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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002，，6： | 3 |
| 3 | The magnetic susceptibility of potassium ferrate 显示文摘 | HROSTOWSKI H J SCOTT A B | 1950 | J Chem Physics1950，18，1： | 1 |
| 4 | Myofibroblasts and apoptosis in human hypertrophic scars :the effect of interferon-alpha2b 显示文摘 | Nedelec B Shankowsky H Scott PG | 2001 | Surgery2001，130，5： | 1 |
| 5 | Gold and trace element zonation in pyrite using a laser imaging technique: Implications for the timing of gold in orogenic and Carlin- style sediment- hosted deposits 显示文摘 | R R Large L Danyushevsky C Hollit V Maslennikov S Meffer S Gilbert S Bull R Scott P Emsbo H Thomas B Singh J Foster | 2009 | Economic Geology2009，104，5： | 1 |
| 6 | Calcium anidotrihydroborate:a hydrogen storage material显示文摘 | Diyabalanage H V K Shrestha R P Semelsberger TA Scott B L Bowden M E Davis B L Burrell A K | | 0，，47： | 1 |
| 7 | The International Flow of Human Capital显示文摘 | Grubel H B Scott A D | 1966 | American Economic Review1966，，56： | 1 |
| 8 | Three-dimensionally ordered macroporous Li4Ti5O12:effect of wall structure on electrochemical properties显示文摘 | Erin M S Scott J B Jung H K | 2006 | Chem Mater2006，18，2： | 1 |
| 9 | Hypersonic boundary- layer trip development for Hyper-X 显示文摘 | Scott A B Aaron H A Authur D D | 2001 | Journal of Spacecraft and Rockets2001，38，6： | 1 |
| 10 | Immunity and protection against Brucella abortus 显示文摘 | Golding B Scott DE Scharf 0 Huang LY Zaitseva M Lapham C Eller N Golding H | 2001 | Microbes Infect2001，3，1： | 1 |
| 11 | Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells显示文摘 | Horwitz B H Scott M L Cherry S R | 1997 | Immunity1997，6，6： | 1 |
| 12 | Three dimensionally ordered macroporous Li4Ti5O12 Effect of wall structure on electro- chemical properties 显示文摘 | ERIN M-S SCOTT J B JUNG H K | 2006 | Chem Mater2006，18，： | 1 |
| 13 | Barriers Inhibiting Industry from Partnering with Universities: Evidence from the Advanced Technology Program显示文摘 | HALL B H LINK A N SCOTT J T | 2001 | Journal of Technology Transfer2001，，26： | 1 |
| 14 | The international flow of human capital显示文摘 | Grubel H B Scott A D | 1966 | The American Economic Review1966，，： | 1 |
| 15 | Resin Transfer Molding:A decade of technology advance显示文摘 | CRAIG R H | 1998 | Sampe Journal1998，，6： | 1 |
| 16 | Myofibroblasts and apoptosis in human hypertrophic scar:the effect of interferon-alpha2b显示文摘 | Nedelee B Shankowsky H Scott PG | 2001 | Surgery2001，13，5： | 1 |
| 17 | p53 protein expression in ductal carcinoma in situ (DCIS) of the breast 显示文摘 | Rajan P B Scott D J Perry R H | 1997 | Breast Cancer Rea Treat1997，42，3： | 1 |
| 18 | The growth of word trade:Tariffs,transport costs and income similarities显示文摘 | Scott L B Jeffrey H B | | 0，，01： | 1 |
| 19 | Anevaliation of distinct volu metrcand functional MIU contrbution stoward understanding age and task performance; A study in the basal ganglia显示文摘 | Scott A L Emily M B Najat M H et sl | 2007 | Brain research2007，11，35： | 1 |
| 20 | Understanding Stigma: Dimensions of Deviance and Coping显示文摘 | Elliott G C Zieglcr H L Altman B M Scott D R | 1982 | Deviant Behav- ior1982，，3： | 1 |
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