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| 1 | Alterations in metastatic properties of hepatocellular carcinoma cell following H-ras oncogene transfection显示文摘AIM To demonstrate the relationship betweenH-ras oncogene and hepatocellular carcinoma(HCC) metastasis.METHODS Activated H-ras oncogene wastransfected into SMMC 7721, a cell line derivedfrom human HCC, by calcium phosphatetransfection method. Some metastasis-relatedparameters were detected in vitro, includingadhesion assay, migration assay, expression ofcollagenase ⅣV (c ⅣV ase) and epidermal growthfactor receptor (EGFR).RESULTS The abilities of H-ras-transfected cellclones in adhesion to laminin (LN) or fibronectin(FN), migration, c Ⅳ ase secretion increasedmarkedly, and the expression of EGFR elevatedmoderately. More importantly, these alterationswere consistent positively with the expressionof p21, the protein product of H-ras oncogene.CONCLUSION H-ras oncogene could inducethe metastatic phenotype of HCC cell in vitro toraise its metastatic potential. | Qing Wang~1 Zhi Ying Lin~2 Xiao Li Feng~3 ~1Department of Microbiology,Medical Center of Fudan University.the former Shanghai Medical University,Shanghai 200032,China ~2Liver Cancer Institute,Zhongshan Hospital,Shanghai 200032,China ~3Shanghai Institute of Biochemistry,Academy Sinica,Shanghai 200031,ChinaQing Wang earned master degree from Shanghai Medical University in 1996,now a senior lecturer of microbiology,specialized in the role of oncogcncs on tumor metastasis,having 8 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 48 |
| 2 | Development and implementation of a new flowsheet for the flotation of a low grade nickel ore 显示文摘 | Senior G D Thomas S A | 2005 | International Journal of Mineral Processing2005，78，1： | 1 |
| 3 | Experimental Detec- tion of the Edge-Diffracted Cone显示文摘 | Senior T B A Uslenghi P L E | 1972 | Proceedings of the IEEE1972，60，11： | 1 |
| 4 | Fixed-Bed Studies of the Interactions Between Mercury and Coal Combustion Fly Ash 显示文摘 | Dunham G E Dewall R A Senior C L | 2003 | Fuel Processing Technology2003，82，2： | 1 |
| 5 | Emissions of mercury, trace elements, and fine particles from stationary combustion sources显示文摘 | SENIOR C L HELBLE J J SAROFIM A F | 2000 | Fuel Process Technol2000，6566，： | 1 |
| 6 | Gas phase transformation of mercury in coal--fired power plants 显示文摘 | Senior C L Sarofim A F Zong T | 2000 | Fuel Processing Technology2000，，2： | 1 |
| 7 | How Far is Far 显示文摘 | E F Knott T B A Senior | 1974 | IEEE Transactions on Antennas And Propagation1974，，： | 1 |
| 8 | Botox and the management of pectoral spasm after subpectoral implant insertion 显示文摘 | Senior Michael A | 2000 | Plast Reconstr Surg2000，106，1： | 1 |
| 9 | Host Susceptibility to endogenous viruses:defective,glycoprotein-expressing proviruses interfere with infections显示文摘 | Robinson H L Astrin S M Senior A M | 1981 | J Virol1981，40，3： | 1 |
| 10 | The role of neurohormonal antagonists in hibernating myocardium显示文摘 | LAHIRI A SENIOR R KHATTAR R | 1999 | J Cardiovasc Phamacol1999，33，3： | 1 |
| 11 | The regulation of poly-beta-hydroxybutyrate metabolism in Azotobacter beijerinckii 显示文摘 | Senior P J Dawes E A | 1973 | Biochem1973，134，： | 1 |
| 12 | Scattering by a narrow gap显示文摘 | Senior T B A Natzke J R | 1989 | IEEE Trans Antenna Propagate1989，37，3： | 1 |
| 13 | Fixed-bed studies of the interactions between mercury and coal combustion fly ash显示文摘 | DUNHAM G E DEWALL R A SENIOR C L | 2003 | Fuel Processing Technology2003，82，： | 1 |
| 14 | Intravenous myocardial contrast echocardiography predicts recovery of dysynergic myocardium early after acute myocardial infarction显示文摘 | Swinburn JM Lahiri A Senior R | 2001 | J Am Coll Cardiol2001，38，1： | 1 |
| 15 | Intravenous myocardial contrast echocar-ography predicts recovery of dysynergic myocardium early after acute myocardial infarction 显示文摘 | Swinburn JM Lahiri A Senior R | 2001 | J Am Coll Cardiol2001，38，1： | 1 |
| 16 | Distri- bution of trace elements in selected pulverized coals as a function of particle size and density 显示文摘 | Senior C L Zeng T Che J Ames M R Sarofim A F Olmez I | 2000 | Fuel Process Technology2000，63，23： | 1 |
| 17 | Synthesis of tough nanoporous metals by controlled electrolytic dealloying 显示文摘 | SENIOR N A NEWMAN R C | 2006 | Nanotechnology2006，17，： | 1 |
| 18 | Simplified simulation system for construction projects显示文摘 | Senior B A Halpin D W | 1998 | Journal of Construction Engineering and Management ASCE1998，124，1： | 1 |
| 19 | Emissions of Mercury, Trace Elements, and Fine Particles From Stationary Com- bustion Sources 显示文摘 | Senior C L Helble J J Sarofim A F | 2000 | Fuel Processing Technology2000，65，： | 1 |
| 20 | What is the normal range for N-terminal pro-brain natriuretic peptide? How well does this normal range screen for cardiovascular disease显示文摘 | Galasko GI Lahiri A Barnes SC Collinson P Senior R | | 0，，： | 1 |
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