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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | Effect of human skin-derived stem cells on vessel architecture, tumor growth, and tumor invasion in brain tumor animal models显示文摘 | Pisati F Belicchi M Acerbi F Marchesi C Giussani C Gavina M Javerzat S Hagedorn M Carrabba G Lucini V Gaini SM Bresolin N Bello L Bikfalvi A Torrente Y | 2007 | 中国神经肿瘤杂志2007，5，2： | 10 |
| 3 | 静脉血栓栓塞症的抗血栓治疗:美国《胸科学》杂志指南显示文摘包括深静脉血栓和肺栓塞在内的静脉血栓栓塞症是癌症患者的主要并发症,发生率为4%~20%,并且是常见的潜在致命性急症。本文介绍了美国《胸科学》杂志指南中VET的抗血栓治疗的部分内容,其以第9版《美国胸内科医师学会循证临床实践指南》中的《静脉血栓栓塞症的抗血栓治疗:抗血栓治疗和阻止血栓形成》一文为参照,基于静脉血栓栓塞症治疗的Ⅲ期试验的发表年份,对口服抗凝剂(达比加群、利伐沙班、阿哌沙班、依度沙班)进行先后阐述(但是这一排序并不是指南专家组对药剂的优劣排序),以为临床医生提供参考。 | Kearon C Akl EA Ornelas J Blaivas A Jimenez D Bounameaux H Huisman M King CS MorrisT Sood N Stevens SM Vintch JRE Wells P Woller SC Moores CL 本刊编辑部 | 2016 | 中国全科医学2016，19，9： | 10 |
| 4 | 酒精摄入、心脏生物标志物和心房颤动风险与不良结局显示文摘酒精摄入和新发心房颤动相关性证据不一,尤其是在低剂量下。该研究评估欧洲队列在整个饮酒范围内酒精摄入、生物标志物和新发心房颤动的关系。方法和结果:在一个以社区为基础的汇集队列中,研究者随访107845人,以评估酒精摄入(酒精种类和饮酒方式)与新发心房颤动的关系。研究者收集经典心血管病危险因素和新发心力衰竭的信息,并检测生物标记物氨基末端脑钠肽前体和高敏肌钙蛋白I。 | 陈嘉睿(译) 练桂丽((审校) Csengeri D Sprünker NA Di Castelnuovo A Niiranen T Vishram-Nielsen JK Costanzo S S derberg S Jensen SM Vartiainen E Donati MB Magnussen C Camen S Gianfagna F L chen ML Kee F Kontto J Mathiesen EB Koenig W Stefan B de Gaetano G J rgensen T Kuulasmaa K Zeller T Salomaa V Iacoviello L Schnabel RB | 2021 | 中华高血压杂志2021，29，2： | 9 |
| 5 | 巴氏腺囊肿显示文摘Key facts Definition:Cystic dilation of Bartholin′s gland.Bartholin′s glands are bilateral mucin-secreting gland lying on posterolateral aspect of vulvar vestibule.Classic imaging appearance is round,well-defined,unilocular cyst lying at posterior aspect of vulva.Bartholin′s gland may also give rise to abscesses,tumors,and cysts.Bartholin′s gland cysts are not commonly bilateral. | Hricak H Reinhold C Ascher SM 关键 | 2015 | 影像诊断与介入放射学2015，24，4： | 4 |
| 6 | Pain management in mice using methanol extracts of three plants belongs to family Amaranthaceae显示文摘Objective:To investigate the analgesic activity of methanolic extract of Amaranthus viridis(A. viridis),Amaranthus caudatus(A.caudatus) and Amaranthus spinosus(A.spinosus).Methods:In this study,the analgesic activity of methanol extracts of all three plants at doses of 200 and 400 mg/kg were investigated by acetic acid-induced writhings test,hot plate test and tail immersion test for mice.Results:It was found that all the three plants showed significant pain management effect(P<0.01) at a dose of 400 mg/kg,but showed a less significant effect at a dose of 20 mg/kg in the entire tests used for evaluation of analgesic activities(P<0.05).Conclusions:Methanol extracts of A.viridis,A.caudatus and A.spinosus show potent analgesic activities,and this study provides the scientific proof for their traditional claims. | Ashok Kumar BS Lakshman K Jayaveera KN Vel Murgan C Arun Kumar PA Vinod Kumar R Meghda Hegade Sridhar SM | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，7： | 2 |
| 7 | A new type I IFN-mediated pathway for the rapid differentiation of monocytes into highly active dendritic cells显示文摘 | Di Pucchio T Lapenta C | 2003 | Stem Cells2003，21，3： | 1 |
| 8 | Homocysteine, 5, 10 methylenetetrahydrofolate reductase 677C>T polymorphism, nutrient intake, and incident cardiovascular disease in 24 968 initially healthy women显示文摘 | Robert YL Zee SM Suzanne C | 2007 | Clinical Chemistry2007，53，10： | 1 |
| 9 | The need to know: Informal earers and information显示文摘 | Morris SM Thomas C | 2002 | Cancer2002，11，3： | 1 |
| 10 | Vector specificity of barley yellow dwarf virus(BYDV) transmission: identification of potential cellular receptors binding BYDV-MAV in the aphid, Sitobion avenae显示文摘 | Li C Cox-Foster D Gray SM | 2001 | Virology2001，286，： | 1 |
| 11 | NAD(P)H:Quinone oxidoreductase activity is the principal determinant of β-lapachone cytotoxicity显示文摘 | Pink JJ Planchon SM Tagliarino C | 2000 | J Biol Chem2000，275，8： | 1 |
| 12 | LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis显示文摘 | Mouta Carreira C Nasser SM di Tomaso E et al | 2001 | Cancer Res2001，61，22： | 1 |
| 13 | Effect of chronic coatiministration of endotoxin and,ethanol on rat liver pathology and proinflammatory and anti-inflammatory cytokines 显示文摘 | Jarvelainen HA Fang C Ingelman SM | 1999 | Hepatology1999，29，5： | 1 |
| 14 | Leptin is suppressed during infusion ofrecombinant human insulin-like growth factor 1(rhlGF-1) in nor-mal rats显示文摘 | Boni SM Hauri C Zapf J | 1999 | Diabetologia1999，42，： | 1 |
| 15 | LYVE-1 is not restricted to the lymphatic vessel:expression in normal liver blood sinusoids and down-regulation in human liver comer and cirrhosis显示文摘 | Mouta-Carreira C Nasser SM | 2001 | Cancer Res2001，61，22： | 1 |
| 16 | Methodology of clinical trials focusing on the PC-Fix clinical trials显示文摘 | Hauke C Meisser A Perren SM | 2001 | Injury2001，32，2： | 1 |
| 17 | Integrated approaches toimprove birth outcomes: perinatal periods of risk,infant mortal-ity review,and the Los Angeles Mommy and Baby Project 显示文摘 | Chao SM Donatoni G?Bemis C | 2010 | Matern Child Health2010，14，6： | 1 |
| 18 | Changes in the incidence and out- come tor early acute kidney injury in a cohort of Australian intensive care units显示文摘 | Bagshaw SM George C Bellomo R | 2007 | Crit Care2007，11，3： | 1 |
| 19 | Opposing regulation of the locus encoding IL-17 through diroet, reciprocal actions of STAT3 and STATS显示文摘 | Yang XP C horesehi K Steward-11ua-p SM | 2011 | Nat Immunol2011，12，3： | 1 |
| 20 | Head circumference of children with Down syndrome (0-36 months) 显示文摘 | Palmer CG Cronk C Pueschel SM | 1992 | Am J Med Genet1992，42，： | 1 |
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