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| 1 | Systematic review and meta-analysis on the prophylactic role of non-steroidal anti-inflammatory drugs to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis显示文摘AIM: To critically appraise the published randomized, controlled trials on the prophylactic effectiveness of the non-steroidal anti-inflammatory drugs(NSAIDs), in reducing the risk of post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis. METHODS: A systematic literature search(MEDLINE, Embase and the Cochrane Library, from inception of the databases until May 2015) was conducted to identify randomized, clinical trials investigating the role of NSAIDs in reducing the risk of post-ERCP pancreatitis. Random effects model of the meta-analysis was carried out, and results were presented as odds ratios(OR) with corresponding 95%CI.RESULTS: Thirteen randomized controlled trials on 3378 patients were included in the final meta-analysis. There were 1718 patients in the NSAIDs group and 1660 patients in non-NSAIDs group undergoing ERCP. The use of NSAIDs(through rectal route or intramuscular route) was associated with the reduced risk of post-ERCP pancreatitis [OR, 0.52(0.38-0.72), P = 0.0001]. The use of pre-procedure NSAIDs was effective in reducing approximately 48% incidence of post-ERCP pancreatitis, number needed to treat were 16 with absolute risk reduction of 0.05. But the risk of post-ERCP pancreattis was reduced by 55% if NSAIDs were administered after procedure. Similarly, diclofenac was more effective(55%) prophylactic agent compared to indomethacin(41%).CONCLUSION: NSAIDs seem to have clinically proven advantage of reducing the risk of post-ERCP pancreatitis. | Muhammad S Sajid Amir H Khawaja Mazin Sayegh Krishna K Singh Zinu Philipose | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，19： | 14 |
| 2 | Rock/ fluid interactions of carbonated brines in a sandstone reservoir Pembina Cardium, Alberta, Canada显示文摘 | Sayegh S G Krause F F Girard Marcel | 1990 | SPE Formation Evaluation1990，5，4： | 1 |
| 3 | Gene type classification of colorectal adenocarcinoma biologic behavior correlates with k-ras-2 muta- tion type显示文摘 | Finkelstein SD Sayegh R Christensen S | 1993 | Cancer1993，71，： | 1 |
| 4 | Laboratory evaluation of the CO2 Huff-N-Puff process for heavy oil-reservoirs 显示文摘 | Sayegh S G Maini B B | 1984 | Journal of Canadian Petroleum Technology1984，23，3： | 1 |
| 5 | Acquired thymic tolerance: role of CTLA4 in the initiation and maintenance of tolerance in a clinically relevant autoimmune disease model显示文摘 | Issazadeh S Zhang M Sayegh MH | 1999 | J Immunol1999，162，2： | 1 |
| 6 | Genetype ciassification of colorectal adenocarcinoma biologic behavior correlates with K- ras-2 mutation type显示文摘 | Finkelstein S D Sayegh R Christensen S | 1993 | Cancer1993，71，： | 1 |
| 7 | Maini laboratory evaluation of the CO2huff-n-puff process for heavy oil reservoirs显示文摘 | Sayegh S G | 1984 | Journal of Canadian Petroleum Technology1984，23，2： | 1 |
| 8 | Acquired thymic tolerance:role of CTLA-4 in the initiation and maintenance of tolerance in a clinically relevant autoimmune disease model显示文摘 | Issazadeh S Zhang M Sayegh MH | 1999 | J Immunol1999，162，2： | 1 |
| 9 | Role of embolisation in the treatment of bronchopulmonary sequestration显示文摘 | Curros F Chigot V Emond S Sayegh N Revillon Y Scheinman P | | 0，，： | 1 |
| 10 | TNM and Japanese Staging Systems for Gastric Cancer:How do they Coexist?显示文摘 | Sayegh ME Sano T Dexter S | 2004 | Gastric Cancer2004，7，3： | 1 |
| 11 | The Boston keratoprosthesis in Stevens-Johnson syndrome 显示文摘 | Sayegh R R Ang L P Foster C S | 2008 | Am J Ophthalmol2008，145，3： | 1 |
| 12 | Risk assessment and allocation in the UAE construction industry 显示文摘 | EL -SAYEGH S M | 2008 | International Journal of Project Manage- merit2008，26，4： | 1 |
| 13 | Blocking costimulatory signals to induce transplantation tolerance and prevent autoimmune disease显示文摘 | Sayegh MH Turka LA | 1999 | Int Rev Immunol1999，18，3： | 1 |
| 14 | Acquired thymic tolerance:role of CTLA - 4 in the initiation and maintenance of tolerance in a clinically relevant autoimmune disease model 显示文摘 | Issazadeh S Zhang M Sayegh MH | 1999 | J Immunol1999，162，2： | 1 |
| 15 | Glucocorticoid induction of epi- thelial sodium channel expression in lung and renal epithelia occurs via trans-activation of a hormone response element in the 5' -flanking region of the human epithelial sodium channel alpha subunit gene显示文摘 | Sayegh R Auerbach S D Li X | 1999 | J Biol Chem1999，274，12： | 1 |
| 16 | Ac- quired thymic tolerance : role of CTLA - 4 in the initiation and maintenance of tolerance in a clinically relevant autoimmune disease model 显示文摘 | Issazadeh S Zhang M Sayegh MH | 1999 | Immunol1999，162，2： | 1 |
| 17 | Reductions of errors of microphotographic reproductions by optical corrections of original masks 显示文摘 | Saleh B E A Sayegh S I | 1981 | Optical Engineering1981，20，5： | 1 |
| 18 | Intussusception in infants and children: feasibility of ambulatory management显示文摘 | Masne A L Lortat-Jacob S Sayegh N | 1999 | Eur J Pediatr1999，158，9： | 1 |
| 19 | TNM and Japanese staging systems for gastric cancer: how do they coexist 显示文摘 | Sayegh ME Sano T Dexter S | 2004 | Gastric Cancer2004，7，4： | 1 |
| 20 | The roles of the new negative T cell costimulatory pathways in regulating autoimmunity 显示文摘 | Khoury S J Sayegh MH | 2004 | Immunity2004，20，5： | 1 |
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