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| 1 | Hepatitis E virus in patients with acute severe liver injury显示文摘AIM: To examine the incidence of hepatitis E(HepE) in individuals with acute liver injury severe enough to warrant treatment at a transplant unit.METHODS: Hepatitis E virus(HEV) is an emerging pathogen in developed countries causing severe illness, particularly in immunocompromised patients or those with underlying chronic liver disease. HepE infection isoften under diagnosed, as clinicians can be reluctant to test patients who have not travelled to regions traditionally considered hyperendemic for HepE. There are few data regarding the significance of HEV in patients with very severe acute liver injury in developed countries. Eighty patients with acute severe liver injury attending the Scottish Liver Transplant unit were tested for HEV and anti-HEV IgG and IgM. Severe acute liver injury was defined as a sudden deterioration in liver function confirmed by abnormal liver function tests and coagulopathy or presence of hepatic encephalopathy. Eighty percent of these patients were diagnosed with paracetomol overdose. No patients had a history of chronic or decompensated chronic liver disease at time of sampling. IgG positive samples were quantified against the World Health Organization anti-HEV IgG standard. Samples were screened for HEV viral RNA by quantitative reverse transcription polymerase chain reaction.RESULTS: Four cases of hepatitis E were identified. Three of the four cases were only diagnosed on retrospective testing and were initially erroneously ascribed to drug-induced liver injury and decompensated chronic liver disease, with the cause of the decompensation uncertain. One case was caused by HEV genotype 1 in a traveller returning from Asia, the other three were autochthonous and diagnosed on retrospective testing. In two of these cases(where RNA was detected) HEV was found to be genotype 3, the most prevalent genotype in developed countries. Three patients survived, two of whom had been misdiagnosed as having drug induced liver injury. The fourth patient died from sepsis and liver failure precipitated as a result of hepatitis E infection and previously undiagnosed cirrhosis. Histopathology data to date is limited to mainly that seen for endemic HepE. All patients, with the exception of patient 1, demonstrated characteristics of HepE infection, as seen in previously described locally acquired cases.CONCLUSION: In patients with acute severe liver injury, HEV testing should be part of the initial diagnostic investigation algorithm irrespective of suspected initial diagnosis, age or travel history. | Claire Louise Crossan Kenneth J Simpson Darren G Craig Christopher Bellamy Janice Davidson Harry R Dalton Linda Scobie | 2014 | World Journal of Hepatology2014，6，6： | 4 |
| 2 | Human capillary morpho- genesis protein 2 functions as an anthrax toxin receptor 显示文摘 | Scobie HM Rainey OJ Bradley KA | 2003 | Proc Natl Acad Sci U S A2003，100，9： | 1 |
| 3 | Rodent control to fight plague:field assessment of methods based on rat density reduction显示文摘Rodents represent a serious threat to food security and public health.The extent to which rodent control can mitigate the risk from rodent-borne disease depends on both the effectiveness of control in reducing rodent abundance and the impact on disease epidemiology.Focusing on a plague-endemic region of Madagascar,this study compared the effectiveness of 3 methods:live-traps,snap-traps,and rodenticides.Control interventions were implemented inside houses between May and October 2019.Tracking tiles monitored rodent abundance.Rodent fleas,the vector involved in plague transmission,were collected.Rodent populations consisted of Rattus rattus and Mus musculus.In terms of trap success,we found that our live-trap regime was more effective than snap-traps.While all 3 control strategies appeared to reduce in-house rodent activity in the short term,we found no evidence of a longer-term effect,with in-house rodent abundance in treated sites comparable to non-treatment sites by the following month.Endemic flea,Synopsyllus fonquerniei,is a key plague vector usually found on rats living outdoors.Although we