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| 1 | Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease显示文摘AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty liver disease(NAFLD) models.METHODS: Male C57BL/6J mice were classified according to control or high fat diet(HFD) with or without PPAR-δ agonist(GW) over period of 12 wk [control, HFD, HFD + lipopolysaccharide(LPS), HFD + LPS + GW group]. Hep G2 cells were exposed to palmitic acid(PA) and/or LPS in the absence or presence of GW.RESULTS: HFD caused glucose intolerance and hepatic steatosis. In mice fed an HFD with LPS, caspase-1 and interleukin(IL)-1β in the liver were significantly increased. Treatment with GW ameliorated the steatosis and inhibited overexpression of pro-inflammatory cytokines. In Hep G2 cells, PA and LPS treatment markedly increased m RNA of several nucleotide-binding andoligomerization domain-like receptor family members(NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1β. PA and LPS also exaggerated reactive oxygen species production. All of the above effects of PA and LPS were reduced by GW. GW also enhanced the phosphorylation of AMPK-α.CONCLUSION: PPAR-δ agonist reduces fatty acidinduced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-δ agonist may have therapeutic implication for NAFLD. | Hyun Jung Lee Jong Eun Yeon Eun Jung Ko Eileen L Yoon Sang Jun Suh Keunhee Kang Hae Rim Kim Seoung Hee Kang Yang Jae Yoo Jihye Je Beom Jae Lee Ji Hoon Kim Yeon Seok Seo Hyung Joon Yim Kwan Soo Byun | 2015 | World Journal of Gastroenterology2015，21，45： | 9 |
| 2 | Ampullary neuroendocrine tumor diagnosed by endoscopic papillectomy in previously confirmed ampullary adenoma显示文摘Ampullary adenoma is a common indication for endoscopic papillectomy. Ampullary neuroendocrine tumor(NET) is a rare disease for which complete surgical resection is the treatment of choice. However, because of the morbidity and mortality associated with surgical resection, endoscopic papillectomy is increasingly used in selected cases of low grade, with no metastasis and no invasion of the pancreatic or bile duct. Also, confirmed and complete endoscopic resection of ampullary NET accompanied by adenoma has not been reported to date. We report herein a rare case of an ampullary NET accompanied with adenoma, which was successfully and completely resected via endoscopic papillectomy. Prior to papillectomy, this case was diagnosed as an ampullary adenoma. | Seoung Ho Lee Tae Hoon Lee Si-Hyong Jang Chi Young Choi Won Myung Lee Ji Hey Min Hyun Deuk Cho Sang-Heum Park | 2016 | World Journal of Gastroenterology2016，22，13： | 6 |
| 3 | Epidermal growth factor upregulates Skp2/Cks1 and p27^(kip1) in human extrahepatic cholangiocarcinoma cells显示文摘AIM:To evaluate the expression status of S-phase kinase-associated protein 2(Skp2)/cyclin-dependent kinases regulatory subunit 1(Cks1)and p27kip1,and assess the prognostic significance of Skp2/Cks1 expression with p27kip1in patients with extrahepatic cholangiocarcinoma.METHODS:Seventy-six patients who underwent curative resection for histologically confirmed extrahepatic cholangiocarcinoma at our institution from December1994 to March 2008 were enrolled.Immunohistochemical staining for Skp2,Cks1,p27kip1,and Ki67,along with other relevant molecular biologic experiments,were performed.RESULTS:By Cox regression analyses,advanced age(>65 years),advanced AJCC tumor stage,poorly differentiated histology,and higher immunostaining intensity of Skp2 were identified as independent prognostic factors in patients with extrahepatic cholangiocarcinoma.Exogenous epidermal growth factor(EGF,especially 0.1-10 ng/mL)significantly increased the proliferation indices by MTT assay and the mRNA levels of Skp2/Cks1 and p27kip1in SNU-1196,SNU-1079,and SNU-245 cells.The protein levels of Skp2/Cks1(from nuclear lysates)and p27kip1(from cytosolic lysate)were also significantly increased in these cells.There were significant reductions in the protein levels of Skp2/Cks1and p27kip1(from nuclear lysate)after the treatment of LY294002.By chromatin immunoprecipitation assay,we found that E2F1 transcription factor directly binds to the promoter site of Skp2.CONCLUSION:Higher immunostaining intensity of Skp2/Cks1 was an independent prognostic factor for patients with extrahepatic cholangiocarcinoma.EGF upregulates the mRNA and protein levels of Skp2/Cks1and p27kip1via the PI3K/Akt pathway and direct binding of E2F1 transcription factor with the Skp2 promoter. | Ja-yeon Kim Hong Joo Kim Jung Ho Park Dong Il Park Yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik Kim Dong Hoon Kim Seoung Wan Chae Jin Hee Sohn | 2014 | World Journal of Gastroenterology2014，20，3： | 4 |
