |
| 4 | Nucleation and early growth of tribologically transformed structure (TTS) induced by fretting显示文摘 | Zhou Z R Sauger E Liu J J | 1997 | Wear1997，212，： | 1 |
| 5 | Nucleation and early growth of tribologicalIy transformed structure (TTS) induced by fretting显示文摘 | Zhou Z R Sauger E Liu J J | 1997 | Wear1997，212，1： | 1 |
| 6 | Gastric mucosal acidosis and cytokine release in patients with septic shock显示文摘 | Tamion F Richard V Sauger F | 2003 | Crit Care Med2003，31，8： | 1 |
| 7 | Tribologically Transformed Structure in Fretting 显示文摘 | Sauger E Fouvry S Ponsonnet L | 2000 | Wear2000，245，： | 1 |
| 8 | Study of the Tribologically Transformed Structure Created during Fretting Tests 显示文摘 | Sauger E Ponsonnet L Martin J M | 2000 | Tribology International2000，33，： | 1 |
| 9 | Existence d′alpha-fetoprotein au cours d′un cancer secondaire dufoie d'origin gastrique显示文摘 | Bourreille J Metayer P Sauger F | 1970 | Press Med1970，78，28： | 1 |
| 10 | Study of the tribologically transformed structure created during fretting tests 显示文摘 | Sauger E Ponsonnet L Martin J M | 2000 | Tribology International2000，33，： | 1 |
| 11 | Gastric mucos',d acidosis and eytokine release in patients with septic shock显示文摘 | Fabienne Tamion Vincent Richard Francoise Sauger | 2003 | Crit Care Med2003，31，： | 1 |
| 12 | Nucleation and early growth of tribologically transformed structure(TTS)induced by fretting显示文摘 | ZHOU Z R SAUGER E LIU J J VINCENT L | 1997 | Wear1997，212，： | 1 |
| 13 | The cultural representation of the farming landscape:masculinity,power and nature显示文摘 | Saugeres Li | 2002 | Journal of Rural Studies2002，18，6： | 1 |
| 14 | Tribologically transformed structure in fretting显示文摘 | Sauger E Fouvry S Ponsonnet L | 2000 | Wear2000，，245： | 1 |
| 15 | Tribologically transformed structure in fretting显示文摘 | Sauger E Fouvry S Ponsonnet L | 2000 | Wear2000，245，： | 1 |
| 16 | Study of the tribologically transformed structure created during fretting tests显示文摘 | Sauger E Ponsonnet L Martin J M | 2000 | Tribology International2000，，33： | 1 |
| 17 | Study of the tribologically transformed structure created during fretting tests显示文摘 | Sauger E Ponsonnet L Martin J M | 2000 | Tribology International2000，33，： | 1 |
| 18 | Study of the tribologically transformed structure created during fretting tests显示文摘 | SAUGER E PONSONNET L MARTIN J M | 2000 | Tribology International2000，33，11： | 1 |
| 19 | Existence of alphafe- to protein during gastric-origin secondary cancer of the liver 显示文摘 | Bourreille J Metayer P Sauger F | 1970 | Presse Med1970，78，28： | 1 |
| 20 | Tribologically transformed structure in fretting显示文摘 | Sauger E Fouvry S Ponsonnet L | 2000 | Wear2000，245，1： | 1 |
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