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| 1 | Single-nucleotide polymorphisms in HORMAD1 may be a risk factor for azoospermia caused by meiotic arrest in Japanese patients显示文摘基因机制作为一些男不孕的一个原因被含有,还糟糕被理解。成熟分裂为复制对细菌房间和必需品唯一。synaptonemal 建筑群是为染色体配对,分离和再结合的一个批评部件。因为猛烈雄的老鼠是不肥沃的, Hormad1 为哺乳动物的 gametogenesis 是必要的。在早 pachytene 阶段和 synaptonemal 建筑群的 Hormad1 缺乏的睾丸展览 meiotic 拘捕不能被设想。为了分析人的 HORMAD1 基因缺点与人的精子缺乏被联系的假设,由 meiotic 拘捕引起了, mutational 分析被诊断,精子缺乏源于 meiotic 的 30 个日本人的直接顺序分析在所有编码区域执行拘捕。由顺序分析,三个多型性地点,单个核苷酸多型性 1 (c。163A > G ) , SNP2 (c。501T > G ) 并且 SNP3 (c。918C > T ) ,在 exons 被发现 3, 8 和 10。有精子缺乏和 80 个正常的证明怀孕的、肥沃的人的 30 个病人为 HORMAD1 多型性被分析。SNP1 和 SNP2 与人的精子缺乏由完全的早 meiotic 拘捕引起了被联系(P< 0.05 ) 。我们建议 HORMAD1 让必要 meiotic 在人的精子发生工作。 | Toshinobu Miyamoto Aldra Tsujimura Yasushi Miyagawa Eitetsu Koh Mikio Namiki Michiharu Horikawa Yasuaki Saijo Kazuo Sengoku | 2012 | Asian Journal of Andrology2012，14，4： | 3 |
| 2 | SPATA17的单核苷酸多态性可能是日本减速分裂阻滞患者的遗传危险因素显示文摘遗传机制已经成为一些男性患者不育的一个病因。近年来,通过人类睾丸组织的基因芯片分析鉴定了10个与人类精子发生相关的新基因。其中一个是精子发生相关17基因(SPATA17)。为了研究是否SPATA17基因缺陷与减数分裂导致的无精症有关,我们进行了突变分析,将18个日本减数分裂导致的无精症患者的SPATA17编码区域进行了测序,以及统计分析,其中包括18个减数分裂阻滞患者,20个唯支持细胞综合征(SCOS)患者和96个健康对照男性。没有SPATA17发生突变。但是,减数分裂阻滞患者组检测到了3个单核苷酸多态性(cSNPs:SNPI—SNP3)。减数分裂阻滞患者与其他患者的SNP1和SNP2基因型与等位基因频率无明显不同。但是,SNP3的等位基因频率在减数分裂阻滞患者组中明显升高(P〈0.05)。这项研究表明,sPATA17在人类精子发生,尤其是减数分裂中可能起关键性作用。 | Toshinobu Miyamoto Akira Tsujimura Yasushi Miyagawa Eitetsu Koh Naoko Sakugawa Hiroe Miyakawa Hisashi Sato Mikio Namiki Akihiko Okuyama Kazuo Sengoku | 2009 | Asian Journal of Andrology2009，11，5： | 2 |
| 3 | A case of cardiac myxoma presenting with multiple cerebellar hemorrhages and elevation of interleukin-6 in the cerebrospinal fluid显示文摘 | Yaguchi H Murakami Y Sengoku R | 2004 | Rinsho Shinkeigaku2004，44，10： | 1 |
| 4 | Requirement of nitric oxide for murine oocyte maturation, embryo development, and trophoblast outgrowth in vitro 显示文摘 | SENGOKU K TAKUMA N HORIKAWA M | 2001 | Mol Reprod Dev2001，58，3： | 1 |
| 5 | Mouse/human sequence divergence in a region with a paternal-specific methylation imprint at the human H19 locus显示文摘 | Minno Y Sengoku K Nakao M | 1996 | Hum Mol Genet1996，5，8： | 1 |
| 6 | Analysis of communication traffic characteristics of a cellular system with ad hoc networking显示文摘 | TANAKA A NAKANO K SENGOKU M | 2003 | Electronics and Communications in Japan2003，86，11： | 1 |
| 7 | Requirement of nitric oxide for murine oocyte maturation, embryo development, and trophoblast outgrowth in vitro显示文摘 | Sengoku K Takuma N Horikawa M | 2001 | Mol Reprod Dev2001，58，3： | 1 |
