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| 1 | Acute kidney injury and post-reperfusion syndrome in liver transplantation显示文摘In the past decades liver transplantation(LT) has become the treatment of choice for patients with end stage liver disease(ESLD). The chronic shortage of cadaveric organs for transplantation led to the utilization of a greater number of marginal donors such as older donors or donors after circulatory death(DCD). The improved survival of transplanted patients has increased the frequency of long-term complications, in particular chronic kidney disease(CKD). Acute kidney injury(AKI) post-LT has been recently recognized as an important risk factor for the occurrence of denovo CKD in the long-term outcome. The onset of AKI post-LT is multifactorial, with pre-LT risk factors involved, including higher Model for End-stage Liver Disease score, more sever ESLD and pre-existing renal dysfunction, either with intra-operative conditions, in particular ischaemia reperfusion injury responsible for post-reperfusion syndrome(PRS) that can influence recipient's morbidity and mortality. Post-reperfusion syndrome-induced AKI is an important complication post-LT that characterizes kidney involvement caused by PRS with mechanisms not clearly understood and implication on graft and patient survival. Since preLT risk factors may influence intra-operative events responsible for PRS-induced AKI, we aim to consider all the relevant aspects involved in PRS-induced AKI in the setting of LT and to identify all studies that better clarified the specific mechanisms linking PRS and AKI. A Pub Med search was conducted using the terms liver transplantation AND acute kidney injury; liver transplantation AND post-reperfusion syndrome; acute kidney injury AND post-reperfusion syndrome; acute kidney injury AND DCD AND liver transplantation. Five hundred seventy four articles were retrieved on Pub Med search. Results were limited to title/abstract of English-language articles published between 2000 and 2015. Twenty-three studies were identified that specifically evaluated incidence, risk factors and outcome for patients developing PRS-induced AKI in liver transplantation. In order to identify intra-operative risk factors/mechanisms specifically involved in PRSinduced AKI, avoiding confounding factors, we have limited our study to 'acute kidney injury AND DCD AND liver transplantation'. Accordingly, three out of five studies were selected for our purpose. | Ilaria Umbro Francesca Tinti Irene Scalera Felicity Evison Bridget Gunson Adnan Sharif James Ferguson Paolo Muiesan Anna Paola Mitterhofer | 2016 | World Journal of Gastroenterology2016，22，42： | 16 |
| 2 | Liver-spleen axis: Intersection between immunity, infections and metabolism显示文摘Spleen has been considered a neglected organ so far, even though is strictly linked to liver. The spleen plays an important role in the modulation of the immune system and in the maintenance of peripheral tolerance via the clearance of circulating apoptotic cells, the differentiation and activation of T and B cells and production of antibodies in the white pulp. Moreover, splenic macrophages are able to remove bacteria from the blood and protect from sepsis during systemic infections. We review the spleen function and its assessment in humans starting from the description of spleen diseases, ranging from the congenital asplenia to secondary hyposplenism. From the literature data it is clear that obesity in humans affects different compartments of immune system, even thought there are still few data available on the implicated mechamisms. The intent is to enable clinicians to evaluate the newly recognized role of metabolic and endocrine functions of the spleen with special emphasis to obesity and nonalcoholic fatty liver disease in the context of the available literature.Moreover, understanding the spleen function could be important to develop appropriate prevention strategies in order to counteract the pandemia of obesity. In this direction, we suggest spleen longitudinal diameter at ultrasonography, as simple, cheap and largely available tool, be used as new marker for assessing splenic function, in the context of the so-called liver-spleen axis. | Giovanni Tarantino Antonella Scalera Carmine Finelli | 2013 | World Journal of Gastroenterology2013，19，23： | 13 |
