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| 1 | Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis显示文摘AIM: To determine the clinical impact of portal vein thrombosis in terms of both mortality and hepatic decompensations(variceal hemorrhage, ascites, portosystemic encephalopathy) in adult patients with cirrhosis.METHODS: We identified original articles reported through February 2015 in MEDLINE, Scopus, Science Citation Index, AMED, the Cochrane Library, and relevant examples available in the grey literature. Two independent reviewers screened all citations for inclusion criteria and extracted summary data. Random effects odds ratios were calculated to obtain aggregate estimates of effect size across included studies, with 95%CI.RESULTS: A total of 226 citations were identified and reviewed, and 3 studies with 2436 participants were included in the meta-analysis of summary effect. Patients with portal vein thrombosis had an increased risk of mortality(OR = 1.62, 95%CI: 1.11-2.36, P = 0.01). Portal vein thrombosis was associated with an increased risk of ascites(OR = 2.52, 95%CI: 1.63-3.89, P < 0.001). There was insufficient data available to determine the pooled effect on other markers of decompensation including gastroesophageal variceal bleeding or hepatic encephalopathy. CONCLUSION: Portal vein thrombosis appears to increase mortality and ascites, however, the relatively small number of included studies limits more generalizable conclusions. More trials with a direct comparison group are needed. | Jonathan G Stine Puja M Shah Scott L Cornella Sean R Rudnick Marwan S Ghabril George J Stukenborg Patrick G Northup | 2015 | World Journal of Hepatology2015，7，27： | 42 |
| 2 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 3 | the role of ability Judgements in self - handicapping显示文摘 | Sean M McCrea & Edward R Hirt | 2001 | Personality and Social Psychology Bulletin2001，27，10： | 1 |
| 4 | Different regulation of the fibroblast growth factor(FGF)family by a macroglobulin:evidence for selec tive modulation of FGF-2-induced angiogenesis Blood显示文摘 | Lain R A Sean M W Smitha M | 2001 | Ameriean Congress of Cardiology Adant2001，97，11： | 1 |
| 5 | Stem cells cancer, and cancer stem cells显示文摘 | TANNISHTHA R SEAN J M MICHAEL F C | 2001 | Nature2001，414，6859： | 1 |
| 6 | the role of ability judgements in self-handicapping显示文摘 | | 2001 | Personality and Social Psychology Bulletin2001，27，10： | 1 |
| 7 | Suppression of acute and chronic opioid withdrawal by a selective soluble guanylyl cyclase inhibitor显示文摘 | Michael E S Sean R H Brian M | 2000 | Brain Res2000，859，： | 1 |
| 8 | Asymmetric synthesis of tetracyclic benz-o[a]quinolizidine targets显示文摘 | Steven M Allin Sean N Gaskell Mark R J Elsegood | | 0，，16： | 1 |
| 9 | Effects of Ca(OH)2 treatments (overliming) on the composition and toxicity of bagasse hemicellulose hydrolysates显示文摘 | ALFREDO M MARIA E R SEAN W Y | 2000 | Biotechnology and Bioengineering2000，69，5： | 1 |
| 10 | A synthe- tic route to size-controlled fcc and fct FePt nanoparticles显示文摘 | Luciano E M H Nguyen H L Sean R G | 2005 | Am Chem Soc2005，127，29： | 1 |
| 11 | Using DEA Window Analysis for Performance Evaluation of Iranian Wood Panels Industry 显示文摘 | Hemmasi A Talaeipour M Farzipoor Sean R | 2011 | Agricultural Research2011，6，7： | 1 |
| 12 | High-Mobility Group Box 1 Contributes to Lethality of Endotoxemia in Heme Oxygenase-1-Deficient Mice显示文摘 | Takamiya Rina Hung Chi-Chih Hall Sean R Fukunaga Koichi Nagaishi Takashi Maeno Toshitaka Owen Caroline Macias Alvaro A Fredenburgh Laura E Ishizaka Akitoshi Blumberg Richard S Baron Rebecca M Perrella Mark A | 2009 | American Journal of Respiratory Cell and Molecular Biology2009，，2： | 1 |
| 13 | Coordination at different stages of the product design process 显示文摘 | Bailetti A J Callahan J R Sean M | 1998 | R&D Management1998，28，4： | 1 |
| 14 | The effect of ultraviolet radiation on the vertical distribution and mor- tality of estuarine zooplankton显示文摘 | Christa L S Stephen M B and Sean R A | 2000 | J Plankton Res2000，22，12： | 1 |
| 15 | Magnesium reduces free radicals in an in vivo coronary occlusion-reperfusion model显示文摘 | Lawrence A Garcia Steven C DeJong Sean M Martin Robin S Smith Garry R Buettner Richard E Kerber | 1998 | Journal of the American College of Cardiology1998，，2： | 1 |
| 16 | Nitrogen,Weeds and water as yield-limiting factors in conventional,low-input, and organic tomato systems显示文摘 | M Sean Clark William R Horwath Carol Shennan | 1999 | Agriculture Ecosystems and Environment1999，73，： | 1 |
| 17 | Diagnosis, evaluation and treatment of carcinoma in situ of the urinary bladder: The state of the art 显示文摘 | SEAN R W RODOLFO M ANTONIO L B | 2010 | Crit Rev Oncol Hematol2010，76，2： | 1 |
| 18 | Membrane embedded HIV-1 envelope on the surface of a virus-like particle elicits broader immune responses than soluble envelopes 显示文摘 | Sean P M Kelly R Y Ted M R | 2007 | Virology2007，358，： | 1 |
| 19 | Stem cells,cancer,and cancer stem cells显示文摘 | SEAN J M MICHAEL F C | 2001 | Nature2001，414，： | 1 |
| 20 | The effect of ultraviolet radiation on the vertical distribution and mortality of estuarine zooplankton显示文摘 | Christa L S Stephen M B Sean R A | 2000 | J Plankton Res2000，22，12： | 1 |
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