| 8 | Flux decline behaviors in dead-end microfiltration of activated sludge and its supernatant显示文摘 | Iritani E Katajiri N Sengoku T | 2007 | J Membrane Sci2007，300，12： | 1 |
| 9 | Nuclear dynamics of parthe- nogenesis of human oocytes : Effect of oocyte aging in vitro 显示文摘 | Sengoku K Takuma N Miyamato T | 2004 | Gyne- col Obstet Invest2004，58，3： | 1 |
| 10 | Nuclear dynamics of parthenogenesis of human oocytes: Effect of oocyte aging in vitro显示文摘 | Sengoku K Takuma N Miyamato T | 2004 | Gynecol Obstet Invest2004，58，3： | 1 |
| 11 | The soluble and membrane - anchored forms of heparin - binding epidermal growth factor - like growth factor appear to play opposing roles in the survival and apoptosis of human luteinized granulosa cells显示文摘 | Bochen Pan Kazuo Sengoku Katsutoshi Goishi | 2002 | Molecular Human Reproduction2002，8，8： | 1 |
| 12 | Polynuclear fertilization in various stimulation protocols in in vitro fertilization 显示文摘 | Sengoku K Ishikawa M Tamate K | 1994 | Int J Fertil Menopausal Stud1994，39，1： | 1 |
| 13 | Claudin-7 expressed on lateral membrane of rat epididymal epithelium does not form aberrant tight junction strands显示文摘 | Inai T Sengoku A Hirose E | 2007 | Anat Rec (Hoboken)2007，290，： | 1 |
| 14 | Requirement of nitric oxide for murine oocyte maturation,embryo development,and trophoblast outgrowth in vitro显示文摘 | Sengoku K Takuma N Horikawa M | 2001 | Mol Reprod Dev2001，58，3： | 1 |
| 15 | Effect of imposing changes in kick frequency on kinematics during undulatory underwater swimming at maximal effort in male swimmers 显示文摘 | Shimojo H Sengoku Y Miyoshi T | 2014 | Human movement science2014，，38： | 1 |
| 16 | Synthetic Aperture FMCW Radar Applied to the Detection of Objects Buried in Snowpack 显示文摘 | Yamaguchi Y Mitsumoto M Sengoku M | 1994 | IEEE Trans Geoscience and Remote Sensing1994，32，1： | 1 |
| 17 | TEM7 (PLXDC1) in neovascular endothelial cells of fibro-vascular membranes from patients with proliferative diabeticretinopathy显示文摘 | Yam^ji Y Yoshida S Ishikawa K Sengoku A Sato K Yoshida A | 2008 | Invest Ophthalmol Vis Sci2008，49，7： | 1 |
| 18 | Nuclear dynamics of parthenogenesis of human oocytes: Efect of oocyte aging in vitro显示文摘 | Sengoku K Takuma N Miyamato T el a l | 2004 | Gynecol Obstet Invest2004，58，3： | 1 |
| 19 | Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA dam-age sites in DNA repair during G1 phase显示文摘 | Niida H Katsuno Y Sengoku M | 2010 | Genes Dev2010，24，4： | 1 |
| 20 | Isolation and expression analysis of the testis-specific gene, STRA8, stimulated by retinoic acid gene 8 显示文摘 | MIYAMOTO T SENGOKU K TAKUMA N | 2002 | Journal of Assisted Reproduction andGenetics2002，19，11： | 1 |
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