| 4 | FEATURE NETWORK-DRIVEN QUADRANT MAPPING FOR SUMMARIZING CUSTOMER REVIEWS显示文摘与电子商务的快速的生长,顾客们逐渐地写他们购买的产品的联机评论。这些顾客评论是影响产品或服务的选择的信息的最珍贵的来源之一。总结这些顾客评论正在成为研究的一个有趣的区域,鼓舞研究人员开发为用户的更多压缩的、简明摘要。然而,没有特征关系,大多数在摘要的当前的努力基于一般产品特征。作为结果,这些摘要也从顾客忽略反馈或做反映在顾客评论表示的意见的一个差的工作。补救这个摘要缺点,我们建议一个特征印射的网络驱动的象限从顾客评论捕获并且合并意见。我们的焦点在一个特征网络的建设,它基于同现,预告危险的类似,和一个象限显示显示出特征组的意见极性。而且,建议途径涉及聚类类似的产品展示,并且这样,它基于抽象和抽取与标准文章摘要不同。总结结果罐头帮助顾客更好关于一个产品理解全面意见。 | Su Gon Cho Seoung Bum Kim | 2017 | Journal of Systems Science and Systems Engineering2017，26，5： | 2 |
| 5 | Hepatitis B virus X mutations occurring naturally associated with clinical severity of liver disease among Korean patients with chronic genotype C infection显示文摘 | Hyun‐JuKim Joo‐HeePark YoungmeeJee Seoung‐AeLee HongKim Byung‐CheolSong SoohyunYang MyungheeLee Jung‐HwanYoon Yoon JunKim Hyo‐SukLee Eung‐SooHwang Yoon‐HohKook Bum‐JoonKim | 2008 | J. Med. Virol2008，，8： | 2 |
| 6 | Gender disparity in distribution of the major hydrophilic region variants of hepatitis B virus genotype C according to hepatitis B e antigen serostatus显示文摘 | Seoung‐AeLee Yoo‐KyungCho Keun‐HwaLee Eung‐SooHwang Yoon‐HohKook Bum‐JoonKim | 2011 | J Med Virol2011，，3： | 2 |
| 7 | Naturally occurring hepatitis B virus X deletions and insertions among Korean chronic patients显示文摘 | Seoung‐AeLee Ho‐SukMun HongKim Hyung‐KiLee Buyng‐JunKim Eung‐SooHwang Yoon‐HohKook Bum‐JoonKim | 2010 | J. Med. Virol2010，，1： | 2 |
| 8 | Naturally occurring hepatitis B virus X deletions and insertions among Korean chronic patients显示文摘 | Seoung‐AeLee Ho‐SukMun HongKim Hyung‐KiLee Buyng‐JunKim Eung‐SooHwang Yoon‐HohKook Bum‐JoonKim | 2010 | J Med Virol2010，，1： | 1 |
| 9 | Hepatitis B virus X mutations occurring naturally associated with clinical severity of liver disease among Korean patients with chronic genotype C infection显示文摘 | Hyun‐JuKim Joo‐HeePark YoungmeeJee Seoung‐AeLee HongKim Byung‐CheolSong SoohyunYang MyungheeLee Jung‐HwanYoon Yoon JunKim Hyo‐SukLee Eung‐SooHwang Yoon‐HohKook Bum‐JoonKim | 2008 | J Med Virol2008，，8： | 1 |
| 10 | Mechanisms of edema formation after intracerebral hemorrhage: effects of thrombin on cerebral blood flow, blood-brain barrier permeability, and cell survival in a rat model显示文摘 | Kevin R Lee Nobuyuki Kawai Seoung Kim | | 0，，： | 1 |
| 11 | Genetic algo- rithm-based feature selection in high-resolution NMR spectra 显示文摘 | Cho Hyun Woo Kim Seoung Bum Jeong | 2008 | Expert Systems with Applications2008，35，3： | 1 |
| 12 | Mechanisms of edema formation after intracerebral hemorrhage:effects of thrombin on cerebral blood flow,blood-brain barrier permeability and cell survival in a rat model显示文摘 | Kevin R Nobuguki K Seoung K | | 0，，： | 1 |
| 13 | 显示文摘 | Zeng Xiaoqing Seoung J I Sang H J | 2006 | Journal of Luminescence2006，，121： | 1 |
| 14 | Overexpressions of cyclin B1,cdc2,p16 and p53 in human breast cancer:the clinicopathologic correlations and prognostic implications显示文摘 | SEOUNG WC SOHN JH KIM DH | 2011 | Yonsei Med J2011，52，3： | 1 |
| 15 | Characteristics of electrical responsive alginate/poly (diallyldimethylammonium chloride) IPN hydrogel in HCI solutions显示文摘 | SEON JEONG KIM SEOUNG GIL YOON SANG MIN LEE | 2003 | Sensors and Actuators B2003，，96： | 1 |
| 16 | Cou- marin Glycosides from the Roots of Angelica dahurica 显示文摘 | Seoung Hart Kim Sam Sik Kang Chang Min Kim | 1992 | Arch Pharm Res1992，15，1： | 1 |
| 17 | Overexpressions o显示文摘 | Seoung WC Sohn JH Kim DH | 2011 | Yonsei Med J2011，52，3： | 1 |
| 18 | FRP: A frontier-based tree-pruning algorithm 显示文摘 | Xiaoming Huo Seoung Bum Kim Kwok-Leung Tsui Shuchun Wang | 2006 | INFORMS Journal on Computing2006，18，4： | 1 |
| 19 | Biomechanical Evaluation of an Interspinous Stabilizing Device, Locker 显示文摘 | Chan SS Seoung WP Lee SH | 2008 | SPINE2008，33，22： | 1 |
| 20 | Electrical sensitive behavior of poly(vinyl alcohol)/poly(diallyldimethylammonium chloride)IPN hydrogel显示文摘 | Seon Jeong Kim Seoung Gil Yoon Young Moo Lee | 2003 | Sensors and Actuators B:Chemical2003，88，3： | 1 |
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