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| 1 | Double-balloon enteroscopy-assisted dilatation avoids surgery for small bowel strictures: A systematic review显示文摘AIM To evaluate the therapeutic role of double-balloon enteroscopy(DBE) in small bowel strictures and to propose a standard approach to small bowel strictures.METHODS Systematic review of studies involving DBE in patients with small bowel strictures. Only studies limited to small bowel strictures were included and those with ileo-colonic strictures were excluded. RESULTS In total 13 studies were included,in which 310 patients were dilated. The average follow-up time was 31.8 mo per patient. The complication rate was 4.8% per patient and 2.6% per dilatation. Surgery was avoided in 80% of patients. After the first dilatation,46% were treated with re-dilatation and only 17% required surgery.CONCLUSION DBE-assisted dilatation avoids surgery in 80% of patients with small bowel strictures and is safe and effective. We propose a standardized approach to small bowel strictures. | Judith E Baars Ruben Theyventhiran Patrick Aepli Payal Saxena Arthur J Kaffes | 2017 | World Journal of Gastroenterology2017，23，45： | 6 |
| 2 | Oral microbiota and host innate immune response in bisphosphonate-related osteonecrosis of the jaw显示文摘Bacterial biofilms have emerged as potential critical triggers in the pathogenesis of bisphosphonate(BP)-related osteonecrosis of the jaw(ONJ) or BRONJ. BRONJ lesions have shown to be heavily colonized by oral bacteria, most of these difficult to cultivate and presents many clinical challenges. The purpose of this study was to characterize the bacterial diversity in BRONJ lesions and to determine host immune response. We examined tissue specimens from three cohorts(n530); patients with periodontal disease without a history of BP therapy(Control, n510), patients with periodontal disease having history of BP therapy but without ONJ(BP, n55) and patients with BRONJ(BRONJ, n515). Denaturing gradient gel electrophoresis of polymerase chain reaction(PCR)-amplified 16 S r RNA gene fragments revealed less bacterial diversity in BRONJ than BP and Control cohorts. Sequence analysis detected six phyla with predominant affiliation to Firmicutes in BRONJ(71.6%), BP(70.3%) and Control(59.1%). Significant differences(P,0.05) in genera were observed, between Control/BP, Control/BRONJ and BP/BRONJ cohorts. Enzyme-linked immunosorbent assay(ELISA)results indicated that the levels of myeloperoxidase were significantly lower, whereas interleukin-6 and tumor necrosis factor-alpha levels were moderately elevated in BRONJ patients as compared to Controls. PCR array showed significant changes in BRONJ patients with downregulation of host genes, such as nucleotide-binding oligomerization domain containing protein 2, and cathepsin G, the key modulators for antibacterial response and upregulation of secretory leukocyte protease inhibitor, proteinase 3 and conserved helix–loop–helix ubiquitous kinase. The results suggest that colonization of unique bacterial communities coupled with deficient innate immune response is likely to impact the pathogenesis of ONJ. | Smruti Pushalkar Xin Li Zoya Kurago Lalitha V Ramanathapuram Satoko Matsumura Kenneth E Fleisher Robert Glickman Wenbo Yan Yihong Li Deepak Saxena | 2014 | International Journal of Oral Science2014，6，4： | 4 |
| 3 | ,Concentration and Composition of Atmospheric Aerosols from the 1995 SEVAS Experiment and A Review of the Closure between Chemical and Gravimetric Measurements 显示文摘 | Andrews E Saxena P Musarra S | 2000 | JAWMA2000，50，： | 2 |
| 4 | Parameters of Integral Circulant Graphs and Periodic Quantum Dynamics显示文摘 | Saxena N Severini S Shparlinski I E | 2007 | International Journal of Quantum Information2007，5，3： | 1 |
| 5 | Meta-analysis of genomewide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes显示文摘 | Zeggini E Scott LJ Saxena R | 2008 | Nat Genet2008，40，： | 1 |
| 6 | Risk of early death and recurrent stroke and effect of heparin in 3169 patients with acute ischaemic stroke and atrial fibrillation in the International Stroke Trial显示文摘 | Saxena R Lewis S Berge E | 2001 | Stroke2001，32，： | 1 |
| 7 | Nonlinear-least-squares analysis of slow-motion EPR spectra in one and two dimensions using a modified Levenberg-Marquardt algorithm显示文摘 | Budil D E Lee S Saxena S | 1996 | J Magn Reson Ser A1996，120，2： | 1 |
| 8 | Firsttrimester PAPP-A levels correlate with sFlt-1 levelslongitudinally in pregnant women with and without preeclampsia显示文摘 | Saxena A R Seely E W Rich-Edwards J W | 2013 | BMC Pregnancy Childbirth2013，13，4： | 1 |
| 9 | Nanocarrier-mediated inhibition of macrophage migration inhibitory factor attenuates secondary injury after spinal cord injury显示文摘 | Saxena T Loomis KH Pai S Gaupp E Patil K Patkar R | 2015 | ACS Nano2015，9，2： | 1 |
| 10 | Control-Flow Checking Using Watchdog Assists and Extended-Precision Checksums显示文摘 | Saxena N R McCluskey E J | 1990 | IEEE Trans on Computers1990，39，4： | 1 |
| 11 | Measuring and simulating particulate organics in the atmosphere:problems and prospects显示文摘 | TURPIN B J SAXENA P ANDREWS E | 2000 | Atmospheric Environment2000，34，18： | 1 |
| 12 | 查看详情显示文摘 | Singh A K Liermann H P Akahama Y Saxena S K Menendez-Proupin E | | 0，，： | 1 |
| 13 | Approximate formula for the thermal conductivity of gas mixtures显示文摘 | Mason E A Saxena S C | 1958 | Physics of Fluids1958，5，1： | 1 |
| 14 | Meta'analysis of genome, wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes 显示文摘 | Zeggini E Scott LJ Saxena R | 2008 | Nat Genet2008，40，7： | 1 |
| 15 | Does preoperative atrial fibrillation portend a poorer prognosis in patients undergoing isolated aortic valve replacement- A multicentre Australian study显示文摘 | Saxena A Dinh D T Reid C M Smith J A Shardey G C Newcomb A E | 2013 | Can J Cardiol2013，29，： | 1 |
| 16 | Adiponectin deficiency:role in chronic inflammation induced colon cancer显示文摘 | Saxena A Chumanevich A Fletcher E | 2012 | Biochimica etbiophysica acta2012，1822，4： | 1 |
| 17 | Measuring and simulating particulate organics in the atmosphere: Problems and prospects显示文摘 | Turpin B J Saxena P Andrews E | 2000 | Atmospheric Environment2000，34，18： | 1 |
| 18 | Chlorchimaphilin:Anew antibiotic from Moneses unif olora显示文摘 | Saxena G Farmer S W Hancock R E | 1996 | J Nat Prod1996，59，1： | 1 |
| 19 | Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes显示文摘 | Zeggini E Scott LJ Saxena R | 2008 | Nat Genet2008，40，5： | 1 |
| 20 | Stromal cell dcrived factor-1 is cardioprotective after myocardial infarction显示文摘 | Saxena A Fish J E Whitc M D | | 0，，： | 1 |
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