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| 1 | Evaluation of quantitative contrast harmonic imaging to assess malignancy of liver tumors:A prospective controlled two-center study显示文摘AIM: To establish the extent to which contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics facilitates the detection of hepatic tumors. METHODS: One hundred patients with histologically confirmed malignant or benign hepatic tumor (maximum size 5 cm) were analyzed. Contrast-enhanced ultrasound (bolus injection 2.5 mL SonoVue) was carried out with intermittent breath-holding technique using a multifrequency transducer (2.5-4 MHz). Native vascularization was analyzed with power Doppler. The contrast-enhanced dynamic ultrasound investigation was carried out with contrast harmonic imaging in true detection mode during the arterial,portal venous and late phases. Mechanical index was set at 0.15. Perfusion analysis was performed by post-processing of the raw data time intensity curve (TIC) analysis. The cut-off of the gray value differences between tumor and normal liver tissue was established using Receiver Operating Characteristic (ROC) analysis 64-line multi-slice computed tomography served as reference method in all cases. Magnetic resonance tomography was used additionally in 19 cases. RESULTS: One hundred patients with 59 malignant (43 colon,5 breast,2 endocrine metastases,7 hepatocellular carcinomas and 2 kidney cancers) and 41 benign (15 hemangiomas,7 focal nodular hyperplasias,5 complicated cysts,2 abscesses and 12 circumscribed fatty changes) tumors were included. The late venous phase proved to be the most sensitive for classification of the tumor type. Fifty-eight of the 59 malignant tumors were classified as true positive,and one as false negative. This resulted in a sensitivity of 98.3%. Of the 41 benign tumors,37 were classified as true negative and 4 as false negative,which corresponds to a specificity of 90.2%. Altogether,95.0% of the diagnoses were classified as correct on the basis of the histological classification. No investigator-dependency (P = 0.23) was noted. CONCLUSION: The results show the possibility of accurate prediction of malignancy of hepatic tumors with a positive prognostic value of 93.5% using advanced contrast-enhanced ultrasound. Contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics is a valuable tool to discriminate hepatic tumors. | EM Jung DA Clevert AG Schreyer S Schmitt J Rennert R Kubale S Feuerbach F Jung | 2007 | World Journal of Gastroenterology2007，13，47： | 15 |
| 2 | Comparison of high-resolution ultrasound and MR-enterography in patients with inflammatory bowel disease显示文摘AIM:To compare the results of high-resolution ultrasound(HR-US) and magnetic resonance enterography(MRE) examinations in patients with inflammatory bowel disease(IBD).METHODS:The reports of 250 consecutive cases with known IBD,who had an MRE and HR-US examination,were retrospectively analyzed.Using a patient-based approach we evaluated morphological disease features such as affected bowel wall,stenosis,abscess and fistula.The comparison between the two modalities was based on the hypothesis,that any pathological change described in any imaging modality was a true finding,as no further standard of reference was available for complete assessment.RESULTS:Two hundred and fifty examinations representing 207 different patients were evaluated.Both modalities assessed similar bowel wall changes in 65% of the examinations,with more US findings in 11% and more MRE findings in 15%.When the reports were analyzed with regard to 'bowel wall inflammation',US reported more findings in 2%,while MRE reported more findings in 53%.Stenoses were assessed to be identical in 8%,while US found more in 3% and MRE in 29%(P < 0.01).For abscess detection,US showed more findings in 2%(n = 4) while MRE detected more in 6%(n = 16).US detected more fistulas in 1%(n = 2),while MRE detected more in 13%(n = 32)(P < 0.001).The most common reason for no detected pathology by US was a difficult to assess anatomical region(lesser pelvis,n = 72).CONCLUSION:US can miss clinically relevant pathological changes in patients with IBD mostly due to difficulty in assessing certain anatomical regions. | Andreas G Schreyer Cynthia Menzel Chris Friedrich Florian Poschenrieder Lukas Egger Christian Dornia Gabriela Schill Lena M Dendl Doris Schacherer Christl Girlich Ernst-Michael Jung | 2011 | World Journal of Gastroenterology2011，17，8： | 7 |
| 3 | Dynamic magnetic resonance defecography in 10 asymptomatic volunteers显示文摘AIM: Evaluation of the wide range of normal findings in asymptomatic women undergoing dynamic magnetic resonance (MR) defecography. METHODS: MR defecography of 10 healthy female volunteers (median age: 31 years) without previous pregnancies or history of surgery were evaluated. The rectum was filled with 180 mL gadolinium ultrasound gel mixture. MR defecography was performed in the supine position. The pelvic floor was visualized with a dynamic T2-weighted sagittal plane where all relevant pelvic floor organs were acquired during defecation. The volunteers were instructed to relax and then to perform straining maneuvers to empty the rectum. The pubococcygeal line (PCGL) was used as the line of reference. The movement of pelvic floor organs was measured as the vertical distance to this reference line. Data were recorded in the resting position as well as during the defecation process with maximal straining. Examinations were performed and evaluated by two experienced abdominal radiologists without knowledge of patient