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| 1 | 血管性认知障碍的诊断标准:国际血管性行为与认知障碍学会的申明显示文摘长期以来,脑血管病(CVD)就被认为是认知损害的一个重要原因,但是有关脑血管病后认知障碍的概念化却有着一段多变的历史。'动脉变硬'或脑的动脉粥样硬化是'老化'的原因,是存在已久的观点,在20世纪60年代受到了来自英格兰纽卡斯尔的神经病理学研究的质疑。这些研究表明,血管性痴呆(vascular dementia,Va D)与超过一定程度的多发性脑梗死有关。 | 徐岩 郭起浩 Sachdev P Kalaria R O'Brien J Skoog I Alladi S Black SE Blacker D Blazer DG Chen C Chui H Ganguli M Jellinger K Jeste DV Pasquier F Paulsen J Prins N Rockwood K Roman G Scheltens P | 2014 | 神经病学与神经康复学杂志2014，11，3： | 19 |
| 2 | Value of postoperative stereotactic radiosurgery and conventional radiotherapy for incompletely resected typical neurocytomas显示文摘 | Rades D Schild SE | 2006 | 中国神经肿瘤杂志2006，4，1： | 11 |
| 3 | Effects of glutamine supplementation on gut barrier,glutathione content and acute phase response in malnourished rats during inflammatory shock显示文摘AIM: To evaluate the effect of glutamine on intestinal mucosa integrity,glutathione stores and acute phase response in protein-depleted rats during an inflammatory shock. METHODS: Plasma acute phase proteins (APP),jejunal APP mRNA levels,liver and jejunal glutathione concentrations were measured before and one,three and seven days after turpentine injection in 4 groups of control,protein-restricted,protein-restricted rats supplemented with glutamine or protein powder. Bacterial translocation in mesenteric lymph nodes and intestinal morphology were also assessed. RESULTS: Protein deprivation and turpentine injection significantly reduced jejunal villus height,and crypt depths. Mucosal glutathione concentration significantly decreased in protein-restricted rats. Before turpentine oil,glutamine supplementation restored villus heights and glutathione concentration (3.24 ± 1.05 vs 1.72 ± 0.46 μmol/g tissue,P < 0.05) in the jejunum,whereas in the liver glutathione remained low. Glutamine markedly increased jejunal α1-acid glycoprotein mRNA level after turpentine oil but did not affect its plasma concentration. Bacterial translocation in protein-restricted rats was not prevented by glutamine or protein powder supplementation. CONCLUSION: Glutamine restored gut glutathione stores and villus heights in malnourished rats but had no preventive effect on bacterial translocation in our model. | Liliana Belmonte Mose Co■ffier Florence Le Pessot Olga Miralles-Barrachina Martine Hiron Antony Leplingard Jean-Franois Lemeland Bernadette Hecketsweiler Maryvonne Daveau Philippe Ducrotté Pierre Déchelotte | 2007 | World Journal of Gastroenterology2007，13，20： | 6 |
| 4 | HBV vaccine efficacy and detection and genotyping of vaccineé asymptomatic breakthrough HBV infection in Egypt显示文摘AIM:To evaluate the impact of mass vaccination against the hepatitis B virus (HBV) in Egypt,and to search for vaccinee asymptomatic breakthrough HBV infection and its genotype.METHODS:Seven hundred serum samples from vaccinated children and adults (aged 2-47 years) were used for quantitative and qualitative detection of HBsAb by ELISA.Three hundred and sixty serum samples representing undetectable or low or high HBsAb were screened for markers of active HBV infection (HBsAg,HBcAb (IgG) and HBeAb by ELISA,plus HBsAg by AxSYM) and HBV-DNA genotyping by nested multiplex PCR and by DNA sequencing.RESULTS:It was found that 65% of children aged 2-4 years,and 20.5% aged 4-13 years,as well as 45% adults were good responders to HBV vaccination mounting protective level HBsAb.Poor responders were 28%,59.5% and 34%,and non-responders were 7%,20% and 21% respectively,in the three studied groups.Markers of asymptomatic HBV infections were HBsAg detected by ELISA in 2.5% vs 11.39% by AxSYM.Other markers were HBcAb (IgG) in 1.38%,HBeAb in 0.83%,and HBV-DNA in 7.8%.All had HBV genotype E infection.CONCLUSION:It is concluded that HBV vaccine is efficient in controlling HBV infection among children and adults.The vaccine breakthrough infection was by HBV genotype E.A booster dose of vaccine is recommended,probably four years after initial vaccination. | Eman AE Abushady Magda MA Gameel John D Klena Salwa F Ahmed Kouka SE Abdel-wahab Sanya M Fahmy | 2011 | World Journal of Hepatology2011，3，6： | 5 |