| 3 | What does irritable bowel syndrome share with non-alcoholic fatty liver disease?显示文摘Non-alcoholic fatty liver disease(NAFLD)and irritable bowel syndrome(IBS)are two very common diseases in the general population.To date,there are no studies that highlight a direct link between NAFLD and IBS,but some recent reports have found an interesting correlation between obesity and IBS.A systematic PubMed database search was conducted highlighting that common mechanisms are involved in many of the local and systemic manifestations of NAFLD,leading to an increased cardiovascular risk,and IBS,leading to microbial dysbiosis,impaired intestinal barrier and altered intestinal motility.It is not known when considering local and systemic inflammation/immune system activation,which one has greater importance in NAFLD and IBS pathogenesis.Also,the nervous system is implicated.In fact,inflammation participates in the development of mood disorders,such as anxiety and depression,characteristics of obesity and consequently of NAFLD and,on the other hand,in intestinal hypersensitivity and dysmotility. | Antonella Scalera Matteo Nicola Dario Di Minno Giovanni Tarantino | 2013 | World Journal of Gastroenterology2013，19，33： | 3 |
| 4 | The first pandemic of the 21st century:a review of the 2009 pandemic variant influenza A (H1N1) virus显示文摘 | Scalera NM Mossad SB | 2009 | Postgrad Med2009，121，5： | 1 |
| 5 | Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl L-arginine accelerates endothelial cell senescence 显示文摘 | Scalera F Bodak J Beckmann B | 2004 | Arterioscler Thromb Vasc Biol2004，24，： | 1 |
| 6 | Treatment persis-tence and compliance with medications for chronic obstructivepulmonary disease显示文摘 | Cramer JA Bradley-Kennedy C Scalera A | 2007 | Can Respir J2007，14，1： | 1 |
| 7 | Asymmetric dimethylarginine (ADMA) accelerates cell senescence 显示文摘 | Bode-Boger SM Scalera F Martens-Lobenhoffer J | 2005 | Vasc Med2005，10，1： | 1 |
| 8 | Asynunetric dimethylarginine (ADMA) accelerates cell senescence显示文摘 | Bode-Poger SM Scalera F Martens-Lobenhoffer J | 2005 | Vasc Med2005，10，1： | 1 |
| 9 | Traumatic focal pancreatitis with ret?ro-duodenal hematoma: a rare cause of combined biliary and gastric outlet obstruction显示文摘 | Scalera I Kumar S Bramhall S | 2012 | JOP2012，13，6： | 1 |
| 10 | The first pandemic of the 21st century: a review of the 2009 pandemic variant influenza A (H1N1) virus 显示文摘 | Scalera NM Mossad SB | 2009 | Postgradute Med2009，121，5： | 1 |
| 11 | Novel superabsorbent cellulose-based hydrogels crosslinked with citric acid显示文摘 | Christian Demitri Roberta Del Sole Francesca Scalera | 2008 | Applied Polymer Science2008，110，4： | 1 |
| 12 | Quantitative MR imaging:physical principles and sequence design in abdominal imaging 显示文摘 | Shah B Anderson SW Scalera J | 2011 | Radiographics2011，3，： | 1 |
| 13 | Development and characterization of UV curable epoxy/hydroxyapatite suspensions for stereolithography applied to bone tissue engineering 显示文摘 | Scalera F Corcione C E Montagna F Sannino A Maffez- zoli A | 2014 | Ceramics Interna- tional2014，40，15： | 1 |
| 14 | Peptides that regulate food intake Somatostatin alters intake of amino acid-inbalaneed diets and taste buds of tongue in rats 显示文摘 | Scalera G | 2003 | American Journal of Physiology Regulation Integral Comperative Physioloey2003，284，6： | 1 |
| 15 | Group reputation and persistent discrimination in credit markets 显示文摘 | Scalera Domenico Zazzaro Alberto | 2001 | Journal of Multinational Financi Management Elsevier2001，，11： | 1 |
| 16 | Endogenous nitric oxide synthesis inhibitor asymmetric dimetlyl L-arginine accelerates endothelial cell senescence 显示文摘 | Scalera F Borlak J Beckmann B | 2004 | Arterioscler Thromb Vasc Biol2004，24，10： | 1 |
| 17 | Erythropoietin increases asymmetric dimethylarginine in endothelial cells:role of dimethylarginine dimethylaminohydrolase显示文摘 | Scalera F Kielstein J T Martens-lobenhoffer J | 2005 | J Am Soc Nephrol2005，16，： | 1 |
| 18 | Stent placement in patients with coronary heart disease dacmascs plasma levels of the endogenous nitric oxide synthasc inhibitor ADMA显示文摘 | Ajtay Z Scalera F Czirllki A | 2009 | Int J Mol Mcd2009，23，5： | 1 |
| 19 | Effect of L-arginine on asymmetric dimethylarginine (ADMA) or homocysteine-accelerated endothelial cell aging 显示文摘 | Scalera F Martens-Lobenhoffer J Tager M | 2006 | Biochem Biophys Res Commun2006，345，3： | 1 |
| 20 | Influence of the flavonolignan silybinin of milk thistle on hepatocytes and kidney cells 显示文摘 | SONNENBICHLER J SONNENBICHLER I SCALERA F | 1998 | ACS Symposium Series1998，691，： | 1 |
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