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| 1 | 高龄老年心绞痛患者的介入治疗和外科手术治疗显示文摘目的 评价介入治疗(PCI)和外科手术(CABG)治疗老年(≥80岁)心绞痛患者的有效性和安全性。方法 回顾性分析4年间在莱比锡心脏中心连续就诊的老年心绞痛,接受PCI和CAN3治疗患者。观察终点为住院期间死亡、再次心肌梗死、再次血运重建。结果 共482例患者,分为PCI组281例,CABG组201例。糖尿病、高血压、肥胖症、既往心肌梗死史等在两组间无显著性差异。既往PCI、CABG史者在PCI组更多(20.6% vs 8.0%,P<0.05:10.096 vs 2.0%,P<0.05);而手术组左主干、3支病变比例较高(1.1% vs 7.5%,P<0.05;17.4% vs 62.2%,P<0.05)。住院期间两组复合终点事件无差异(9.6% vs 7.5%,P>0.05)。但外科手术死亡率稍高(3.2% vs7.5%),有一定比例的手术并发症。结论 老年心绞痛病人,接受PCI或CABG治疗是可行的,住院期间两组终点事件无差异。 | 张福春 J Niebauer 郭静萱 G Schuler 毛节明 | 2003 | 中华老年多器官疾病杂志2003，2，3： | 3 |
| 2 | Killing of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia protein显示文摘AIM: To evaluate the synergistic targeting and killing of human hepatocellular carcinoma (HCC) cells lacking p53 by the oncolytic autonomous parvovirus (PV) H-1 and chemotherapeutic agents and its dependence on functional promyelocytic leukemia protein (PML). METHODS: The role of p53 and PML in regulating cy-totoxicity and gene transfer mediated by wild-type (wt) PV H-1 were explored in two pairs of isogenic human hepatoma cell lines with different p53 status. Further-more,H-1 PV infection was combined with cytostatic drug treatment. RESULTS: While the HCC cells with different p53 status studied were all susceptible to H-1 PV-induced apoptosis,the cytotoxicity of H-1 PV was morepronounced in p53-negative than in p53-positive cells. Apoptosis rates in p53-negative cell lines treated by genotoxic drugs were further enhanced by a treatment with H-1 PV. In flow cytometric analyses,H-1 PV infection resulted in a reduction of the mitochondrial transmembrane potential. In addition,H-1 PV cells showed a significant increase in PML expression. Knocking down PML expression resulted in a striking reduction of the level of H-1 PV infected tumor cell death. CONCLUSION: H-1 PV is a suitable agent to circumvent the resistance of p53-negative HCC cells to genotoxic agents,and it enhances the apoptotic process which is dependent on functional PML. Thus,H-1 PV and its oncolytic vector derivatives may be considered as therapeutic options for HCC,particularly for p53-negative tumors. | Maike Sieben Kerstin Herzer Maja Zeidler Vera Heinrichs Barbara Leuchs Martin Schuler Jan J Cornelis Peter R Galle Jean Rommelaere Markus Moehler | 2008 | World Journal of Gastroenterology2008，14，24： | 2 |
| 3 | Molecular characterization of CYP73A9 and CYP82A1 P450 genes involved in plant defense in Pea显示文摘 | Whitbred J M Schuler M A | 2000 | Plant Physiology2000，9，： | 1 |
| 4 | Dyna-CT during minimally invasive off-pump transapical aortic valve implantation 显示文摘 | Kempfert J Falk V Schuler G | 2009 | Ann Thorac Surg2009，88，6： | 1 |
| 5 | Prolaction signals via Stat5 andOctl to the proximal cyclinDl promoter显示文摘 | Brockman J L Schuler L A | 2005 | Mol Cell Endocrino2005，239，12： | 1 |
| 6 | Causes of variable biomass density and its effects on settleability in full-scale biologicalwastewater treatment systems显示文摘 | Schuler A J Jang Hoon | 2007 | Environ Sci Technol2007，41，5： | 1 |
| 7 | Characterization of maize cytochrome P450 monooxygenases induced in response to safeners and bacterial pathogens显示文摘 | PERSANS M W WANG J SCHULER M A | 2001 | Plant Physiol2001，125，2： | 1 |
| 8 | Causes of variable biomass density and its effects on settle ability in full-scale biological wastewater treatment systems 显示文摘 | SCHULER A J JANG H | 2007 | Environ Sci Technol2007，41，5： | 1 |
| 9 | Treatment of idiopathic restless legs syndrome (RLS) with the cabergoline-an open clinical trial 显示文摘 | Robbecke J Schuler P | 2000 | Sleep2000，23，3： | 1 |
| 10 | Dendritic cells as vectors for therapy显示文摘 | Banchereau J Schuler TB Palucka AK | 2001 | Cell2001，106，3： | 1 |
| 11 | GABAB receptor subtypes assemble into functional heteromeric complexes显示文摘 | Kaupmann K Malitschek B Schuler V Heid J Froestl W Beck P | 1998 | Nature1998，396，6712： | 1 |
| 12 | Corporate political activity: a review and research agenda 显示文摘 | HILLMAN A J KEIM G D SCHULER D | 2004 | Journal of Management2004，30，6： | 1 |
| 13 | Natural (^210Pb, ^7Be) and fallout (^137Cs,^239,240pu,^9OSr) radionuclides as geochemical tracers of sedimentation in Greifensee, Switzerland 显示文摘 | Wan G J Santsehi P H Sturm M Farrenkothen K Lueck A Werth W Schuler Ch | 1987 | Chem Geol1987，63，34： | 1 |
| 14 | An Integrative Frameworks of Strategic International Human Resource Management 显示文摘 | Schuler R S Peter J Dowling Helen DeCieril | 1992 | International Journal of Human Resource Management1992，，12： | 1 |
| 15 | Dynamically altering agent behaviors using natural language insU-uctions 显示文摘 | R Bindiganavale W Schuler J Allbeck N Badler A Joshi M Palmer | 2000 | Autonomous Agents (S1573-7454)2000，7，5： | 1 |
| 16 | An integrative framework of strategic international human resource manage- ment显示文摘 | SCHULER R S P J DoMing H DE CIERI | 1993 | Journal of Management1993，19，2： | 1 |
| 17 | Causes of variable biomass density and its effects on settleability in full-scale biological wastewater treatment systems 显示文摘 | Schuler A J Jang Hoon | 2007 | Environ Sci Technol2007，41，5： | 1 |
| 18 | Mammographic feature enhancement by multiscale analysis显示文摘 | Laine A F Schuler S Fan J | 1994 | IEEE Transactions on Medical Image1994，13，4： | 1 |
| 19 | Transcatheter aortic valve implantation: review of the nature, management, and avoidance of procedural complications显示文摘 | Masson JB Kovac J Schuler G | 2009 | JACC Cardiovasc Interv2009，2，9： | 1 |
| 20 | Common active site architecture and binding strategy of four phenylpropanoid P450s from Arabidopsis thaliana as revealed by molecular modeling显示文摘 | Rupasinghe S Baudry J Schuler M A | | 0，，10： | 1 |
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