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| 1 | Prospective randomized controlled trial evaluating cap-assisted colonoscopy vs standard colonoscopy显示文摘AIM: To study the significance of cap-fitted colonoscopy in improving cecal intubation time and polyp detection rate. METHODS: This study was a prospective randomized controlled trial conducted from March 2008 to February 2009 in a tertiary referral hospital at Sydney. The primary end point was cecal intubation time and the secondary endpoint was polyp detection rate. Consecutive cases of total colonoscopy over a 1-year period were recruited. Randomization into either standard colonoscopy (SC) or cap-assisted colonoscopy (CAC) was performed after consent was obtained. For cases randomized to CAC, one of the three sizes of cap was used: D-201-15004 (with a diameter of 15.3 mm), D-201-14304 (14.6 mm) and D-201-12704 (13.0 mm). All of these caps were produced by Olympus Medical Systems, Japan. Independent predictors for faster cecal time and better polyp detection rate were also determined from this study. RESULTS: There were 200 cases in each group. There was no signif icant difference in terms of demographic characteristics between the two groups. CAC, when compared to the SC group, had no signif icant difference in terms of cecal intubation rate (96.0% vs 97.0%, P = 0.40) and time (9.94 ± 7.05 min vs 10.34 ± 6.82 min, P = 0.21), or polyp detection rate (32.8% vs 31.3%, P = 0.75). On the subgroup analysis, there was no significant difference in terms of cecal intubation time by trainees (88.1% vs 84.8%, P = 0.40), ileal intubation rate (82.5% vs 79.0%, P = 0.38) or total colonoscopy time (23.24 ± 13.95 min vs 22.56 ± 9.94 min, P = 0.88). On multivariate analysis, the independent determinants of faster cecal time were consultant-performed procedures (P < 0.001), male patients (P < 0.001), non-usage of hyoscine (P < 0.001) and better bowel preparation (P = 0.01). The determinants of better polyp detection rate were older age (P < 0.001), no history of previous abdominal surgery (P = 0.04), patients not having esophagogastroduodenoscopy in the same setting (P = 0.003), trainee-performed procedures (P = 0.01), usage of hyoscine (P = 0.01) and procedures performed for polyp follow-up (P = 0.01). The limitations of the study were that it was a single-center experience, no blinding was possible, and there were a large number of endoscopists. CONCLUSION: CAC did not signif icantly different from SC in term of cecal intubation time and polyp detection rate. | Hoi-Poh Tee Crispin Corte Hamdan Al-Ghamdi Emilia Prakoso John Darke Raman Chettiar Wassim Rahman Scott Davison Sean P Griffin Warwick S Selby Arthur J Kaffes | 2010 | World Journal of Gastroenterology2010，16，31： | 10 |
| 2 | Bisphosphonates in the treatment of Charcot neuroarthropathy:a double-blind randomized controlled trial显示文摘 | Jude EB Selby PL Burgess J | 2001 | Diabetologia2001，44，11： | 1 |
| 3 | Insecticidal Anthranilamide: a New Class of Potent Ryanodine Receptor Activators显示文摘 | LAHM G P SELBY T P FREUDENBERGER J H | 2005 | Bioorganic & Medicinal Chemistry Letters2005，，15： | 1 |
| 4 | Detection of coloreetal cancer cells in peripheral blood by reverse transcriptase polymerase chain reaction for cytokeratin 20 显示文摘 | Wyld D K Selby P Perren T J | 1998 | Int J Cancer1998，79，3： | 1 |
| 5 | Transfection of differentiated human hepatoms cell line (Huh7) with in vitro - transcribed hepatitis C virus of (HCV)RAN and establishment of a long tern culture persistently in fected with HCV 显示文摘 | Yoo B J Selby M J Choe J | 1995 | Virol1995，69，1： | 1 |
| 6 | Precursors of essential hy- pertension: pulmonary function, heart rate, uric acid, serum choles- terol cholesterol, and other serum chemistries 显示文摘 | Selby J'V Friedman GD Ouesenberry CP | 1990 | Am J Epidemiol1990，131，6： | 1 |
| 7 | Very low quality of life afteracute stroke : data from the Efficacy of Nitric Oxide in Stroke trial显示文摘 | Sprigg N Selby J Fox L | 2013 | Stroke2013，44，12： | 1 |
| 8 | Detection of melanoma cells in peripheral blood by means of reverse transcriptase and polymerase chain reaction 显示文摘 | Smith B Selby P Southgate J | 1991 | Lancet1991，338，8777： | 1 |
| 9 | Detection of melanoma ceils in perihperal blood by means of reverse transcriptase and polymerase chain reaction显示文摘 | Smith B Selby P Southgate J | 1991 | Lancet1991，338，8777： | 1 |
| 10 | Isolation and nucleotide sequence of a c DNA encoding the precursor of mouse nerve growth factor显示文摘 | Scott J Selby M Urdea M | 1983 | Nature1983，302，5908： | 1 |
| 11 | Body burdens of lead in hypertensive nephropathy 显示文摘 | Osterloh J D Selby J V Bernard B P | 1989 | Arch Environ Health1989，44，5： | 1 |
| 12 | Reconstruing place image:A case study of its role in destination market research显示文摘 | Martin Selby Nigel J Morgan | | 0，，04： | 1 |
| 13 | Insecticidal anthranilic diamides:a new class of potent ryanodine receptor activators显示文摘 | LAHM G P SELBY T P FREUDENBERGER J H | 2005 | Bioorganic & Medicinal Chemistry Letters2005，15，： | 1 |
| 14 | Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor显示文摘 | Scott J Selby M Urdea M Quiroga M Bell GI Rutter WJ | 1983 | Nature1983，302，5908： | 1 |
| 15 | The incidence of colorectal cancer following a negative screening sigmoidoscopy: implications for screening interval 显示文摘 | DORIA-ROSE V P LEVIN T R SELBY J V | 2004 | Gastroenterology2004，127，3： | 1 |
| 16 | Hemodialysis- induced cardiac injury: determinants and associated out- comes显示文摘 | Burton JO Jefferies H J Selby NM | 2009 | Clin J Am Soc Nephrol2009，4，5： | 1 |
| 17 | Simulation of dynamic compaction of loose granular soils 显示文摘 | Pan J L Selby A R | 2002 | Advances in Engineering Software2002，33，710： | 1 |
| 18 | Self-efficacy and the stages of exercise behavior change 显示文摘 | Marcus B H Selby V C Niaura R S Rossi J S | 1992 | Research Quarterly for Exercise and Sport1992，63，： | 1 |
| 19 | Investigation of Several Passive and Active Methods for Turbulent Flow Separation Control显示文摘 | Lin J C Howard F G Bushnell D M Selby G V | 1990 | AIAA Journal1990，28，6： | 1 |
| 20 | Cool dialysate reduces asymptomatic intradialytie hypotension and increases baroreflex variability显示文摘 | Chesterton L J Selby N M Burton J O | 2009 | Hemodial Int2009，13，2： | 1 |
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