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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
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| 3 | Credit assigned CMAC and it's application to online learning robust controllers 显示文摘 | Su SF Ted T Hung T H | 2003 | IEEE Transactions on Systems Man and Cybernetics-Part B: Cybernetics2003，33，2： | 1 |
| 4 | Hemodynamic determinants of the mitral annulus diastolic velocities by tissue Doppler显示文摘 | Nagueh SF Sun H Kopelen HA | 2001 | J Am Coll Cardiol2001，37，1： | 1 |
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| 7 | The role of extracellular signalregulated kinase/mitogen-activated protein kinase pathway in multidrug resistance ofhepatocellular carcinoma显示文摘 | Zhu H Chen XP Luo SF | | 0，，13： | 1 |
| 8 | Fusarium root rot of eoneflower seedlings and integrated control using Trichoderma and fuagicides显示文摘 | Wang H Chang KF Hwang SF | 2005 | BioControl2005，50，2： | 1 |
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| 14 | Thoracic empyema: cur-rent opinions in medical and surgical management显示文摘 | Lee SF Lawrence D Booth H | 2010 | Curr Opin Pulm Med2010，16，： | 1 |
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| 17 | Impact of unilateral interposition sural nerve grafting on recovery of urinary function af?ter radical prostatectomy显示文摘 | Singh H Karakiewicz P Shariat SF | 2004 | Urology2004，63，6： | 1 |
| 18 | Combining ability for grain chemistry quality traits in a white oat dial- lelic cross显示文摘 | Crestani M Silveira Silveira SF Tessmann EW Mezzalira I Souza Luche H Silva JAG Gutkoski LC Carvalho FIF Oliveira AC | 2012 | Euphytica2012，185，1： | 1 |
| 19 | Anti-TIM-3 antibody promotes T cell IFN-g-mediated antitumor immunity and suppresses established tumors显示文摘 | Ngiow SF Scheidt B Akiba H | | 0，，10： | 1 |
| 20 | Anti-TIM3 antibody pmmotes T cell IFN-γ-mediated anti-tumor immunity and suppresses established tumors显示文摘 | Ngiow SF von Scheidt B Akiba H | 2011 | Cancer Res2011，71，10： | 1 |
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