| 5 | 2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-β1 signaling显示文摘AIM:To investigate whether targeting proteasome might reverse intestinal fibrosis in rats.METHODS:Chronic colitis was induced in rats by repeated administration of increasing dose of2,4,6-trinitrobenzene sulfonic acid(TNBS,15,30,45,60,60,60 mg)by rectal injection for 6 wk(from day0 to day 35),while control rats received the vehicle.TNBS+bortezomib(BTZ)rats received intraperitoneal injections of BTZ twice weekly(from day 37 to day44)at a dose of 25 mg/kg,whereas the control and TNBS groups received the same amount of the vehicle.Histologic scoring of inflammation and fibrosis was performed.Colonic production of transforming growth factor(TGF)-βwas measured by ELISA.Colon fibrosisrelated proteins such as phospho-p38,phosphoSMAD2/3,Akt and peroxisome proliferator activated receptorγ(PPARγ)were studied by western blot.Expression of the tight junction proteins,occludin and claudin-1,were assessed by Western blot.Colon proteasome activities(chymotrypsin-like and trypsinlike activities)were assessed.RESULTS:TNBS-treated rats had a higher colon weight/length ratio compared to control rats(P<0.01).Furthermore,fibrosis and inflammation scores were higher in TNBS-treated rats compared to control rats(P<0.01 for both).Colonic production of TGF-βproduction tended to be higher in TNBS-treated rats(P<0.06).Fibrosis-related proteins such as phospho-p38,phospho-SMAD2/3,and PPARγwere significantly higher in TNBS-treated rats compared to control rats(all P<0.05).TNBS rats had a higher expression of Akt compared to control rats(P<0.01).Tight junction proteins were modified by repeated TNBS challenge:colon occludin expression rose significantly(P<0.01),whereas claudin-1 expression fell(P<0.01).Bortezomib inhibition significantly decreased chymotrypsin-like activity(P<0.05),but had no significant effect on trypsin-like activity(P>0.05).In contrast,bortezomib had no effect on other studied parameters such as fibrosis score,TGF-βsignaling,or tight junction expression(P>0.05 for all).CONCLUSION:Rats with TNBS-induced chronic colitis exhibited colon fibrosis associated with higher TGF-βsignaling.Proteasome inhibition by bortezomib had no effect on fibrosis in our experimental conditions. | Emilien Loeuillard Julien Bertrand Anni Herranen Chloé Melchior Charlène Guérin Mo?se Co?ffier Moutaz Aziz Pierre Déchelotte Guillaume Savoye Rachel Marion-Letellier | 2014 | World Journal of Gastroenterology2014，20，48： | 4 |
| 6 | Radiolabeled cetuximab plus whole-brain irradiation (WBI) for the treatment of brain metastases from non-small cell lung cancer (NSCLC)显示文摘 | Rades D Nadrowitz R Buchmann I Hunold P Noack F Schild SE Meller B. | 2010 | 中国神经肿瘤杂志2010，8，3： | 2 |
| 7 | Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes:a systematic overview显示文摘 | Capes SE Hunt D Malmberg K | 2000 | Lancet2000，355，9206： | 1 |
| 8 | inversions disrupting the factor Ⅷ gene are a common cause of severe hemophilia A 显示文摘 | Lakch D Kazazion HH Antonarakis SE | 1993 | Nat Genet1993，5，： | 1 |
| 9 | Combined aerobic heterotrophic oxidation nitrification and denitrification in a permeable-support biofilm显示文摘 | Timberlake D L Strand SE Williamson KJ | 1988 | Water Research1988，22，12： | 1 |
| 10 | Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostate-specific membrane antigen 显示文摘 | Lupold SE Hicke BJ Lin Y Coffey D | 2002 | Cancer Res2002，62，14： | 1 |
| 11 | Human rabies prevention-United States, 2008: recommendation of the Adviso- ry Committee on Immunization Practices显示文摘 | Manning SE Rupprecht CE Fishbein D | 2008 | MMWR Recomm Rep2008，57，3： | 1 |
| 12 | Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling显示文摘 | Tang DZ Hou W Zhou Q Zhang M Holz J Sheu TJ Li TF Cheng SD Shi Q Harris SE Chen D Wang YJ | 2010 | J Bone Miner Res2010，25，6： | 1 |
| 13 | Nd : YAG inter- stitial laser therapy for pediatric arteriovenous malformations 显示文摘 | Brietzke SE Therberge D ERIC A | 2001 | Operative Techniques in Otolaryngol Head Neck Surg2001，12，4： | 1 |
| 14 | Prevalence of hypertension amongst adult patients attending out patient De partment of Urban Health Training Centre, Department of Community Medicine, Era's Lucknow Medical College and Hospital, Lucknow 显示文摘 | Mahmood SE Prakash D Srivastava JP | 2013 | J Clin Diagn Res2013，7，4： | 1 |
| 15 | The summary of diabetes self-care activities measure: results from 7 studies and a revised scale 显示文摘 | Toobert D J Hampson SE Glasgow RE | 2000 | Diabetes Care2000，23，7： | 1 |
| 16 | Pre-operative risk assessment and risk reduction before surgery 显示文摘 | Poldermans D Hoeks SE Feringa HH | 2008 | J Am Coll Cardiol2008，51，20： | 1 |
| 17 | Mobile robot localization and mapping with uncertainty using scale-invariant visual landmarks显示文摘 | Se S Lowe D Little J | 2002 | International Journal of Robotics Research2002，21，8： | 1 |
| 18 | Comparison of Grid Euler Deconvolution with and without 2D Constraints Using a Realistic 3D Magnetic Basement Model显示文摘 | WILLIAMS SE FAIRHEAD J D FLANAGAN G | 2005 | Geophysics2005，70，1： | 1 |
| 19 | Comparison of trends in prostatecancer mortality in English and Wales and the USA显示文摘 | Oliver SE Gunnell D Donovan JL | 2000 | Lancet2000，355，： | 1 |
| 20 | Measuring health -related quali- ty of life in leukemia : The Functional Assessment of Cancer Therapy - Leukemia( FACT - Leu) questionnaire 显示文摘 | Cella D Jensen SE Webster K | 2012 | Value Heal2012，15，8： | 1 |
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