found no evidence that its abundance inside houses increased following control,this may have been due to a lack of power caused by significant variation in S.fonquerniei abundance.The presence of S.fonquerniei in houses was more likely when S.fonquerniei abundance on outdoor rats was higher,which in turn correlated with high rat abundance.Our results emphasize that control strategies need to consider this connectivity between in-house rat–flea populations and the outdoor populations,and any potential consequences for plague transmission. | Soanandrasana RAHELINIRINA Kathryn SCOBIE Beza RAMASINDRAZANA Voahangy ANDRIANAIVOARIMANANA Fanohinjanaharinirina RASOAMALALA Lovasoa Nomena RANDRIANTSEHENO Jerry Sylvio RAKOTONIAINA Olivier GORGÉ Xavier LAMBIN Eric VALADE Sandra TELFER Minoarisoa RAJERISON | 2021 | Integrative Zoology2021，16，6： | 1 |
| 4 | Increasing adult hippocampalneurogenesis is sufficient to improve pattern separation显示文摘 | Sahay A Scobie KN Hill AS | 2011 | Na-ture2011，472，： | 1 |
| 5 | Absence of replication-competent human-tropic porcine endogenous retreviruses in the germ line DNA of inbred miniature Swine 显示文摘 | Scobie L Taylor S Wood J | 2004 | J Virel2004，78，： | 1 |
| 6 | Fluid dynamics of cricket ball swing 显示文摘 | SCOBIE JAMES A PICKERING SIMON G ALMOND DARRYL P LOCK GARY D | 2013 | Proceedings of the Institution of Mechanical Engineers Part P: Journal of Sports Engineering and Technology2013，227，3： | 1 |
| 7 | Increasing adult hippocampal neurogenesis is sufficient to Improve pattern separation显示文摘 | Sahay A Scobie KN Hill AS | 2011 | Nature2011，472，7344： | 1 |
| 8 | Torsion of scrotal contents in children 显示文摘 | Mc Combe AM Scobie WG | 1988 | BrJ Urol1988，61，2： | 1 |
| 9 | Falls in English and Welsh hospitals: a national observational study based on retrospective analysis of 12 months of patient safety incident reports显示文摘 | Healey F Scobie S Oliver D | 2008 | Quality and Safety in Health Care2008，17，6： | 1 |
| 10 | Human capillary morpho- genesis protein 2 functions as an anthrax toxin receptor 显示文摘 | Scobie HM Rainey GJ Bradley KA | 2003 | Proc Natl Acad Sci USA2003，，100： | 1 |
| 11 | A Soluble Receptor Decoy Protects Rats against Anthrax Lethal Toxin Challenge显示文摘 | Scobie HM Thomas D Marlett JM | 2005 | The Journal of Infectious Diseases2005，，192： | 1 |
| 12 | Morphine epigenomically regulates behavior through alterations in histone H3 lysine 9 dimethylation in the nucleus accumbens显示文摘 | Sun HS Maze I Dietz DM Scobie KN Kennedy PJ Damez-Werno D | 2012 | J Neurosci2012，32，17： | 1 |
| 13 | Drug experience epigenetically primes Fosb gene inducibility in rat nucleus accumbens显示文摘 | Damez-Werno D Laplant Q Sun HS Scobie KN Dietz DM Walker IM | 2012 | J Neurosci2012，32，10： | 1 |
| 14 | Presentation and incidence of Hirschsprung's disease显示文摘 | Orr JD Scobie WG | 1983 | Br Med J (Clin Res Ed)1983，287，6406： | 1 |
| 15 | Evolution of magnetic resonance imaging changes associated with cerebral hypoxia-ischemia and a relatively selective white matter injury in neonatal rats 显示文摘 | Meng S Qiao M Scobie K | 2006 | Pediatr Res2006，59，41： | 1 |
| 16 | Divalent metal ion coordination by residue T 118 of anthrax toxin receptor 2 is not essential for protective antigen binding显示文摘 | Scobie HM Young JAT | 2006 | PLoS ONE2006，1，99： | 1 |
| 17 | Limited mate availability decrea ses reproductive success of fragmented populations of Lin- naea borealis ,a rare, clonal self-incompatible plant显示文摘 | Scobie A R Wilcoek C C | 2009 | An- nals of Botany2009，103，6： | 1 |
| 18 | Development of a con traceptive vaccine for the marsupial brushtail possum (Tric hosurus vulpecula):Lack of effects in mice and chickens im munised with recombinant possum ZP3 protein and a possum ZP3 antifertility epitope 显示文摘 | Duckworth J A Cui X Scobie S | 2008 | Wildlife Research2008，35，6： | 1 |
| 19 | Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor 显示文摘 | Scobie H Rainey GJ Bradley KA | 2003 | Proc Natl Acad Sci USA2003，100，9： | 1 |
| 20 | Could a publicity campaign for emergency contraception reduce the incidence of unwanted pregnancy and how would we know if it did?显示文摘 | Ziebland S Scobie S | 1995 | Br J Fam Plann1995，21，： | 1 |
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