history. RESULTS: Average position of the anorectal junction was located at -5.3 mm at rest and -29.9 mm during straining. The anorectal angle widened significantly from 93° at rest to 109° during defecation. A rectocele was diagnosed in eight out of 10 volunteers showing an average diameter of 25.9 mm. The bladder base was located at a position of +23 mm at rest and descended to -8.1 mm during defecation in relation to the PCGL. The bladder base moved below the PCGL in six out of 10 volunteers, which was formally defined as a cystocele. The uterocervical junction was located at an average level of +43.1 mm at rest and at +7.9 mm during straining. The uterocervical junction of three volunteers fell below the PCGL; described formally as uterocervical prolapse. CONCLUSION: Based on the range of standard values in asymptomatic volunteers, MR defecography values for pathological changes have to be re-evaluated. | Andreas G Schreyer Christian Paetzel Alois Fürst Lena M Dendl Elisabeth Hutzel René Müller-Wille Philipp Wiggermann Stephan Schleder Christian Stroszczynski Patrick Hoffstetter | 2012 | World Journal of Gastroenterology2012，18，46： | 7 |
| 4 | MR-arterioportography: A new technical approach for detection of liver lesions显示文摘AIM: To evaluate the benefit and effectiveness of MRarterioportography (MR-AP) to achieve the highest sensitivity for detection and evaluation of hepatocellular carcinoma (HCC). METHODS: Twenty liver cirrhosis patients with suspected HCC were included before transarterial chemoembolization. In all patients double-enhanced Magnetic resonance imaging (MRI) was performed. A bolus of 10 mL Magnevist was injected through a selectively placed catheter in the superior mesenteric artery and MRI of the liver was performed in arterioportographic phase. Two independent readers evaluated number, size and localization of detected lesions. Diagnostic quality was determined using a 4-point scale. Differences were analyzed for significance using a t -test. Interobserver variability was calculated. RESULTS: In all 20 patients (100%), MR-AP was feasible. Diagnostic quality was, in all cases, between 1 and2 for both modalities and readers. MR-AP detected significantly more lesions than double-enhanced MRI (102.5 vs 61, respectively, P < 0.0024). The inter-observer variability was 0.881 for MRI and 0.903 for MR-AP. CONCLUSION: Our study confirmed that the MR-AP as an additional modality for detection of HCC is beneficial, as significantly more lesions were detected compared to MRI with liver-specific contrast. | Janine Rennert Ernst-Michael Jung Andreas G Schreyer Patrick Hoffstetter Peter Heiss Stefan Feuerbach Niels Zorger | 2011 | World Journal of Gastroenterology2011，17，13： | 2 |
| 5 | Helical CT of the urinary organs显示文摘 | Schreyer HH Uggowitzer MM Ruppert-Kohlmayr A | 2002 | Eur Radio2002，12，： | 1 |
| 6 | Helical CT of the urinary organs显示文摘 | Uggowitzer MM Ruppert-Kohlmayr A | 2002 | Eur Radiol2002，12，3： | 1 |
| 7 | Simulation of soil-concrete interfaces with nonlocal constitutive models显示文摘 | CHEN Z SCHREYER H L | 1987 | Journal of Soil Mechanics and Foundation Engineering Division ASCE1987，113，11： | 1 |
| 8 | Preparation and purification of potassium ferrate ( Ⅵ ) 显示文摘 | THOMPSON G W OCKERMAN L T SCHREYER J M | 1951 | Am Chem Soc1951，73，3： | 1 |
| 9 | Effect of regular physical activity on defecation pattern in middle-aged patients complaining of chronic constipation 显示文摘 | De Schreyer AM Kelemans YC Peters HP | 2005 | Scand J Gastroenterology2005，40，4： | 1 |
| 10 | ICT investment and economic growth in the 1990s: is the United States a unique case? - A comparative study of nine OECD countries显示文摘 | Colecchia A Schreyer P | 2002 | Review of Economic Dynamics2002，，5： | 1 |
| 11 | Pb - Sr - Nd Isotopic Behavior of Deeply Subducted Crustal Rocks from the Dora Maira Massif, Western Alps, Italy-I1: What Is the Age of the Ultra-High-Pressure Meta- morphism? 显示文摘 | Tilton G R Schreyer W Schertl H - P | 1991 | Contributions to Mineralogy andPetrollogy1991，108，： | 1 |
| 12 | Simultaneous synthesis of aromatic acid chlorides and metal chlorides显示文摘 | Schreyer R C | 1958 | J Am Chem Soc1958，80，13： | 1 |
| 13 | A particle method for history-dependent materials显示文摘 | Sulsky D Chen Z Schreyer H L | 1994 | Computer Methods in Applied Mechanics and Engineering1994，118，： | 1 |
| 14 | Phengite geobarometry based on the limiting assemblage with K-feldspar, phlogopite, and quartz显示文摘 | Massonne H J Schreyer W | 1987 | Contributions to Mineralogy and Petrology1987，96，： | 1 |
| 15 | Fluid-membrane interaction based on the material point method显示文摘 | Allen R Sulsky D Schreyer H L | 2000 | International Journal for Numerical Methods in Engineering2000，48，： | 1 |
| 16 | A particle method for history-dependent materials显示文摘 | Sulsky D Chen Z Schreyer H L | 1994 | Computer Methods in Applied Mechanics and Engineering1994，118，394041： | 1 |
| 17 | Loss of lymphotoxin α but not tumor necrosis factor-α reduces atherosclerosis in mice 显示文摘 | Schreyer SA Vick CM LeBoeuf RC | 2002 | J Biol Chem2002，277，12： | 1 |
| 18 | Application of a par- ticle-in-cell method to solid mechanics显示文摘 | Sulsky D Zhou S Schreyer H L | 1995 | Computer Physics Communieations1995，87，12： | 1 |
| 19 | Development of neuronal polarity : GAP- 43 distinguishes axonal from dendritic growth cones 显示文摘 | GOSLINS K SCHREYER D J SKENE J H P | 1988 | Nature1988，33，6200： | 1 |
| 20 | Oxidation of Chromium(Ⅲ) with Potassium Ferrate (Ⅵ) 显示文摘 | J M Schreyer G W Thompson L T Ockerman | 1950 | Ana Chem1950，22，11： | 1 |
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